Compare Lamictal vs. Neurontin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lamictal
(Lamotrigine)

Neurontin
(Gabapentin)

Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.178571428571429Lamictal
Reviews for Lamictal (Lamotrigine)
67%
of people say Lamictal (Lamotrigine) is worth it
58%
say it works well
19%
say it's a big hassle
Reviews for Neurontin (Gabapentin)
57%
10% vs. Lamictal (Lamotrigine)
39%
19% vs. Lamictal (Lamotrigine)
19%
Same vs. Lamictal (Lamotrigine)
Side effects
LamictalNeurontin
  • Double vision 41%
  • Dizziness 27%
  • Lack of muscle coordination 18%
  • Blurred vision 15%
  • Nausea 14%
  • Vomiting 14%
  • Headache 10%
  • Inflammation inside the nose 5%
  • Sleep difficulty 4%
  • Incoordination 4%
More Lamictal side effects »
  • Dizziness 21%
  • Drowsiness 16%
  • Lack of muscle coordination 7%
  • Leg or ankle swelling 6%
  • Fatigue 6%
  • Hostility 5%
  • Involuntary eye movement 4%
  • Double vision 4%
  • Tremor 4%
  • Dry mouth 4%
More Neurontin side effects »
How it works
LamictalNeurontin
Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.
Type of medication
LamictalNeurontin
AnticonvulsantPrescription only
Anticonvulsant
GABA analog
Prescription only
Available as
LamictalNeurontin
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
  • Oral solution
Used for (click to learn more)
LamictalNeurontin
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Lamictal (Lamotrigine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Neurontin (Gabapentin)
Risk factors for serious side effects
LamictalNeurontin
  • History of depression
  • People also taking Depakote
  • Taking more than the prescribed dose
  • Increasing the dose too quickly
        • Taking birth control pills
        • Stopping Lamictal (Lamotrigine) suddenly
        Detailed Lamictal (Lamotrigine) risks & warnings »
          • Children ages 3 to 12
            • Taking with alcohol or drugs
            • Stopping Neurontin (Gabapentin) suddenly
            Detailed Neurontin (Gabapentin) risks & warnings »
            Pregnancy category
            LamictalNeurontin
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.
            • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
            Food
            • Take with food to avoid upset stomach.
            • Take the extended-release tablet with food.
            Kidneys and liver
            No specific kidneys and liver-related info.No specific kidneys and liver-related info.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.
            • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
            Weight
            No specific weight-related info.No specific weight-related info.
            Upsides and benefits
            LamictalNeurontin
            • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
            • Works best for partial, tonic-clonic, and absence seizures.
            • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
            • Doesn't require routine blood tests.
            • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
            • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
            • It's available as a generic, so it's less expensive than similar medications.
            Downsides and risks
            LamictalNeurontin
            • Can cause double vision, dizziness, sleepiness, and headache.
            • Has the risk of a rare but life-threatening rash.
            • Can make hormonal birth control less effective.
            • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
            • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
            • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
            Tips from our pharmacists for people taking the medication
            LamictalNeurontin
            • Follow dose adjustments set by your doctor to minimize skin rash.
            • Take with food to avoid upset stomach.
            • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
            • Makes hormonal birth control less effective.
            • Takes 4 to 6 weeks to feel full effects on mood.
            • Side effects are common, but usually manageable.
            • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
            • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
            • Take the extended-release tablet with food.
            • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
            Learn more
            More about LamictalSide effectsReviews & ratingsAlternativesFDA package insert
            More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert