Compare Levaquin vs. Bactrim

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Levaquin
(Levofloxacin)

Bactrim
(Sulfamethoxazole / Trimethoprim)

Kills bacteria. Levaquin (Levofloxacin) is good for treating many bacterial infections and is available as generic. However, it can cause damage to your tendons, and make your skin more sensitive to the sun.Kills bacteria. Bactrim (Sulfamethoxazole / Trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn. Also, it can cause birth defects, so talk to your doctor if you're pregnant.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.41Levaquin
Reviews for Levaquin (Levofloxacin)
53%
of people (All ages) say Levaquin (Levofloxacin) is worth it
40%
say it works well
31%
say it's a big hassle
Have you used Levaquin (Levofloxacin)?
Worth itNot sureNot worth it
Reviews for Bactrim (Sulfamethoxazole / Trimethoprim)
59%
+6% vs. Levaquin (Levofloxacin)
49%
+9% vs. Levaquin (Levofloxacin)
22%
+9% vs. Levaquin (Levofloxacin)
473 reviews
Have you used Bactrim (Sulfamethoxazole / Trimethoprim)?
Worth itNot sureNot worth it
Side effects
LevaquinBactrim

The Levaquin FDA package insert doesn’t have numbers about how common side effects are.

More about Levaquin side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »
How it works
LevaquinBactrim
Levaquin (Levofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Bactrim (Sulfamethoxazole / Trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria by preventing them from making proteins and other chemicals that keep them alive.
Type of medication
LevaquinBactrim
Antibiotic
Fluoroquinolone
Prescription only
Antibiotic
Sulfonamide
Prescription only
Available as
LevaquinBactrim
  • Pill
  • Liquid
  • Pill
  • Liquid
Used for (click to learn more)
LevaquinBactrim
Risk factors for serious side effects
LevaquinBactrim
  • Over 60 years of age
  • On long-term steroid use
  • Heart, kidney, or lung transplant
  • History of liver disease
  • Seizures
Detailed risks & warnings »
    Detailed risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Kidneys and liver
    LevaquinBactrim
    • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
    No kidneys and liver related info.
    Pain
    LevaquinBactrim
    • If you notice pain in your Achilles tendons, contact your doctor.
    • If you notice redness/inflammation, pain or swelling in your joints or muscles, especially in the Achilles tendon, contact your doctor immediately.
    • Talk to your doctor immediately if you start to feel burning, tingling, numbness, pain or you can't tolerate heat or cold. This could be a sign of nerve damage. It can happen as soon as you start taking the medication and may not go away if you stop it.
    No pain related info.
    Upsides and benefits
    LevaquinBactrim
    • Available in different forms: tablet, capsule, and suspension.
    • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
    • Available in generic.
    • Used to treat many types of bacterial infections.
    • Available in different forms: tablet, capsule and suspension.
    • Less resistance seen to this antibiotic. Your doctor may run tests to see if Bactrim responds to your infection.
    • Available in generic.
    • Used to treat many types of bacterial infections.
    Downsides and risks
    LevaquinBactrim
    • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
    • Levofloxacin can make your skin more sensitive to the sun.
    • Can't be used if you've ever had myasthenia gravis.
    • You have to space out any medications with aluminum, magnesium or zinc by at least 2 hours.
    • Can cause changes in taste, headaches, and insomnia.
    • Makes your skin more sensitive to the sun.
    • Has to be taken with plenty of liquids.
    • May cause birth defects.
    • Can cause diarrhea.
    Tips from our pharmacists for people taking the medication
    LevaquinBactrim
    • If you notice pain in your Achilles tendons, contact your doctor.
    • Wear sunscreen if you're going to be out in the sun.
    • Take the medication exactly how the doctor tells you to.
    • Take this medication with plenty of fluids.
    • Space out any medications containing aluminum, magnesium or zinc by at least 2 hours.
    • Can cause changes in taste, headaches and insomnia.
    • Can cause diarrhea, nausea or vomiting.
    • Take this medication exactly how your doctor tells you to.
    • Can make your skin more sensitive to the sun.
    • Drink plenty of liquids when taking the medication.
    • Can cause rash.
    • Can cause diarrhea, nausea or vomiting.
    Learn more
    More about LevaquinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Levaquin (Levofloxacin)?
    Worth itNot sureNot worth it
    More about BactrimSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Bactrim (Sulfamethoxazole / Trimethoprim)?
    Worth itNot sureNot worth it