Compare Lamictal vs. Trileptal

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lamictal
(Lamotrigine)

Trileptal
(Oxcarbazepine)

Prevents seizures and stabilizes mood. Lamictal (Lamotrigine) is most useful for treating severe seizure disorders, and for bipolar disorder with more depression symptoms than manic symptoms. Just be careful to increase your dose slowly to avoid skin rash.Prevents seizures. Trileptal (Oxcarbazepine) is effective at preventing seizures and you don’t need to get regular blood tests to make sure it’s effective, but it has many drug interactions.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.178571428571429Lamictal
Reviews for Lamictal (Lamotrigine)
67%
of people say Lamictal (Lamotrigine) is worth it
58%
say it works well
19%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
LamictalTrileptal
  • Double vision 41%
  • Dizziness 27%
  • Lack of muscle coordination 18%
  • Blurred vision 15%
  • Nausea 14%
  • Vomiting 14%
  • Headache 10%
  • Inflammation inside the nose 5%
  • Sleep difficulty 4%
  • Incoordination 4%
More Lamictal side effects »
  • Dizziness 16%
  • Diarrhea 5%
  • Nausea 4%
  • Nervousness 3%
  • Headache 3%
  • Coordination abnormal 2%
  • Pain back 2%
  • Sinus inflammation 2%
  • Rash 2%
  • Amnesia 2%
More Trileptal side effects »
How it works
LamictalTrileptal
Lamictal (Lamotrigine) is an antiepileptic. Researchers don't know exactly how it works, but it seems to calm nerve activity in the brain.Trileptal (Oxcarbazepine) is an antiepileptic medication. It reduces seizures by blocking certain types of nerve activity that regulate how your brain cells communicate with each other.
Type of medication
LamictalTrileptal
AnticonvulsantPrescription only
AnticonvulsantPrescription only
Available as
LamictalTrileptal
  • Pill
  • Extended release
  • Chewable tablet
  • Dissolving tablet
  • Pill
  • Liquid
Used for (click to learn more)
LamictalTrileptal
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Lamictal (Lamotrigine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Trileptal (Oxcarbazepine)
Risk factors for serious side effects
LamictalTrileptal
  • History of depression
  • People also taking Depakote
  • Taking more than the prescribed dose
  • Increasing the dose too quickly
        • Taking birth control pills
        • Stopping Lamictal (Lamotrigine) suddenly
        Detailed Lamictal (Lamotrigine) risks & warnings »
        • Age 65 or older
        • dehydration
        • Taking diuretics (water pills)
        • Had allergic reaction to Tegretol (carbamazepine)
        • Asian ancestry
        • History of depression
        • Stopping Trileptal (Oxcarbazepine) suddenly
          • History of osteoporosis
          • History of fractures
            • Children
            Detailed Trileptal (Oxcarbazepine) risks & warnings »
            Pregnancy category
            LamictalTrileptal
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            • Take with food to avoid upset stomach.
            • Trileptal (Oxcarbazepine) can be taken with or without food.
            Kidneys and liver
            No specific kidneys and liver-related info.
            • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.
            • Can cause difficulty concentrating, tiredness or drowsiness, and problems with coordination.
            • You can experience dizziness, drowsiness, double vision, stomach upset, and trouble with coordination while on this.
            Weight
            No specific weight-related info.
            • Hypothyroidism (low thyroid levels) have been reported with Trileptal (Oxcarbazepine). Your thyroid levels may need to be tested regularly, Let your doctor know if you are more fatigued, gaining weight without any apparent reason, feeling more depressed, or are more sensitive to cold.
            Upsides and benefits
            LamictalTrileptal
            • Effective at lowering the frequency of seizures in people with epilepsy or Lennox-Gestaut syndrome. Typically used together with other medications for severe seizure disorders.
            • Works best for partial, tonic-clonic, and absence seizures.
            • A first-line treatment for bipolar disorder. Effective long-term treatment for stabilizing mood. Prevents both depressive and manic episodes, but the effect is greater for preventing depression.
            • Doesn't require routine blood tests.
            • Trileptal (Oxcarbazepine) is effective at lowering the frequency of seizures, especially for people with partial seizures.
            • If you have trouble swallowing tablets, Trileptal (Oxcarbazepine) is also available as an oral solution.
            • You won’t need to get regular blood tests to check the drug levels in your body.
            • Available in a generic form.
            Downsides and risks
            LamictalTrileptal
            • Can cause double vision, dizziness, sleepiness, and headache.
            • Has the risk of a rare but life-threatening rash.
            • Can make hormonal birth control less effective.
            • Might be less effective than other medicines for treating manic episodes (acute mania) in people with bipolar disorder.
            • It’s important to take your dose on time so that Trileptal (Oxcarbazepine) has steady levels in your body.
            • Interacts with many other medicines and supplements.
            • Can cause difficulty concentrating, tiredness or drowsiness, and problems with coordination.
            • If you have kidney problems, your dose may need to be adjusted. Your doctor will check your kidney function regularly.
            • Being pregnant lowers the levels of Trileptal (Oxcarbazepine), so the medicine might not be as effective at preventing seizures.
            Tips from our pharmacists for people taking the medication
            LamictalTrileptal
            • Follow dose adjustments set by your doctor to minimize skin rash.
            • Take with food to avoid upset stomach.
            • Report rash, blurry vision, fever, persistent headache, or neck stiffness to your doctor.
            • Makes hormonal birth control less effective.
            • Takes 4 to 6 weeks to feel full effects on mood.
            • You can experience dizziness, drowsiness, double vision, stomach upset, and trouble with coordination while on this.
            • If you start having skin rashes or thoughts of suicide, tell your doctor immediately.
            • If you need to stop taking Trileptal (Oxcarbazepine), do so over at least one week to prevent withdrawal seizures.
            • Trileptal (Oxcarbazepine) makes birth control and many other medicines less effective.
            • Trileptal (Oxcarbazepine) can be taken with or without food.
            • If you're taking the oral suspension, use the measuring device given with the medicine. Don’t use your household tablespoons to measure.
            Learn more
            More about LamictalSide effectsReviews & ratingsAlternativesFDA package insert
            More about TrileptalSide effectsReviews & ratingsAlternativesFDA package insert