Lamictal vs. Norpramin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Scroll horizontally → to see comparisons



Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.Coming soon.
How it works
Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.Coming soon.
Type of medication
AnticonvulsantPrescription only
Coming soon.
Available as
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
Used for (click to learn more)
  • Depression
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Lamictal (Lamotrigine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Norpramin (Desipramine)
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Lamictal (Lamotrigine)
of people say Lamictal (Lamotrigine) is worth it
say it works well
say it's a big hassle
Side effects
  • Double vision 41%
  • Dizziness 27%
  • Lack of muscle coordination 18%
  • Blurred vision 15%
  • Nausea 14%
  • Vomiting 14%
  • Headache 10%
  • Inflammation inside the nose 5%
  • Sleep difficulty 4%
  • Incoordination 4%
More Lamictal side effects »

We haven’t found good data for Norpramin side effects.

FDA side effect reports for Norpramin »
Risk factors for serious side effects
  • History of depression
  • People also taking Depakote
  • Taking more than the prescribed dose
  • Increasing the dose too quickly
        • Taking birth control pills
        • Stopping Lamictal (Lamotrigine) suddenly
        Detailed Lamictal (Lamotrigine) risks & warnings »
        Coming soon.
        Pregnancy category
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        NFDA pregnancy category (Unknown)

        The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

        See the FDA package insert
        No specific alcohol-related info.No specific alcohol-related info.
        • Take with food to avoid upset stomach.
        No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        No specific sex-related info.No specific sex-related info.
        No specific sleep-related info.No specific sleep-related info.
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
        • Works best for partial, tonic-clonic, and absence seizures.
        • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
        • Doesn't require routine blood tests.
        Coming soon.
        Downsides and risks
        • Can cause double vision, dizziness, sleepiness, and headache.
        • Has the risk of a rare but life-threatening rash.
        • Can make hormonal birth control less effective.
        • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
        Coming soon.
        Tips from our pharmacists for people taking the medication
        • Follow dose adjustments set by your doctor to minimize skin rash.
        • Take with food to avoid upset stomach.
        • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
        • Makes hormonal birth control less effective.
        • Takes 4 to 6 weeks to feel full effects on mood.
        Coming soon.
        Learn more
        More about LamictalSide effectsReviews & ratingsAlternativesFDA package insert
        More about NorpraminSide effectsReviews & ratingsFDA package insert