Compare Latuda vs. Zyprexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Latuda
(lurasidone)

Zyprexa
(olanzapine)

Helps control your thoughts and mood. Latuda (Lurasidone) is good for treating schizophrenia and depression related to bipolar disorder. It's less likely to cause weight gain, cholesterol, blood sugar, and heart rhythm problems.Helps control your thoughts and mood. Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it's more likely to cause weight gain and sleepiness than other antipsychotics.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.15Latuda
Reviews for Latuda
61%
of people (All ages) say Latuda is worth it
61%
say it works well
25%
say it's a big hassle
Have you used Latuda (lurasidone)?
Worth itNot sureNot worth it
Reviews for Zyprexa
41%
+20% better vs. Latuda
51%
+10% better vs. Latuda
51%
+26% better vs. Latuda
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it
Side effects
LatudaZyprexa
  • Drowsiness 12%
  • Restlessness 12%
  • Nausea 6%
  • Parkinsonism 6%
  • Any side effect 3%
  • Indigestion 2%
  • Vomiting 2%
  • Sleep difficulty 1%
  • Anxiety 3%
  • Agitation 3%
More Latuda side effects »
  • Dizziness 7%
  • Constipation 6%
  • Personality disorder 4%
  • Weight gain 5%
  • Feeling dizzy/faint when standing up 3%
  • Akathisia (can't sit still) 4%
  • Drowsiness 22%
  • Dry mouth 15%
  • Weakness 9%
  • Stomach problems 6%
More Zyprexa side effects »
How it works
LatudaZyprexa
Latuda (Lurasidone) is a second generation antipsychotic. It treats schizophrenia and bipolar depression by adjusting the levels of dopamine and serotonin in your brain, which affects thoughts and mood.Zyprexa (olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change chemical activity (like dopamine and serotonin) in your brain, which affects thoughts and mood.
Type of medication
LatudaZyprexa
Prescription onlyPrescription only
Available as
LatudaZyprexa
  • Pill
  • Pill
  • Dissolving tablet
  • Injection
Used for
LatudaZyprexa
Risk factors for serious side effects
LatudaZyprexa
  • Elderly patients with dementia
  • Age 18 years or younger
  • Duration of treatment
  • Taking with alcohol
  • Taking other medicines that make you less alert
Detailed Latuda (lurasidone) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Zyprexa (olanzapine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
LatudaZyprexa
  • Need to avoid drinking alcohol while taking Latuda (Lurasidone).
No alcohol related info.
Food
LatudaZyprexa
  • Latuda (Lurasidone) can increase your blood sugar and cholesterol. However, Latuda (Lurasidone) is the least likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No food related info.
Sleep
LatudaZyprexa
No sleep related info.
  • Can cause dizziness and drowsiness.
  • Might make you more sleepy than some antipsychotics.
Weight
LatudaZyprexa
No weight related info.
  • Zyprexa (olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Zyprexa (olanzapine) can also cause you to gain weight. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and increased cholesterol or blood sugar.
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
Upsides and benefits
LatudaZyprexa
  • Has been shown in clinical studies to help people felt better and experience improvements with their thoughts and mood.
  • It’s a newer type of medication and works differently than traditional antidepressants.
  • Can be taken alone or with other medications that manage your mood.
  • Compared to other antipsychotics, it has a lower risk of causing weight gain and changes to cholesterol, blood sugar, and heart rhythm.
  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
  • Less likely to cause heart problems than other antipsychotics.
  • Less likely to cause movement problems compared to older antipsychotics.
Downsides and risks
LatudaZyprexa
  • Certain antifungal and heart medicines can increase the amount of Latuda (Lurasidone) in your body and put you at risk for more side effects. Ask your doctor or pharmacist about any drug interactions between medicines you’re taking.
  • Can cause you to be more sensitive to heat and make it harder for your body to cool off.
  • Need to avoid drinking alcohol while taking Latuda (Lurasidone).
  • Elderly people who have dementia shouldn't take Latuda (Lurasidone).
  • More likely to cause weight gain and increase cholesterol or blood sugar compared to other antipsychotics.
  • Might make you more sleepy than some antipsychotics.
  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive movements you can't control.
  • You may need routine blood tests to check how the medicine is affecting your body..
Tips from our pharmacists for people taking the medication
LatudaZyprexa
  • Take it once a day at the same time each day. It works faster when you take it with a small snack (at least 350 calories).
  • Don’t eat grapefruit or drink grapefruit juice while taking Latuda (Lurasidone). It can negatively affect how Latuda (Lurasidone) works.
  • Can cause dizziness and nausea, so avoid activities that require you to be alert until you get used to it.
  • Usually takes 4 to 6 weeks to see the full effects on your thoughts and mood, so hang in there until you find the right dose that works for you.
  • Takes at least 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and increased cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take Zyprexa (olanzapine).
Learn more
More about LatudaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Latuda (lurasidone)?
Worth itNot sureNot worth it
More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zyprexa (olanzapine)?
Worth itNot sureNot worth it