Compare Lantus vs. Human insulin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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(Insulin Glargine)

(Human Insulin)

Lowers blood sugar. Lantus (Insulin Glargine) is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.
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Reviews & ratings
Button Group. All currently active
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Reviews for Lantus (Insulin Glargine)
of people say Lantus (Insulin Glargine) is worth it
say it works well
say it's a big hassle
Reviews for Humulin (Human Insulin)
Same vs. Lantus (Insulin Glargine)
5% vs. Lantus (Insulin Glargine)
+3% vs. Lantus (Insulin Glargine)
Side effects

The Lantus FDA package insert doesn’t have numbers about how common side effects are.

More about Lantus side effects »

The Human insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human insulin side effects »
How it works
Lantus (Insulin Glargine) is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.
Type of medication
Prescription only
Prescription only
Available as
  • Injection
  • Injection
  • Inhaler
Used for (click to learn more)
Participate in a study
At least one of these drugs has an active study on Type 2 Diabetes you can participate in
Do good & earn up to $60
If your A1c is higher than 7.5% and you have an iPhone, you can join an online study today.
Risk factors for serious side effects
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
  • Use of other medicine that lowers potassium
  • Current electrolyte imbalance
    Detailed Lantus (Insulin Glargine) risks & warnings »
          Detailed Humulin (Human Insulin) risks & warnings »
          Pregnancy category
          No specific alcohol-related info.No specific alcohol-related info.
          No specific food-related info.No specific food-related info.
          Kidneys and liver
          • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
          No specific kidneys and liver-related info.
          No specific sex-related info.No specific sex-related info.
          No specific sleep-related info.No specific sleep-related info.
          • Likely to cause moderate weight gain (around 4 to 6 pounds).
          • Can cause weight gain and low blood sugar.
          • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
          Upsides and benefits
          • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
          • Lantus is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
          • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
          • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
          • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
          • Some types of this medication are available without a prescription.
          • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
          • Available in different combinations so that you can do one shot or multiple shots a day.
          Downsides and risks
          • You have to take insulin by injection.
          • You have to check your blood sugar every day.
          • Likely to cause moderate weight gain (around 4 to 6 pounds).
          • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
          • Has to be taken exactly as directed or it can cause high or low blood sugar.
          • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
          Tips from our pharmacists for people taking the medication
          • Long-acting insulin good for baseline blood sugar control.
          • Works in 1 hour and lasts about 24 hours.
          • Can cause weight gain and low blood sugar.
          • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
          • Always have a good source of sugar nearby for low blood sugar episodes.
          • Take it at the same time every day.
          • Make sure you understand how to give yourself the injections.
          • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
          • Check your blood sugar levels every day.
          • Change the location where you give yourself the shot every time.
          • Don't use if the liquid in the vial looks different than normal.
          • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
          • Take the medication exactly how your doctor tells you to.
          • Know the symptoms of low blood sugar.
          Learn more
          More about LantusSide effectsReviews & ratingsAlternativesFDA package insert
          More about Human insulinSide effectsReviews & ratingsAlternativesFDA package insert