Compare Lantus vs. Human Insulin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lantus
(insulin glargine)

Humulin
(human insulin)

Lowers blood sugar. Lantus (Insulin Glargine) is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.08Lantus
Reviews for Lantus (insulin glargine)
67%
of people (All ages) say Lantus (insulin glargine) is worth it
51%
say it works well
14%
say it's a big hassle
584 reviews
Have you used Lantus (insulin glargine)?
Worth itNot sureNot worth it
Reviews for Humulin (human insulin)
67%
Same vs. Lantus (insulin glargine)
46%
-5% worse vs. Lantus (insulin glargine)
11%
+3% better vs. Lantus (insulin glargine)
Have you used Humulin (human insulin)?
Worth itNot sureNot worth it
Side effects
LantusHuman Insulin
  • Ear, nose, or throat infection 22%
  • Infection 9%
  • Accidental injury 6%
  • Headache 6%
  • Ankle and leg swelling 20%
  • High blood pressure 20%
  • Sinus inflammation 19%
  • Flu 19%
  • Clouded eye lens 18%
  • Bronchitis 15%
More Lantus side effects »

The Human Insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human Insulin side effects »
How it works
LantusHuman Insulin
Lantus (Insulin Glargine) is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.
Type of medication
LantusHuman Insulin
Prescription only
Prescription only
Available as
LantusHuman Insulin
  • Injection
  • Injection
  • Inhaler
Used for
LantusHuman Insulin
Risk factors for serious side effects
LantusHuman Insulin
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
  • Use of other medicine that lowers potassium
  • Current electrolyte imbalance
    Detailed Lantus (insulin glargine) risks & warnings »
          Detailed Humulin (human insulin) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Kidneys and liver
          LantusHuman Insulin
          • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
          No kidneys and liver related info.
          Weight
          LantusHuman Insulin
          • Likely to cause moderate weight gain (around 4 to 6 pounds).
          • Can cause weight gain and low blood sugar.
          • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
          Upsides and benefits
          LantusHuman Insulin
          • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
          • Lantus is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
          • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
          • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
          • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
          • Some types of this medication are available without a prescription.
          • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
          • Available in different combinations so that you can do one shot or multiple shots a day.
          Downsides and risks
          LantusHuman Insulin
          • You have to take insulin by injection.
          • You have to check your blood sugar every day.
          • Likely to cause moderate weight gain (around 4 to 6 pounds).
          • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
          • Has to be taken exactly as directed or it can cause high or low blood sugar.
          • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
          Tips from our pharmacists for people taking the medication
          LantusHuman Insulin
          • Long-acting insulin good for baseline blood sugar control.
          • Works in 1 hour and lasts about 24 hours.
          • Can cause weight gain and low blood sugar.
          • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
          • Always have a good source of sugar nearby for low blood sugar episodes.
          • Take it at the same time every day.
          • Make sure you understand how to give yourself the injections.
          • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
          • Check your blood sugar levels every day.
          • Change the location where you give yourself the shot every time.
          • Don't use if the liquid in the vial looks different than normal.
          • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
          • Take the medication exactly how your doctor tells you to.
          • Know the symptoms of low blood sugar.
          Learn more
          More about LantusSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Lantus (insulin glargine)?
          Worth itNot sureNot worth it
          More about Human InsulinSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Humulin (human insulin)?
          Worth itNot sureNot worth it