Compare Keflex vs. Cleocin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Keflex
(Cephalexin)

Cleocin T
(Clindamycin Phosphate)

Kills bacteria. Keflex (Cephalexin) is good for treating many bacterial infections and is available as generic. However, if you are on medications to thin your blood, you can be more likely to bleed.Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.0662739322533135Keflex
Reviews for Keflex (Cephalexin)
63%
of people say Keflex (Cephalexin) is worth it
48%
say it works well
14%
say it's a big hassle
Reviews for Cleocin T (Clindamycin Phosphate)
57%
6% vs. Keflex (Cephalexin)
43%
5% vs. Keflex (Cephalexin)
20%
6% vs. Keflex (Cephalexin)
Side effects
KeflexCleocin

The Keflex FDA package insert doesn’t have numbers about how common side effects are.

More about Keflex side effects »
  • Vaginal moniliasis 6%
More Cleocin side effects »
How it works
KeflexCleocin
Keflex (Cephalexin) is an antibiotic. It kills bacteria by preventing them from making their own protective covering.Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
KeflexCleocin
Antibiotic
Cephalosporin
Prescription only
Acne agent
Antibiotic
Prescription only
Available as
KeflexCleocin
  • Pill
  • Powder for oral suspension
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
Used for (click to learn more)
KeflexCleocin
Risk factors for serious side effects
KeflexCleocin
    Detailed Keflex (Cephalexin) risks & warnings »
      • History of liver disease
        Detailed Cleocin T (Clindamycin Phosphate) risks & warnings »
        Pregnancy category
        KeflexCleocin
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        • Can be taken with or without food.
        • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
        • Can be taken with or without food.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.
        • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
        • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        KeflexCleocin
        • Available in different forms: tablet, capsule, and suspension.
        • Available in generic.
        • Used to treat many types of bacterial infections.
        • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
        • Can be taken with or without food.
        • Topical form treats acne.
        • Available in different oral forms: tablet, capsule, and suspension.
        • Available in forms to treat skin infections and vaginal infections.
        • Available in generic.
        • Used to treat many types of bacterial infections.
        • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
        • Can be taken with or without food.
        Downsides and risks
        KeflexCleocin
        • If you're on blood thinners (anticoagulants), talk to your doctor, it may make you more likely to bleed.
        • If you have to take any live vaccines, talk to your doctor. You may have to postpone it.
        • Can cause diarrhea.
        • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
        • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
        • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
        • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
        • If you're taking the topical form, it can cause sensitivity and irritation.
        Tips from our pharmacists for people taking the medication
        KeflexCleocin
        • Take this medication exactly as your doctor tells you to.
        • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
        • Space out vitamins by a couple hours if you're taking this medication.
        • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
        • Take this medication exactly how your doctor tells you to.
        • Store the suspension at room temperature.
        • If you're using the topical form, it can take a few weeks to see the full effect.
        • Keep the topical form out of your eyes, nose and mouth.
        • If you're using the topical form, Don't put makeup or bandages over it.
        • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
        Learn more
        More about KeflexSide effectsReviews & ratingsAlternativesFDA package insert
        More about CleocinSide effectsReviews & ratingsAlternativesFDA package insert