Compare Lamictal vs. Seroquel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lamictal (Lamotrigine)

Prescription only

Seroquel (quetiapine)

Prescription only
Prevents seizures and stabilizes mood.

Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.

5.1/ 7 average rating with 184 reviewsforLamictal
Helps control your thoughts and mood.

Seroquel (quetiapine) is a effective at treating schizophrenia, mania, and depression but it can cause weight gain and high blood glucose levels.

5.0/ 7 average rating with 250 reviewsforSeroquel
Upsides
  • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
  • Works best for partial, tonic-clonic, and absence seizures.
  • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
  • Doesn't require routine blood tests.
  • Seroquel (quetiapine) is effective at relieving psychotic symptoms and manic episodes.
  • Seroquel (quetiapine) has fewer side effects than most antipsychotic medications.
  • Seroquel (quetiapine) is less likely to cause heart problems compared to some other antipsychotics.
  • Seroquel (quetiapine) is also the least likely to cause Extrapyramidal Symptoms (EPS) – a movement disorder that causes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
Downsides
  • Can cause double vision, dizziness, sleepiness, and headache.
  • Has the risk of a rare but life-threatening rash.
  • Can make hormonal birth control less effective.
  • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
  • Seroquel (quetiapine) has a moderate to high risk of weight gain, elevated cholesterol and/or blood sugar compared to other antipsychotics.
  • You might need routine blood tests to check how Seroquel (quetiapine) is affecting your body.
Used for
Dosage forms
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
  • Extended release
Price
Lowest price near you
$8.7
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Lowest price near you
$8.4
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Reviews
184 
66%
think this treatment is worth it
58%
think this treatment works well
18%
think this treatment is a hassle

Have you used Lamictal (Lamotrigine)?

Leave a review
250 
56%
think this treatment is worth it
50%
think this treatment works well
27%
think this treatment is a hassle

Have you used Seroquel (quetiapine)?

Leave a review
Side effects
10possible side effects
  • Dizziness
    38%
  • Headache
    28%
  • Diplopia
    28%
  • Ataxia
    22%
  • Nausea
    19%
  • Blurred vision
    16%
  • Somnolence
    14%
  • Rhinitis
    14%
  • Pharyngitis
    10%
  • Rash
    10%
See more detailed side effects
10possible side effects
  • Drowsiness
    34%
  • Dry mouth
    19%
  • Headache
    17%
  • Weakness
    10%
  • Constipation
    10%
  • Dizziness
    9%
  • Tremor
    8%
  • Stomach pain
    7%
  • Low blood pressure
    7%
  • Agitation
    6%
See more detailed side effects
Risks and warnings
  • Suicidal thoughts or behavior

    History of depression

  • Serious skin rash

    People also taking Depakote

    ...and 2 more risk factors

  • Interactions with birth control pills

    Taking birth control pills

  • Withdrawal seizures

    Stopping Lamictal (Lamotrigine) suddenly

See more detailed risks and warnings
  • Higher risk of death

    Elderly patients with dementia-related psychosis

  • Suicidal thoughts or behavior

    Children, adolescents, and young adults (<24 years old)

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Metabolic changes (increased blood sugar, high cholesterol and weight gain)

    People with diabetes

    ...and 1 more risk factors

See more detailed risks and warnings