Compare Latuda vs. Zyprexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Latuda
(Lurasidone)

Zyprexa
(Olanzapine)

Helps control your thoughts and mood. Latuda (Lurasidone) is good for treating schizophrenia and depression related to bipolar disorder. It's less likely to cause weight gain, cholesterol, blood sugar, and heart rhythm problems.Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.116279069767442Latuda
Reviews for Latuda (Lurasidone)
60%
of people say Latuda (Lurasidone) is worth it
60%
say it works well
21%
say it's a big hassle
Reviews for Zyprexa (Olanzapine)
45%
15% vs. Latuda (Lurasidone)
53%
7% vs. Latuda (Lurasidone)
47%
26% vs. Latuda (Lurasidone)
Side effects
LatudaZyprexa
  • Restlessness 19%
  • Drowsiness 16%
  • Parkinsonism 12%
  • Muscle twitching 6%
  • Nausea 6%
  • Any side effect 3%
  • Agitation 3%
  • Anxiety 3%
  • Indigestion 2%
  • Dizziness 2%
More Latuda side effects »
  • Relaxation or sleepiness 39%
  • Increased appetite 25%
  • Weight increase 22%
  • Drowsiness 22%
  • Dry mouth 15%
  • Dizziness 12%
  • Muscle weakness 9%
  • Fatigue 8%
  • Constipation 6%
  • Indigestion 6%
More Zyprexa side effects »
How it works
LatudaZyprexa
Latuda (Lurasidone) is a second generation antipsychotic. It treats schizophrenia and bipolar depression by adjusting the levels of dopamine and serotonin in your brain, which affects thoughts and mood.Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
LatudaZyprexa
Antipsychotic
2nd generation
Prescription only
Antipsychotic
Atypical
Prescription only
Available as
LatudaZyprexa
  • Pill
  • Pill
  • Dissolving tablet
  • Injection
Used for (click to learn more)
LatudaZyprexa
Risk factors for serious side effects
LatudaZyprexa
  • Elderly patients with dementia
  • Age 18 years or younger
    • Duration of treatment
    • Taking with alcohol
    • Taking other medicines that make you less alert
      • History of diabetes
      • History of high cholesterol
      Detailed Latuda (Lurasidone) risks & warnings »
      • Elderly patients with dementia
          • History of heart problems
          • Drug interactions
            • People with diabetes
            • People with high cholesterol
            • People with diabetes
            • Alcohol
            • Taking other medicines that make you less alert
              Detailed Zyprexa (Olanzapine) risks & warnings »
              Pregnancy category
              LatudaZyprexa
              Alcohol
              • Need to avoid drinking alcohol while taking Latuda (Lurasidone).
              No specific alcohol-related info.
              Food
              • Take it once a day at the same time each day. It works faster when you take it with a small snack (at least 350 calories).
              • Latuda (Lurasidone) can increase your blood sugar and cholesterol. However, Latuda (Lurasidone) is the least likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              • Zyprexa (Olanzapine) can increase your blood sugar and cholesterol. Zyprexa (Olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              Kidneys and liver
              No specific kidneys and liver-related info.No specific kidneys and liver-related info.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.
              • Can cause dizziness and drowsiness.
              Weight
              • Compared to other antipsychotics, it has a lower risk of causing weight gain and changes to cholesterol, blood sugar, and heart rhythm.
              • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
              • May cause weight gain and worsen cholesterol or blood sugar.
              • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
              Upsides and benefits
              LatudaZyprexa
              • Has been shown in clinical studies to help people felt better and experience improvements with their thoughts and mood.
              • It’s a newer type of medication and works differently than traditional antidepressants.
              • Can be taken alone or with other medications that manage your mood.
              • Compared to other antipsychotics, it has a lower risk of causing weight gain and changes to cholesterol, blood sugar, and heart rhythm.
              • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
              • Lowers relapse rates for schizophrenia and bipolar disorder.
              • Antipsychotic medicines are all about equally effective.
              • Less likely to cause heart problems than some antipsychotics.
              Downsides and risks
              LatudaZyprexa
              • Certain antifungal and heart medicines can increase the amount of Latuda (Lurasidone) in your body and put you at risk for more side effects. Ask your doctor or pharmacist about any drug interactions between medicines you’re taking.
              • Can cause you to be more sensitive to heat and make it harder for your body to cool off.
              • Need to avoid drinking alcohol while taking Latuda (Lurasidone).
              • Elderly people who have dementia shouldn't take Latuda (Lurasidone).
              • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
              • Might make you more sleepy than some antipsychotics.
              • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
              • You might need routine blood tests to check how the medicine is affecting your body.
              • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
              Tips from our pharmacists for people taking the medication
              LatudaZyprexa
              • Take it once a day at the same time each day. It works faster when you take it with a small snack (at least 350 calories).
              • Don’t eat grapefruit or drink grapefruit juice while taking Latuda (Lurasidone). It can negatively affect how Latuda (Lurasidone) works.
              • Can cause dizziness and nausea, so avoid activities that require you to be alert until you get used to it.
              • Usually takes 4 to 6 weeks to see the full effects on your thoughts and mood, so hang in there until you find the right dose that works for you.
              • Takes 4 to 6 weeks to see full effects on thoughts and mood.
              • Can cause dizziness and drowsiness.
              • For the first week, avoid activities that require you to be alert.
              • May cause weight gain and worsen cholesterol or blood sugar.
              • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
              • Elderly people with dementia shouldn't take it.
              Learn more
              More about LatudaSide effectsReviews & ratingsAlternativesFDA package insert
              More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert