Compare Lantus vs. Novolog

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lantus
(Insulin Glargine)

Novolog
(Insulin Aspart)

Lowers blood sugar. Lantus (Insulin Glargine) is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Novolog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.08Lantus
Reviews for Lantus
67%
of people (All ages) say Lantus is worth it
51%
say it works well
14%
say it's a big hassle
584 reviews
Have you used Lantus (Insulin Glargine)?
Worth itNot sureNot worth it
Reviews for Novolog
58%
+9% better vs. Lantus
46%
+5% better vs. Lantus
19%
+5% better vs. Lantus
177 reviews
Have you used Novolog (Insulin Aspart)?
Worth itNot sureNot worth it
Side effects
LantusNovolog
  • Accidental injury 6%
  • Headache 6%
  • Infection 9%
  • Upper respiratory tract infection 22%
  • Retinal vascular disorder 6%
  • Urinary tract infection 11%
  • Diarrhea 11%
  • Depression 11%
  • Cough 12%
  • Pain in extremity 13%
More Lantus side effects »
  • Chest pain 5%
  • Headache 5%
  • Skin disorder 5%
  • Abdominal pain 5%
  • Sinusitis 5%
  • Urinary tract infection 8%
  • Sensory disturbance 9%
  • Onychomycosis 10%
  • Hyporeflexia 11%
  • Diarrhea 5%
More Novolog side effects »
How it works
LantusNovolog
Lantus (Insulin Glargine) is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.Novolog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.
Type of medication
LantusNovolog
Prescription onlyNo lower cost generic availablePrescription onlyNo lower cost generic available
Available as
LantusNovolog
  • Injection
  • Injection
Used for
LantusNovolog
Risk factors for serious side effects
LantusNovolog
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Lantus (Insulin Glargine) risks & warnings »
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Novolog (Insulin Aspart) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
LantusNovolog
No food related info.
  • Short-acting insulin good for blood sugar control around meal times.
  • Novolog is a fast-acting insulin that provides sugar control after meals.
Kidneys and liver
LantusNovolog
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Weight
LantusNovolog
  • Can cause weight gain and low blood sugar.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Can cause weight gain and low blood sugar.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
Upsides and benefits
LantusNovolog
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Lantus is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Novolog is a fast-acting insulin that provides sugar control after meals.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Downsides and risks
LantusNovolog
  • You have to take insulin by injection.
  • You have to check your blood sugar every day.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
  • You have to take insulin by injection.
  • You have to check your blood sugar multiple times every day, usually before each meal.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
Tips from our pharmacists for people taking the medication
LantusNovolog
  • Long-acting insulin good for baseline blood sugar control.
  • Works in 1 hour and lasts about 24 hours.
  • Can cause weight gain and low blood sugar.
  • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
  • Always have a good source of sugar nearby for low blood sugar episodes.
  • Take it at the same time every day.
  • Make sure you understand how to give yourself the injections.
  • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
  • Check your blood sugar levels every day.
  • Short-acting insulin good for blood sugar control around meal times.
  • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
  • Can cause weight gain and low blood sugar.
  • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
  • Always have a good source of sugar nearby for low blood sugar episodes.
  • Make sure you understand how to give yourself the injections.
  • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
  • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
  • Check your blood sugar levels every day.
Learn more
More about LantusSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lantus (Insulin Glargine)?
Worth itNot sureNot worth it
More about NovologSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Novolog (Insulin Aspart)?
Worth itNot sureNot worth it