Compare Lamictal vs. Keppra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lamictal
(lamotrigine)

Keppra
(levetiracetam)

Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.Prevents seizures. Keppra (Levetiracetam) is effective for preventing seizures in people with epilepsy. Compared to other anti-seizure medications, it has few drug interactions and you don’t need to get your levels checked.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.11Lamictal
Reviews for Lamictal
66%
of people (All ages) say Lamictal is worth it
58%
say it works well
18%
say it's a big hassle
184 reviews
Have you used Lamictal (lamotrigine)?
Worth itNot sureNot worth it
Reviews for Keppra
33%
+33% better vs. Lamictal
81%
-23% worse vs. Lamictal
33%
+15% better vs. Lamictal
Have you used Keppra (levetiracetam)?
Worth itNot sureNot worth it
Side effects
LamictalKeppra
  • Dizziness 25%
  • Headache 9%
  • Diplopia 21%
  • Ataxia 16%
  • Nausea 9%
  • Blurred vision 11%
  • Rhinitis 5%
  • Somnolence 7%
  • Pharyngitis 1%
  • Rash 5%
More Lamictal side effects »
  • Headache 4%
  • Asthenia 6%
  • Vomiting 3%
  • Any side effect 3%
  • Nasopharyngitis 3%
  • Somnolence 7%
  • Infection 5%
  • Irritability 12%
  • Neck pain 6%
  • Pharyngitis 7%
More Keppra side effects »
How it works
LamictalKeppra
Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.Keppra (Levetiracetam) is an antiepileptic medication. It prevents seizures by helping regulate neurotransmitters in the brain.
Type of medication
LamictalKeppra
Prescription onlyPrescription only
Available as
LamictalKeppra
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
  • Extended release
  • Liquid
Used for
LamictalKeppra
Risk factors for serious side effects
LamictalKeppra
  • History of depression
  • People also taking Depakote
  • Taking more than the prescribed dose
  • Increasing the dose too quickly
  • Taking birth control pills
Detailed Lamictal (lamotrigine) risks & warnings »
  • History of depression
  • Starting the first month of therapy
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Stopping Keppra (Levetiracetam) suddenly
Detailed Keppra (levetiracetam) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
LamictalKeppra
  • Take with food to avoid upset stomach.
No food related info.
Kidneys and liver
LamictalKeppra
No kidneys and liver related info.
  • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
Sleep
LamictalKeppra
No sleep related info.
  • Taking Keppra (Levetiracetam) can make you feel sleepy, dizzy, and affect your coordination. Avoid activities that require you to be alert, such as driving a car or operating machinery, until you know how Keppra (Levetiracetam) affects you.
  • You can experience drowsiness, weakness, dizziness, or respiratory infections while on this.
Upsides and benefits
LamictalKeppra
  • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
  • Works best for partial, tonic-clonic, and absence seizures.
  • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
  • Doesn't require routine blood tests.
  • Lowers the frequency of seizures, including partial-onset, generalized tonic-clonic, and myoclonic seizures.
  • Unlike many other medications for epilepsy, this has very few drug interactions, so your other medicines shouldn't be affected.
  • If you have trouble swallowing tablets, Keppra (Levetiracetam) is also available as an oral solution.
  • You won’t need to get regular blood tests to check the drug levels in your body.
Downsides and risks
LamictalKeppra
  • Can cause double vision, dizziness, sleepiness, and headache.
  • Has the risk of a rare but life-threatening rash.
  • Can make hormonal birth control less effective.
  • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
  • It’s important to take your dose on time so that Keppra (Levetiracetam) has consistent levels in your body.
  • May not be the best drug to take if you have a history of psychiatric issues, such as depression or bipolar disorder.
  • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
  • Keppra (Levetiracetam) is only FDA-approved to be taken with other medicines to treat epilepsy.
Tips from our pharmacists for people taking the medication
LamictalKeppra
  • Follow dose adjustments set by your doctor to minimize skin rash.
  • Take with food to avoid upset stomach.
  • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
  • Makes hormonal birth control less effective.
  • Takes 4 to 6 weeks to feel full effects on mood.
  • You can experience drowsiness, weakness, dizziness, or respiratory infections while on this.
  • If you start having skin rashes or changes in your mood, tell your doctor immediately.
  • If you need to stop taking Keppra (Levetiracetam), do so over at least one week to prevent withdrawal seizures.
  • If you are taking the oral solution, use the measuring device given with the medicine. Don’t use your household tablespoons to measure.
  • Don’t crush or cut this medicine before taking it, or else you’ll have dangerously high levels of this drug in your body.
Learn more
More about LamictalSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lamictal (lamotrigine)?
Worth itNot sureNot worth it
More about KeppraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Keppra (levetiracetam)?
Worth itNot sureNot worth it