Compare Lantus vs. Januvia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lantus
(Insulin Glargine)

Januvia
(Sitagliptin)

Lowers blood sugar. Lantus (Insulin Glargine) is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Januvia (Sitagliptin) is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.086058519793459Lantus
Reviews for Lantus (Insulin Glargine)
67%
of people say Lantus (Insulin Glargine) is worth it
51%
say it works well
14%
say it's a big hassle
Reviews for Januvia (Sitagliptin)
43%
24% vs. Lantus (Insulin Glargine)
34%
17% vs. Lantus (Insulin Glargine)
17%
3% vs. Lantus (Insulin Glargine)
Side effects
LantusJanuvia

The Lantus FDA package insert doesn’t have numbers about how common side effects are.

More about Lantus side effects »
  • Common cold 2%
  • Diarrhea 1%
More Januvia side effects »
How it works
LantusJanuvia
Lantus (Insulin Glargine) is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.Januvia (Sitagliptin) is an anti-diabetic drug. It helps your body release more insulin in order to lower blood sugar.
Type of medication
LantusJanuvia
Anti-diabetic
Insulin
Prescription only
Anti-diabetic
DPP-4 inhibitor
Prescription only
Available as
LantusJanuvia
  • Injection
  • Pill
Used for (click to learn more)
LantusJanuvia
Risk factors for serious side effects
LantusJanuvia
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
  • Use of other medicine that lowers potassium
  • Current electrolyte imbalance
    Detailed Lantus (Insulin Glargine) risks & warnings »
        Detailed Januvia (Sitagliptin) risks & warnings »
        Pregnancy category
        LantusJanuvia
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
        No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        • Likely to cause moderate weight gain (around 4 to 6 pounds).
        • Can cause weight gain and low blood sugar.
        • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
        Upsides and benefits
        LantusJanuvia
        • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
        • Lantus is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
        • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
        • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
        • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
        • Oral blood sugar-lowering medicine.
        • Lowers A1c levels by 0.5-0.8%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • Uses the hormones naturally produced by your body to affect how sugar is processed.
        • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
        • You don't have to check your blood sugar every day with this medicine.
        Downsides and risks
        LantusJanuvia
        • You have to take insulin by injection.
        • You have to check your blood sugar every day.
        • Likely to cause moderate weight gain (around 4 to 6 pounds).
        • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
        • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
        • Likely expensive since there's no generic version available.
        • Some people might get frequent throat infections or nasal congestion.
        Tips from our pharmacists for people taking the medication
        LantusJanuvia
        • Long-acting insulin good for baseline blood sugar control.
        • Works in 1 hour and lasts about 24 hours.
        • Can cause weight gain and low blood sugar.
        • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
        • Always have a good source of sugar nearby for low blood sugar episodes.
        • Take it at the same time every day.
        • Make sure you understand how to give yourself the injections.
        • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
        • Check your blood sugar levels every day.
        • Can cause headache and cold-like symptoms.
        • Tell your doctor about persistent stomach pain, nausea, vomiting, or loss of appetite.
        • Can be expensive depending on insurance coverage.
        • Check your blood sugar regularly.
        Learn more
        More about LantusSide effectsReviews & ratingsAlternativesFDA package insert
        More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert