Compare Klonopin vs. Buspar

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Klonopin
(Clonazepam)

Buspar
(Buspirone)

Controls seizures and helps you relax. Klonopin (Clonazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and to treat seizures. Less severe withdrawal symptoms compared to similar drugs.Helps you relax. Buspar (Buspirone) is effective for treating Generalized Anxiety Disorder (GAD), and less effective for short-term use.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.18Klonopin
Reviews for Klonopin (Clonazepam)
70%
of people (All ages) say Klonopin (Clonazepam) is worth it
52%
say it works well
14%
say it's a big hassle
767 reviews
Have you used Klonopin (Clonazepam)?
Worth itNot sureNot worth it
Reviews for Buspar (Buspirone)
46%
-24% worse vs. Klonopin (Clonazepam)
45%
-7% worse vs. Klonopin (Clonazepam)
22%
-8% worse vs. Klonopin (Clonazepam)
Have you used Buspar (Buspirone)?
Worth itNot sureNot worth it
Side effects
KlonopinBuspar
  • Drowsiness 50%
  • Lack of muscle coordination 30%
  • Behavior problems 25%
  • Ear, nose, or throat infection 6%
  • Fatigue 5%
  • Low mood disorder 6%
  • Dizziness 1%
  • Vaginal inflammation 3%
  • Sinus inflammation 1%
  • Inflammation inside the nose 2%
More Klonopin side effects »
  • Dizziness 9%
  • Any side effect 10%
  • Drowsiness 1%
  • Nausea 3%
  • Headache 3%
  • Nervousness 4%
  • Central nervous system disturbances 3%
More Buspar side effects »
How it works
KlonopinBuspar
Klonopin (Clonazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Buspar (Buspirone) is an anti-anxiety medication. It's used to stabilize chemicals in the brain that control mood and nervousness.
Type of medication
KlonopinBuspar
Prescription only
Prescription only
Available as
KlonopinBuspar
  • Pill
  • Dissolving tablet
  • Pill
Used for
KlonopinBuspar
Risk factors for serious side effects
KlonopinBuspar
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
    • Alcohol
    • Taking other medicines that make you less alert
      Detailed Klonopin (Clonazepam) risks & warnings »
      • Taking with MAOIs
      • Taking with Zyvox or methylene blue
      • Taking with or converting from benzodiazepine medicines
      • Duration of treatment
      Detailed Buspar (Buspirone) risks & warnings »
      Pregnancy

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Alcohol
      KlonopinBuspar
      • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
      • Not safe to use with alcohol.
      • Avoid alcohol when taking Buspar (Buspirone).
      Food
      KlonopinBuspar
      No food related info.
      • Be consistent in taking Buspar (Buspirone) with or without food.
      Sleep
      KlonopinBuspar
      • Can cause memory problems, drowsiness, dizziness, and confusion.
      • Can cause dizziness, drowsiness, and salivation.
      • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
      Upsides and benefits
      KlonopinBuspar
      • Effective at relieving short-term anxiety and sleeplessness.
      • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
      • Can be used alone or with other medicines to treat seizures.
      • Less severe withdrawal symptoms compared to other benzodiazepines.
      • Buspar (Buspirone) works very well to control the symptoms of generalized anxiety syndrome (GAD).
      • Buspar (Buspirone) doesn't cause physical dependence or withdrawal symptoms.
      • Buspar (Buspirone) is only available as a generic, so the price can be pretty cheap.
      Downsides and risks
      KlonopinBuspar
      • Can cause memory problems, drowsiness, dizziness, and confusion.
      • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
      • Most people find that it gets less effective over time.
      • Buspar (Buspirone) can take as long as four weeks to become fully effective.
      • Not as effective for short-term anxiety conditions or panic disorders.
      • Most people find that it loses effectiveness over long periods of time.
      • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
      Tips from our pharmacists for people taking the medication
      KlonopinBuspar
      • For the first week, avoid activities that require you to be alert.
      • Can cause dizziness, drowsiness, and salivation.
      • Report any confusion or inability to control muscle movements to your doctor.
      • Not safe to use with alcohol.
      • Take doses at about the same time each day.
      • It can take several weeks to get the full effect.
      • Don't eat or drink grapefruit juice when using Buspar (Buspirone).
      • Don't use Buspar (Buspirone) within two weeks of using an MAO inhibitor (like Eldepryl, Parnate, or Marplan).
      • Be consistent in taking Buspar (Buspirone) with or without food.
      • Avoid alcohol when taking Buspar (Buspirone).
      Learn more
      More about KlonopinSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Klonopin (Clonazepam)?
      Worth itNot sureNot worth it
      More about BusparSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Buspar (Buspirone)?
      Worth itNot sureNot worth it