Compare Lamictal vs. Propranolol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lamictal
(Lamotrigine)

Inderal
(Propranolol)

Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.Lowers blood pressure and controls heart rate. Inderal (Propranolol) is good for treating many heart problems and other problems in the body, but it has more side effects than other beta blockers. You can't miss doses.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.178571428571429Lamictal
Reviews for Lamictal (Lamotrigine)
67%
of people say Lamictal (Lamotrigine) is worth it
58%
say it works well
19%
say it's a big hassle
Reviews for Inderal (Propranolol)
62%
5% vs. Lamictal (Lamotrigine)
58%
Same vs. Lamictal (Lamotrigine)
17%
+2% vs. Lamictal (Lamotrigine)
Side effects
LamictalPropranolol
  • Double vision 41%
  • Dizziness 27%
  • Lack of muscle coordination 18%
  • Blurred vision 15%
  • Nausea 14%
  • Vomiting 14%
  • Headache 10%
  • Inflammation inside the nose 5%
  • Sleep difficulty 4%
  • Incoordination 4%
More Lamictal side effects »
  • Dizziness 5%
  • Fatigue 4%
More Propranolol side effects »
How it works
LamictalPropranolol
Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.Inderal (Propranolol) is an alpha and beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
LamictalPropranolol
AnticonvulsantPrescription only
Antihypertensive
Beta blocker
Prescription only
Available as
LamictalPropranolol
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
  • Extended release
  • Liquid
Used for (click to learn more)
LamictalPropranolol
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Lamictal (Lamotrigine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Inderal (Propranolol)
Risk factors for serious side effects
LamictalPropranolol
  • History of depression
  • People also taking Depakote
  • Taking more than the prescribed dose
  • Increasing the dose too quickly
        • Taking birth control pills
        • Stopping Lamictal (Lamotrigine) suddenly
        Detailed Lamictal (Lamotrigine) risks & warnings »
        • Suddenly stopping Inderal (Propranolol)
          • Major surgery requiring anesthesia
          • Diabetes
            • Concurrent use of non-dihydropyridine calcium channel blockers, digoxin or clonidine
              Detailed Inderal (Propranolol) risks & warnings »
              Pregnancy category
              LamictalPropranolol
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.No specific alcohol-related info.
              Food
              • Take with food to avoid upset stomach.
              No specific food-related info.
              Kidneys and liver
              No specific kidneys and liver-related info.No specific kidneys and liver-related info.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              No specific weight-related info.
              • Cases of heart failure due to taking Inderal (Propranolol) have been reported. Tell your doctor if you noticed increased swelling around your legs or ankles, sudden weight gain or sudden shortness of breath as these may be symptoms of heart failure.
              Upsides and benefits
              LamictalPropranolol
              • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
              • Works best for partial, tonic-clonic, and absence seizures.
              • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
              • Doesn't require routine blood tests.
              • A first-choice treatment to prevent chest pain (angina).
              • A first-choice treatment for heart failure, heart attack, heart valve disorders, and abnormal heart rhythm.
              • Also treats and prevents many non-heart problems, such as tremors, anxiety, migraines, and liver disease symptoms.
              Downsides and risks
              LamictalPropranolol
              • Can cause double vision, dizziness, sleepiness, and headache.
              • Has the risk of a rare but life-threatening rash.
              • Can make hormonal birth control less effective.
              • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
              • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
              • Has more side effects than some beta blockers because it crosses into the brain and central nervous system.
              • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
              • Can hide symptoms of low blood sugar if you're diabetic.
              • You can't miss doses. Stopping Propranolol suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
              Tips from our pharmacists for people taking the medication
              LamictalPropranolol
              • Follow dose adjustments set by your doctor to minimize skin rash.
              • Take with food to avoid upset stomach.
              • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
              • Makes hormonal birth control less effective.
              • Takes 4 to 6 weeks to feel full effects on mood.
              • Can cause dizziness in the first few days.
              • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
              • Can cause insomnia and fatigue.
              • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
              • Don't stop taking this medicine suddenly.
              Learn more
              More about LamictalSide effectsReviews & ratingsAlternativesFDA package insert
              More about PropranololSide effectsReviews & ratingsAlternativesFDA package insert