Compare Lamictal vs. Trileptal

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lamictal
(Lamotrigine)

Trileptal
(Oxcarbazepine)

Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.Prevents seizures. Trileptal (Oxcarbazepine) is effective at preventing seizures and you don’t need to get regular blood tests to make sure it’s effective, but it has many drug interactions.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.11Lamictal
Reviews for Lamictal
66%
of people (All ages) say Lamictal is worth it
58%
say it works well
18%
say it's a big hassle
184 reviews
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Have you used Trileptal (Oxcarbazepine)?
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Side effects
LamictalTrileptal
  • Neck pain 1%
  • Reaction aggravated (seizure exacerbation) 1%
  • Anorexia 1%
  • Arthralgia 2%
  • Concentration disturbance 1%
  • Amenorrhea 1%
  • Convulsion 2%
  • Irritability 1%
  • Speech disorder 3%
  • Pruritus 1%
More Lamictal side effects »
  • Dizziness 2%
  • Nausea 2%
  • Rash 2%
  • Falling Down NOS 4%
  • Pain Back 2%
  • Amnesia 2%
  • Coordination Abnormal 2%
  • Tremor 4%
  • Epistaxis 4%
  • Infection Chest 4%
More Trileptal side effects »
How it works
LamictalTrileptal
Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.Trileptal (Oxcarbazepine) is an antiepileptic medication. It reduces seizures by blocking certain types of nerve activity that regulate how your brain cells communicate with each other.
Type of medication
LamictalTrileptal
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
LamictalTrileptal
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
  • Liquid
Used for
LamictalTrileptal
Risk factors for serious side effects
LamictalTrileptal
  • History of depression
  • People also taking Depakote
  • Taking more than the prescribed dose
  • Increasing the dose too quickly
  • Taking birth control pills
Detailed Lamictal (Lamotrigine) risks & warnings »
  • Age 65 or older
  • dehydration
  • Taking diuretics (water pills)
  • Had allergic reaction to Tegretol (carbamazepine)
  • Asian ancestry
Detailed Trileptal (Oxcarbazepine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
LamictalTrileptal
No interactions related info.
  • Interacts with many other medicines and supplements.
Food
LamictalTrileptal
  • Take with food to avoid upset stomach.
  • Trileptal (Oxcarbazepine) can be taken with or without food.
Kidneys and liver
LamictalTrileptal
No kidneys and liver related info.
  • Hepatitis and liver failure have been reported with Trileptal (Oxcarbazepine). However, this is very rare. Call your doctor right away if you start to have clay-colored stools, yellowing of the eyes or skin, dark urine, stomach pain, or if you are eating less than usual without trying to.
  • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
Sleep
LamictalTrileptal
No sleep related info.
  • Trileptal (Oxcarbazepine) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
  • You can experience dizziness, drowsiness, double vision, stomach upset, and trouble with coordination while on this.
  • Can cause difficulty concentrating, tiredness or drowsiness, and problems with coordination.
Upsides and benefits
LamictalTrileptal
  • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
  • Works best for partial, tonic-clonic, and absence seizures.
  • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
  • Doesn't require routine blood tests.
  • Trileptal (Oxcarbazepine) is effective at lowering the frequency of seizures, especially for people with partial seizures.
  • If you have trouble swallowing tablets, Trileptal (Oxcarbazepine) is also available as an oral solution.
  • You won’t need to get regular blood tests to check the drug levels in your body.
  • Available in a generic form.
Downsides and risks
LamictalTrileptal
  • Can cause double vision, dizziness, sleepiness, and headache.
  • Has the risk of a rare but life-threatening rash.
  • Can make hormonal birth control less effective.
  • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
  • It’s important to take your dose on time so that Trileptal (Oxcarbazepine) has steady levels in your body.
  • Interacts with many other medicines and supplements.
  • Can cause difficulty concentrating, tiredness or drowsiness, and problems with coordination.
  • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
  • Being pregnant lowers the levels of Trileptal (Oxcarbazepine), so the medicine might not be as effective at preventing seizures.
Tips from our pharmacists for people taking the medication
LamictalTrileptal
  • Follow dose adjustments set by your doctor to minimize skin rash.
  • Take with food to avoid upset stomach.
  • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
  • Makes hormonal birth control less effective.
  • Takes 4 to 6 weeks to feel full effects on mood.
  • You can experience dizziness, drowsiness, double vision, stomach upset, and trouble with coordination while on this.
  • If you start having skin rashes or thoughts of suicide, tell your doctor immediately.
  • If you need to stop taking Trileptal (Oxcarbazepine), do so over at least one week to prevent withdrawal seizures.
  • Trileptal (Oxcarbazepine) makes birth control and many other medicines less effective.
  • Trileptal (Oxcarbazepine) can be taken with or without food.
  • If you're taking the oral suspension, use the measuring device given with the medicine. Don’t use your household tablespoons to measure.
Learn more
More about LamictalSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lamictal (Lamotrigine)?
Worth itNot sureNot worth it
More about TrileptalSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Trileptal (Oxcarbazepine)?
Worth itNot sureNot worth it