Compare Lamictal vs. Topamax

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lamictal
(Lamotrigine)

Qudexy Xr
(Topiramate)

Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.178571428571429Lamictal
Reviews for Lamictal (Lamotrigine)
67%
of people say Lamictal (Lamotrigine) is worth it
58%
say it works well
19%
say it's a big hassle
Reviews for Qudexy Xr (Topiramate)
54%
13% vs. Lamictal (Lamotrigine)
52%
6% vs. Lamictal (Lamotrigine)
33%
14% vs. Lamictal (Lamotrigine)
Side effects
LamictalTopamax
  • Double vision 41%
  • Dizziness 27%
  • Lack of muscle coordination 18%
  • Blurred vision 15%
  • Nausea 14%
  • Vomiting 14%
  • Headache 10%
  • Inflammation inside the nose 5%
  • Sleep difficulty 4%
  • Incoordination 4%
More Lamictal side effects »
  • Tingling sensation 45%
  • Slowed-down thinking and movements 19%
  • Dizziness 17%
  • Drowsiness 17%
  • Fatigue 17%
  • Change in taste 14%
  • Difficulty with concentration/attention 13%
  • Nervousness 12%
  • Difficulty with memory 11%
  • Vision abnormal 11%
More Topamax side effects »
How it works
LamictalTopamax
Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.
Type of medication
LamictalTopamax
AnticonvulsantPrescription only
AnticonvulsantPrescription only
Available as
LamictalTopamax
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
  • Extended release capsule
Used for (click to learn more)
LamictalTopamax
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Lamictal (Lamotrigine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Qudexy Xr (Topiramate)
Risk factors for serious side effects
LamictalTopamax
  • History of depression
  • People also taking Depakote
  • Taking more than the prescribed dose
  • Increasing the dose too quickly
        • Taking birth control pills
        • Stopping Lamictal (Lamotrigine) suddenly
        Detailed Lamictal (Lamotrigine) risks & warnings »
        • History of depression
          • Children
          • History of metabolic disorders
          • People also taking Depakote
          • Low-carb diet
          • Dehydration
          • Drug interactions
            • Stopping Qudexy Xr (Topiramate) suddenly
            Detailed Qudexy Xr (Topiramate) risks & warnings »
            Pregnancy category
            LamictalTopamax
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            DFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            • Take with food to avoid upset stomach.
            No specific food-related info.
            Kidneys and liver
            No specific kidneys and liver-related info.
            • A few people will get kidney stones.
            • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            No specific weight-related info.
            • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
            Upsides and benefits
            LamictalTopamax
            • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
            • Works best for partial, tonic-clonic, and absence seizures.
            • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
            • Doesn't require routine blood tests.
            • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
            • Helpful in preventing frequent migraine headaches.
            • Doesn't need routine blood tests.
            Downsides and risks
            LamictalTopamax
            • Can cause double vision, dizziness, sleepiness, and headache.
            • Has the risk of a rare but life-threatening rash.
            • Can make hormonal birth control less effective.
            • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
            • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
            • A few people will get kidney stones.
            • Not safe to use if you're pregnant.
            Tips from our pharmacists for people taking the medication
            LamictalTopamax
            • Follow dose adjustments set by your doctor to minimize skin rash.
            • Take with food to avoid upset stomach.
            • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
            • Makes hormonal birth control less effective.
            • Takes 4 to 6 weeks to feel full effects on mood.
            • For the first week, avoid activities that require you to be alert.
            • Don't use if pregnant.
            • Can cause tingling skin sensations and reduced appetite.
            • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
            • Takes 3 to 4 weeks to feel full effects on mood.
            Learn more
            More about LamictalSide effectsReviews & ratingsAlternativesFDA package insert
            More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert