Compare Klonopin vs. Lunesta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Klonopin
(clonazepam)

Lunesta
(eszopiclone)

Controls seizures and helps you relax. Klonopin (Clonazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and to treat seizures. Less severe withdrawal symptoms compared to similar drugs.Helps you sleep. Lunesta (Eszopiclone) is good for falling asleep and staying asleep. Not as habit-forming as some sleep medicines, but more likely to cause withdrawal symptoms if you stop suddenly.
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Coupons for Klonopin
Best available price for 60 (0.5mg) tablets of clonazepam
Coupons for Lunesta
Best available price for 30 (3mg) tablets of lunesta
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.18Klonopin
Reviews for Klonopin
70%
of people (All ages) say Klonopin is worth it
52%
say it works well
14%
say it's a big hassle
767 reviews
Have you used Klonopin (clonazepam)?
Worth itNot sureNot worth it
Reviews for Lunesta
55%
+15% better vs. Klonopin
36%
+16% better vs. Klonopin
17%
+3% better vs. Klonopin
592 reviews
Have you used Lunesta (eszopiclone)?
Worth itNot sureNot worth it
Side effects
KlonopinLunesta
  • Drowsiness 50%
  • Lack of muscle coordination 30%
  • Behavior problems 25%
  • Ear, nose, or throat infection 6%
  • Fatigue 5%
  • Low mood disorder 6%
  • Dizziness 1%
  • Vaginal inflammation 3%
  • Sinus inflammation 1%
  • Inflammation inside the nose 2%
More Klonopin side effects »
  • Headache 8%
  • Unpleasant taste 14%
  • Drowsiness 7%
  • Dizziness 1%
  • Nausea 1%
  • Infection 2%
  • Dry mouth 2%
  • Nervousness 2%
  • Low mood disorder 4%
More Lunesta side effects »
How it works
KlonopinLunesta
Klonopin (Clonazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Lunesta (Eszopiclone) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.
Type of medication
KlonopinLunesta
Prescription onlyPrescription only
Available as
KlonopinLunesta
  • Pill
  • Dissolving tablet
  • Pill
Used for
KlonopinLunesta
Risk factors for serious side effects
KlonopinLunesta
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
  • Alcohol
Detailed Klonopin (clonazepam) risks & warnings »
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep.
  • Undiagnosed psychiatric conditions
Detailed Lunesta (eszopiclone) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
KlonopinLunesta
  • Not safe to use with alcohol.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Avoid alcohol and drugs.
  • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
Sleep
KlonopinLunesta
  • Can cause dizziness, drowsiness, and salivation.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Lunesta (Eszopiclone) make you feel drowsy and sleepy, leading to falls and severe injuries. This is especially a risk if your older. Falls from sleep medicines like Lunesta (Eszopiclone) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medicine that affects your nervous system or have issues with falls in the past. Check with your doctor first.
  • Only take it if you have time to sleep for at least 7 hours.
  • Can cause headache, drowsiness, and dizziness.
  • Effective at helping people fall asleep faster and sleep longer.
Upsides and benefits
KlonopinLunesta
  • Effective at relieving short-term anxiety and sleeplessness.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
  • Can be used alone or with other medicines to treat seizures.
  • Less severe withdrawal symptoms compared to other benzodiazepines.
  • Effective at helping people fall asleep faster and sleep longer.
  • Not as habit-forming, so you can use it for longer than most other sleep medicines.
Downsides and risks
KlonopinLunesta
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Most people find that it gets less effective over time.
  • More likely to cause withdrawal symptoms if you stop taking it suddenly.
  • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
  • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
Tips from our pharmacists for people taking the medication
KlonopinLunesta
  • For the first week, avoid activities that require you to be alert.
  • Can cause dizziness, drowsiness, and salivation.
  • Report any confusion or inability to control muscle movements to your doctor.
  • Not safe to use with alcohol.
  • Take 30 to 45 minutes before bedtime.
  • Only take it if you have time to sleep for at least 7 hours.
  • Very addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
  • Can cause headache, drowsiness, and dizziness.
  • Can cause sleep-walking, sleep-driving, and sleep-eating.
  • Works best if taken without food.
  • Avoid alcohol and drugs.
  • Withdrawal symptoms usually resolve in 1 to 2 nights.
  • Report any confusion or changes in thoughts or behavior.
Learn more
More about KlonopinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Klonopin (clonazepam)?
Worth itNot sureNot worth it
More about LunestaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lunesta (eszopiclone)?
Worth itNot sureNot worth it