Compare Klonopin vs. Unisom

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Klonopin
(clonazepam)

Unisom Sleeptabs
(doxylamine)

Controls seizures and helps you relax. Klonopin (Clonazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety, and to treat seizures. Less severe withdrawal symptoms compared to similar drugs.Treats allergy symptoms and helps you sleep. Unisom Sleeptabs (Doxylamine) can help you get a good night's sleep, but you can have a hard time waking up if you don't give yourself enough time to sleep.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Klonopin
Best available price for 60 (0.5mg) tablets of clonazepam
Coupons for Unisom
Best available price for 30 (50mg) capsules of unisom
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.18Klonopin
Reviews for Klonopin
70%
of people (All ages) say Klonopin is worth it
52%
say it works well
14%
say it's a big hassle
767 reviews
Have you used Klonopin (clonazepam)?
Worth itNot sureNot worth it
Reviews for Unisom
58%
+12% better vs. Klonopin
32%
+20% better vs. Klonopin
11%
-3% worse vs. Klonopin
585 reviews
Have you used Unisom Sleeptabs (doxylamine)?
Worth itNot sureNot worth it
Side effects
KlonopinUnisom
  • Drowsiness 50%
  • Lack of muscle coordination 30%
  • Behavior problems 25%
  • Ear, nose, or throat infection 6%
  • Fatigue 5%
  • Low mood disorder 6%
  • Dizziness 1%
  • Vaginal inflammation 3%
  • Sinus inflammation 1%
  • Inflammation inside the nose 2%
More Klonopin side effects »

We haven’t found good data for Unisom side effects.

FDA side effect reports for Unisom »
How it works
KlonopinUnisom
Klonopin (Clonazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.Unisom Sleeptabs (Doxylamine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions. It also makes you sleepy.
Type of medication
KlonopinUnisom
Prescription onlyPrescription or OTC
Available as
KlonopinUnisom
  • Pill
  • Dissolving tablet
  • Pill
  • Chewable tablet
  • Liquid
Used for
KlonopinUnisom
Risk factors for serious side effects
KlonopinUnisom
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
  • Alcohol
Detailed Klonopin (clonazepam) risks & warnings »
  • Using other drugs with similar ingredients
  • Age 65 years or older
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Children age 6 years or younger
Detailed Unisom Sleeptabs (doxylamine) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
KlonopinUnisom
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Not safe to use with alcohol.
  • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
  • Don't take it with alcohol or other drugs that make you sleepy.
Sleep
KlonopinUnisom
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can cause dizziness, drowsiness, and salivation.
  • Not habit-forming like other sleep aids can be.
Upsides and benefits
KlonopinUnisom
  • Effective at relieving short-term anxiety and sleeplessness.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
  • Can be used alone or with other medicines to treat seizures.
  • Less severe withdrawal symptoms compared to other benzodiazepines.
  • Works well to help you fall asleep and doesn't make you feel groggy the next morning.
  • Has fewer side effects than prescription sleep aid medications.
  • Available over the counter without a prescription.
  • Not habit-forming like other sleep aids can be.
Downsides and risks
KlonopinUnisom
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Most people find that it gets less effective over time.
  • Shouldn't be used unless you have a full night to sleep.
  • You shouldn't drive after taking Unisom Sleeptabs (Doxylamine) until you know how it affects you.
  • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
  • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleeptabs (Doxylamine).
Tips from our pharmacists for people taking the medication
KlonopinUnisom
  • For the first week, avoid activities that require you to be alert.
  • Can cause dizziness, drowsiness, and salivation.
  • Report any confusion or inability to control muscle movements to your doctor.
  • Not safe to use with alcohol.
  • Starts working in 30 minutes.
  • Unisom Sleeptabs (Doxylamine) makes you tired, so take it before you go to sleep.
  • Don't take it with alcohol or other drugs that make you sleepy.
  • If you need to use it for more than a few weeks, talk with your doctor. A different medication might work better for you long-term.
  • Unisom comes in two different generic forms, doxylamine (Unisom SleepTabs) and diphenhydramine (other Unisom products). Both are antihistamines that help you sleep.
Learn more
More about KlonopinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Klonopin (clonazepam)?
Worth itNot sureNot worth it
More about UnisomSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Unisom Sleeptabs (doxylamine)?
Worth itNot sureNot worth it