Compare Latuda vs. Invega

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Latuda
(Lurasidone)

Invega
(Paliperidone)

Helps control your thoughts and mood. Latuda (Lurasidone) is good for treating schizophrenia and depression related to bipolar disorder. It's less likely to cause weight gain, cholesterol, blood sugar, and heart rhythm problems.Helps control your thoughts and mood. Invega (Paliperidone) is good for treating psychosis and improving mood. It's more likely to cause hormone problems than other antipsychotics.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.116279069767442Latuda
Reviews for Latuda (Lurasidone)
60%
of people say Latuda (Lurasidone) is worth it
60%
say it works well
21%
say it's a big hassle
Reviews for Invega (Paliperidone)
30%
30% vs. Latuda (Lurasidone)
33%
27% vs. Latuda (Lurasidone)
30%
9% vs. Latuda (Lurasidone)
Side effects
LatudaInvega
  • Restlessness 19%
  • Drowsiness 16%
  • Parkinsonism 12%
  • Muscle twitching 6%
  • Nausea 6%
  • Any side effect 3%
  • Agitation 3%
  • Anxiety 3%
  • Indigestion 2%
  • Dizziness 2%
More Latuda side effects »
  • Abnormally fast heart beat 7%
  • Anxiety 5%
  • Common cold 4%
  • Indigestion 4%
  • Constipation 3%
  • Positional low blood pressure 3%
  • Muscle weakness 3%
  • Headache 2%
  • Nausea 2%
  • Abdominal discomfort 2%
More Invega side effects »
How it works
LatudaInvega
Latuda (Lurasidone) is a second generation antipsychotic. It treats schizophrenia and bipolar depression by adjusting the levels of dopamine and serotonin in your brain, which affects thoughts and mood.Invega (Paliperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affect your thoughts and mood.
Type of medication
LatudaInvega
Antipsychotic
2nd generation
Prescription only
Antipsychotic
Atypical
Prescription only
Available as
LatudaInvega
  • Pill
  • Extended release
  • Injection
Used for (click to learn more)
LatudaInvega
Risk factors for serious side effects
LatudaInvega
  • Elderly patients with dementia
  • Age 18 years or younger
    • Duration of treatment
    • Taking with alcohol
    • Taking other medicines that make you less alert
      • History of diabetes
      • History of high cholesterol
      Detailed Latuda (Lurasidone) risks & warnings »
      • Elderly patients with dementia
          • History of heart problems
          • Drug interactions
            • People with diabetes
            • People with high cholesterol
            • People with diabetes
            • Alcohol
            • Taking other medicines that make you less alert
              Detailed Invega (Paliperidone) risks & warnings »
              Pregnancy category
              LatudaInvega
              BFDA pregnancy category (Probably safe)

              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

              See the FDA package insert
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              Alcohol
              • Need to avoid drinking alcohol while taking Latuda (Lurasidone).
              No specific alcohol-related info.
              Food
              • Take it once a day at the same time each day. It works faster when you take it with a small snack (at least 350 calories).
              • Latuda (Lurasidone) can increase your blood sugar and cholesterol. However, Latuda (Lurasidone) is the least likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              • Invega (Paliperidone) can increase your blood sugar and cholesterol. Invega (Paliperidone) is moderately likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              Kidneys and liver
              No specific kidneys and liver-related info.No specific kidneys and liver-related info.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.
              • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
              Weight
              • Compared to other antipsychotics, it has a lower risk of causing weight gain and changes to cholesterol, blood sugar, and heart rhythm.
              • Sometimes causes weight gain and low blood pressure.
              • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              Upsides and benefits
              LatudaInvega
              • Has been shown in clinical studies to help people felt better and experience improvements with their thoughts and mood.
              • It’s a newer type of medication and works differently than traditional antidepressants.
              • Can be taken alone or with other medications that manage your mood.
              • Compared to other antipsychotics, it has a lower risk of causing weight gain and changes to cholesterol, blood sugar, and heart rhythm.
              • Effective at relieving psychotic symptoms and relapse rates for people with schizophrenia.
              • Also relieves psychotic symptoms and improves mood for people with schizoaffective disorder.
              • Works just as well as other antipsychotic medicines.
              • Less likely to cause heart or liver problems than some other antipsychotic medications.
              Downsides and risks
              LatudaInvega
              • Certain antifungal and heart medicines can increase the amount of Latuda (Lurasidone) in your body and put you at risk for more side effects. Ask your doctor or pharmacist about any drug interactions between medicines you’re taking.
              • Can cause you to be more sensitive to heat and make it harder for your body to cool off.
              • Need to avoid drinking alcohol while taking Latuda (Lurasidone).
              • Elderly people who have dementia shouldn't take Latuda (Lurasidone).
              • Invega (Paliperidone) has a high risk of causing hormone problems that cause nipples to leak fluid and male breasts to grow abnormally large.
              • Sometimes causes weight gain and low blood pressure.
              • Mild risk of causing extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
              • You might need routine blood tests to check how the medicine is affecting your body.
              • Not a good choice for elderly people who have dementia.
              • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
              Tips from our pharmacists for people taking the medication
              LatudaInvega
              • Take it once a day at the same time each day. It works faster when you take it with a small snack (at least 350 calories).
              • Don’t eat grapefruit or drink grapefruit juice while taking Latuda (Lurasidone). It can negatively affect how Latuda (Lurasidone) works.
              • Can cause dizziness and nausea, so avoid activities that require you to be alert until you get used to it.
              • Usually takes 4 to 6 weeks to see the full effects on your thoughts and mood, so hang in there until you find the right dose that works for you.
              • It'll take 4 to 6 weeks to see the medication's full effects on thoughts and mood.
              • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
              • For the first week, avoid activities like driving that require you to be alert.
              • Don't worry if you see tablet shells in your stool since the medication was already absorbed by your body.
              • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
              • Elderly people who have dementia shouldn't take Invega (Paliperidone).
              Learn more
              More about LatudaSide effectsReviews & ratingsAlternativesFDA package insert
              More about InvegaSide effectsReviews & ratingsAlternativesFDA package insert