Compare Lamictal vs. Depakote

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lamictal (Lamotrigine)

Prescription only

Depakote (divalproex)

Prescription only
Prevents seizures and stabilizes mood.

Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.

3.7/ 5 average rating with 184 reviewsforLamictal
Treats and prevents seizures, and stabilizes mood.

Depakote (divalproex) is good for long-term prevention of seizures, manic episodes in bipolar disorder, and migraines.

3.3/ 5 average rating with 97 reviewsforDepakote
Upsides
  • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
  • Works best for partial, tonic-clonic, and absence seizures.
  • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
  • Doesn't require routine blood tests.
  • Lowers the frequency of seizures, especially for people with absence seizures or complex partial seizures.
  • Depakote (divalproex) is a first-line treatment to stabilize mood for people with bipolar disorder.
  • Depakote (divalproex) is helpful for preventing frequent migraines.
  • The sprinkle pill can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing.
  • Depakote (divalproex) is available as a generic.
Downsides
  • Can cause double vision, dizziness, sleepiness, and headache.
  • Has the risk of a rare but life-threatening rash.
  • Can make hormonal birth control less effective.
  • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
  • It can take 3 to 4 weeks before you feel the full effects of Depakote (divalproex).
  • Depakote (divalproex) is not a good medication for people with liver problems.
  • Requires regular blood tests to see how the medication is affecting your body.
  • Depakote (divalproex) can make you bleed more easily.
Used for
Dosage forms
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
  • Extended release pill
  • Delayed release pill
Price
No pricing information available
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Reviews
184 reviews so far
66%
saidit'sworth it
58%
saiditworked well
18%
saidit'sa big hassle

Have you used Lamictal (Lamotrigine)?

Leave a review
97 reviews so far
46%
saidit'sworth it
40%
saiditworked well
27%
saidit'sa big hassle

Have you used Depakote (divalproex)?

Leave a review
Side effects
36possible side effects
  • Dizziness
    38%
  • Headache
    28%
  • Diplopia
    28%
  • Ataxia
    22%
  • Nausea
    19%
  • Blurred vision
    16%
  • Somnolence
    14%
  • Rhinitis
    14%
  • Pharyngitis
    10%
  • Rash
    10%
  • Vomiting
    9%
  • Cough increased
    8%
  • Flu syndrome
    7%
  • Dysmenorrhea
    7%
  • Fever
    6%
  • Diarrhea
    6%
  • Incoordination
    6%
  • Insomnia
    6%
  • Abdominal pain
    5%
  • Dyspepsia
    5%
  • Constipation
    4%
  • Tremor
    4%
  • Depression
    4%
  • Anxiety
    4%
  • Vaginitis
    4%
  • Convulsion
    3%
  • Irritability
    3%
  • Speech disorder
    3%
  • Pruritus
    3%
  • Vision abnormality
    3%
  • Neck pain
    2%
  • Reaction aggravated (seizure exacerbation)
    2%
  • Anorexia
    2%
  • Arthralgia
    2%
  • Concentration disturbance
    2%
  • Amenorrhea
    2%
See more detailed side effects
9possible side effects
  • Nausea
    22%
  • Sleepiness
    19%
  • Dizziness
    12%
  • Vomiting
    12%
  • Accidental injury
    11%
  • Feeling weak
    10%
  • Abdominal pain
    9%
  • Upset stomach
    9%
  • Rash
    6%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • History of depression
  • Serious skin rash
    • People also taking Depakote
    • Taking more than the prescribed dose
    • Increasing the dose too quickly
  • Serious allergic reactions
  • Blood disorders
  • Meningitis
  • Interactions with birth control pills
    • Taking birth control pills
  • Withdrawal seizures
    • Stopping Lamictal (Lamotrigine) suddenly
See more detailed risks and warnings
  • Harm to fetus
  • Liver damage
    • Children under age 2
    • History of metabolic disorders
    • Severe seizure disorder
    • Brain disease
    • History of liver problems
  • Pancreas problems
  • Suicidal thoughts or behavior
    • History of depression
  • Increased bleeding
  • Mental changes
    • History of metabolic disorders
    • People also taking Topamax
See more detailed risks and warnings