Compare Lamictal vs. Imitrex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lamictal
(lamotrigine)

Imitrex
(sumatriptan)

Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.Treats migraine headaches. Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.
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Prices and coupon for 30 (100mg) tablets of lamotrigine
Coupons for
Prices and coupon for 1 (9 tablets of 100mg) dose pack of sumatriptan
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.11Lamictal
Reviews for Lamictal (lamotrigine)
66%
of people (All ages) say Lamictal (lamotrigine) is worth it
58%
say it works well
18%
say it's a big hassle
184 reviews
Have you used Lamictal (lamotrigine)?
Worth itNot sureNot worth it
Reviews for Imitrex (sumatriptan)
74%
+8% better vs. Lamictal (lamotrigine)
68%
+10% better vs. Lamictal (lamotrigine)
19%
-1% worse vs. Lamictal (lamotrigine)
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it
Side effects
LamictalImitrex
  • Dizziness 25%
  • Headache 9%
  • Double vision 21%
  • Lack of muscle coordination 16%
  • Nausea 9%
  • Blurred vision 11%
  • Inflammation inside the nose 5%
  • Drowsiness 7%
  • Sore throat 1%
  • Rash 5%
More Lamictal side effects »
  • Pain and other pressure sensations 2%
  • Atypical sensations 1%
  • Paresthesia (all types) 1%
  • Sensation warm/cold 1%
  • Pain - location specified 1%
  • Malaise/fatigue 2%
  • Chest - pain/tightness/pressure and/or heaviness 1%
  • Neck/throat/jaw - pain/ tightness/pressure 2%
  • Other - pressure/tightness/ heaviness 1%
  • Vertigo 2%
More Imitrex side effects »
How it works
LamictalImitrex
Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.Imitrex (Sumatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.
Type of medication
LamictalImitrex
Prescription only
Prescription only
Available as
LamictalImitrex
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
  • Injection
  • Nasal spray
Used for
LamictalImitrex
Risk factors for serious side effects
LamictalImitrex
  • History of depression
  • People also taking Depakote
  • Taking more than the prescribed dose
  • Increasing the dose too quickly
        • Taking birth control pills
        • Stopping Lamictal (Lamotrigine) suddenly
        Detailed Lamictal (lamotrigine) risks & warnings »
        • History of heart problems
        • High blood pressure
        • High cholesterol
        • Diabetes
        • Being overweight or obese
        • Smoking
        • History of heart problems
        • High blood pressure
        • High cholesterol
        • Diabetes
        • Being overweight or obese
        • Smoking
          • Patients taking SSRIs and SNRIs
          • History of high blood pressure
          • History of seizures
          Detailed Imitrex (sumatriptan) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Food
          LamictalImitrex
          • Take with food to avoid upset stomach.
          No food related info.
          Sleep
          LamictalImitrex
          No sleep related info.
          • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
          Upsides and benefits
          LamictalImitrex
          • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
          • Works best for partial, tonic-clonic, and absence seizures.
          • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
          • Doesn't require routine blood tests.
          • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
          • A combination of forms can be used if symptoms do not improve.
          • The nasal spray and injectable forms work very quickly.
          • It's generally safe to use if you are pregnant.
          • Comes in a generic form, so it can be pretty cheap.
          Downsides and risks
          LamictalImitrex
          • Can cause double vision, dizziness, sleepiness, and headache.
          • Has the risk of a rare but life-threatening rash.
          • Can make hormonal birth control less effective.
          • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
          • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
          • Does not prevent migraine headaches; it only treats them once they start.
          • Must wait 1 hour before using second injection.
          • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
          • Need to have your blood pressure checked often, especially if you're pregnant.
          Tips from our pharmacists for people taking the medication
          LamictalImitrex
          • Follow dose adjustments set by your doctor to minimize skin rash.
          • Take with food to avoid upset stomach.
          • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
          • Makes hormonal birth control less effective.
          • Takes 4 to 6 weeks to feel full effects on mood.
          • Take it as soon as your headache starts.
          • If you use the nasal spray, be sure to blow your nose before using it.
          • If you use the patch, put it on a dry area free of scars, tattoos, or other cuts and scrapes. Be sure to press the button to activate it.
          • If you use the injection, you can use a second injection if you still have a headache after an hour. If you have symptoms 2 hours after the injection, switch to the pill version.
          • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
          • Lie down in a dark room after taking Imitrex (Sumatriptan) to help ease the pain.
          Learn more
          More about LamictalSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Lamictal (lamotrigine)?
          Worth itNot sureNot worth it
          More about ImitrexSide effectsReviews & ratingsFDA package insert
          Have you used Imitrex (sumatriptan)?
          Worth itNot sureNot worth it