Compare Latuda vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Latuda (Lurasidone)

Prescription only

Saphris (asenapine)

Prescription only
Helps control your thoughts and mood.

Latuda (Lurasidone) is good for treating schizophrenia and depression related to bipolar disorder. It's less likely to cause weight gain, cholesterol, blood sugar, and heart rhythm problems.

3.8/ 5 average rating with 61 reviewsforLatuda
Treats bipolar disorder and schizophrenia.

While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.

Upsides
  • Has been shown in clinical studies to help people felt better and experience improvements with their thoughts and mood.
  • It’s a newer type of medication and works differently than traditional antidepressants.
  • Can be taken alone or with other medications that manage your mood.
  • Compared to other antipsychotics, it has a lower risk of causing weight gain and changes to cholesterol, blood sugar, and heart rhythm.
  • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
  • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
  • Compared to other medicines, the side effects of Saphris (asenapine) are milder.
Downsides
  • Certain antifungal and heart medicines can increase the amount of Latuda (Lurasidone) in your body and put you at risk for more side effects. Ask your doctor or pharmacist about any drug interactions between medicines you’re taking.
  • Can cause you to be more sensitive to heat and make it harder for your body to cool off.
  • Need to avoid drinking alcohol while taking Latuda (Lurasidone).
  • Elderly people who have dementia shouldn't take Latuda (Lurasidone).
  • Saphris (asenapine) is only available as a brand name.
  • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
  • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
Used for
Dosage forms
  • Pill
  • Dissolving pill
Price
Lowest price
$1055.00
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Reviews
61 reviews so far
61%
saidit'sworth it
61%
saiditworked well
25%
saidit'sa big hassle

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Side effects
16possible side effects
  • Somnolence
    22%
  • Akathisia
    15%
  • Nausea
    12%
  • Parkinsonism
    11%
  • Any side effect
    9%
  • Vomiting
    8%
  • Dyspepsia
    8%
  • Insomnia
    8%
  • Agitation
    6%
  • Anxiety
    6%
  • Dystonia
    5%
  • Dizziness
    5%
  • Fatigue
    4%
  • Back Pain
    4%
  • Restlessness
    3%
  • Salivary hypersecretion
    2%
See more detailed side effects
10possible side effects
  • Sleepiness
    22%
  • Trouble sleeping
    10%
  • Difficulty controlling movements
    6%
  • Numbness in the mouth
    5%
  • Fatigue
    4%
  • Dizziness
    4%
  • Indigestion
    3%
  • Swelling in the arms and legs
    3%
  • Weight gain
    3%
  • High blood pressure
    3%
See more detailed side effects
Risks and risk factors
  • Increased risk of death
    • Elderly patients with dementia
  • Suicidal thoughts or behavior
    • Age 18 years or younger
  • Neuroleptic malignant syndrome (NMS)
  • Abnormal and involuntary muscle movements
    • Duration of treatment
  • Sedation and driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Blood disorders
  • Higher blood sugar and cholesterol
    • History of diabetes
    • History of high cholesterol
See more detailed risks and warnings
  • Higher risk of death
    • People age 65 or older with dementia and psychosis
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Difficulty controlling movements
  • Weight gain and diabetes
  • Changes in blood pressure and fainting
    • High blood pressure
    • History of heart disease
  • Higher risk of infection
See more detailed risks and warnings