Compare Keflex vs. Levaquin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Keflex
(cephalexin)

Levaquin
(levofloxacin)

Treats bacterial infections. Keflex (cephalexin) is good for treating many bacterial infections, and is available as a generic.Kills bacteria. Levaquin (Levofloxacin) is good for treating many bacterial infections and is available as generic. However, it can cause damage to your tendons, and make your skin more sensitive to the sun.
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Coupons for Keflex
Best available price for 40 (500mg) capsules of cephalexin
Coupons for Levaquin
Best available price for 10 (500mg) tablets of levofloxacin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.08Keflex
Reviews for Keflex (cephalexin)
64%
of people (All ages) say Keflex (cephalexin) is worth it
48%
say it works well
14%
say it's a big hassle
686 reviews
Have you used Keflex (cephalexin)?
Worth itNot sureNot worth it
Reviews for Levaquin (levofloxacin)
53%
-11% worse vs. Keflex (cephalexin)
40%
-8% worse vs. Keflex (cephalexin)
31%
-17% worse vs. Keflex (cephalexin)
Have you used Levaquin (levofloxacin)?
Worth itNot sureNot worth it
Side effects
KeflexLevaquin

The Keflex FDA package insert doesn’t have numbers about how common side effects are.

More about Keflex side effects »
  • Nausea 7%
  • Headache 6%
  • Diarrhea 5%
  • Sleep difficulty 4%
  • Dizziness 3%
  • Consitpation 3%
  • Abdominal pain 2%
  • Vomiting 2%
  • Indigestion 2%
  • Rash 2%
More Levaquin side effects »
How it works
KeflexLevaquin
Keflex (cephalexin) is an antibiotic. It kills bacteria by preventing them from making their own protective covering.Levaquin (Levofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
KeflexLevaquin
Prescription only
Prescription only
Available as
KeflexLevaquin
  • Pill
  • Liquid
  • Pill
  • Liquid
Used for
KeflexLevaquin
Risk factors for serious side effects
KeflexLevaquin
  • Weakened immune system
  • Not taking Keflex (cephalexin) correctly
  • History of penicillin or cephalosporin allergies
Detailed Keflex (cephalexin) risks & warnings »
  • Over 60 years of age
  • On long-term steroid use
  • Heart, kidney, or lung transplant
  • History of liver disease
  • Seizures
Detailed Levaquin (levofloxacin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
KeflexLevaquin
  • Can be taken with or without food.
  • Can take with or without food.
No food related info.
Kidneys and liver
KeflexLevaquin
No kidneys and liver related info.
  • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
Pain
KeflexLevaquin
No pain related info.
  • If you notice pain in your Achilles tendons, contact your doctor.
  • If you notice redness/inflammation, pain or swelling in your joints or muscles, especially in the Achilles tendon, contact your doctor immediately.
  • Talk to your doctor immediately if you start to feel burning, tingling, numbness, pain or you can't tolerate heat or cold. This could be a sign of nerve damage. It can happen as soon as you start taking the medication and may not go away if you stop it.
Upsides and benefits
KeflexLevaquin
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Can be taken with or without food.
  • Generally few side effects compared with other antibiotics.
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
Downsides and risks
KeflexLevaquin
  • Can cause diarrhea.
  • You may need to take Keflex (cephalexin) 2 to 4 times a day, which can be hard to remember.
  • If you're allergic to penicillins or other antibiotics, you might not be able to take this medicine.
  • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
  • Levofloxacin can make your skin more sensitive to the sun.
  • Can't be used if you've ever had myasthenia gravis.
  • You have to space out any medications with aluminum, magnesium or zinc by at least 2 hours.
  • Can cause changes in taste, headaches, and insomnia.
Tips from our pharmacists for people taking the medication
KeflexLevaquin
  • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance.
  • Store the suspension in the refrigerator. Shake well before using, and discard the bottle after 14 days.
  • Can take with or without food.
  • If you notice pain in your Achilles tendons, contact your doctor.
  • Wear sunscreen if you're going to be out in the sun.
  • Take the medication exactly how the doctor tells you to.
  • Take this medication with plenty of fluids.
  • Space out any medications containing aluminum, magnesium or zinc by at least 2 hours.
  • Can cause diarrhea, nausea or vomiting.
  • Can cause changes in taste, headaches and insomnia.
Learn more
More about KeflexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Keflex (cephalexin)?
Worth itNot sureNot worth it
More about LevaquinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Levaquin (levofloxacin)?
Worth itNot sureNot worth it