Compare Levaquin vs. Bactrim

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Levaquin
(Levofloxacin)

Bactrim
(Sulfamethoxazole / Trimethoprim)

Kills bacteria. Levaquin (Levofloxacin) is good for treating many bacterial infections and is available as generic. However, it can cause damage to your tendons, and make your skin more sensitive to the sun.Kills bacteria. Bactrim (Sulfamethoxazole / Trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn. Also, it can cause birth defects, so talk to your doctor if you're pregnant.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.364705882352941Levaquin
Reviews for Levaquin (Levofloxacin)
54%
of people say Levaquin (Levofloxacin) is worth it
39%
say it works well
29%
say it's a big hassle
Reviews for Bactrim (Sulfamethoxazole / Trimethoprim)
59%
+5% vs. Levaquin (Levofloxacin)
50%
+11% vs. Levaquin (Levofloxacin)
22%
+7% vs. Levaquin (Levofloxacin)
Side effects
LevaquinBactrim

The Levaquin FDA package insert doesn’t have numbers about how common side effects are.

More about Levaquin side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »
How it works
LevaquinBactrim
Levaquin (Levofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.Bactrim (Sulfamethoxazole / Trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria by preventing them from making proteins and other chemicals that keep them alive.
Type of medication
LevaquinBactrim
Antibiotic
Fluoroquinolone
Prescription only
Antibiotic
Sulfonamide
Prescription only
Available as
LevaquinBactrim
  • Pill
  • Liquid
  • Pill
  • Liquid
Used for (click to learn more)
LevaquinBactrim
Risk factors for serious side effects
LevaquinBactrim
  • Over 60 years of age
  • On long-term steroid use
  • Heart, kidney, or lung transplant
    • History of liver disease
    • Seizures
        • Diabetes
        • Taking medications for diabetes
            Detailed Levaquin (Levofloxacin) risks & warnings »
                    Detailed Bactrim (Sulfamethoxazole / Trimethoprim) risks & warnings »
                    Pregnancy category
                    LevaquinBactrim
                    CFDA pregnancy category (Weigh risks vs. benefits)

                    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                    See the FDA package insert
                    DFDA pregnancy category (Weigh risks vs. benefits)

                    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                    See the FDA package insert
                    Alcohol
                    No specific alcohol-related info.No specific alcohol-related info.
                    Food
                    No specific food-related info.No specific food-related info.
                    Kidneys and liver
                    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                    Sex
                    No specific sex-related info.No specific sex-related info.
                    Sleep
                    No specific sleep-related info.No specific sleep-related info.
                    Weight
                    No specific weight-related info.No specific weight-related info.
                    Upsides and benefits
                    LevaquinBactrim
                    • Available in different forms: tablet, capsule, and suspension.
                    • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
                    • Available in generic.
                    • Used to treat many types of bacterial infections.
                    • Available in different forms: tablet, capsule and suspension.
                    • Less resistance seen to this antibiotic. Your doctor may run tests to see if Bactrim responds to your infection.
                    • Available in generic.
                    • Used to treat many types of bacterial infections.
                    Downsides and risks
                    LevaquinBactrim
                    • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
                    • Levofloxacin can make your skin more sensitive to the sun.
                    • Can't be used if you've ever had myasthenia gravis.
                    • You have to space out any medications with aluminum, magnesium or zinc by at least 2 hours.
                    • Can cause changes in taste, headaches, and insomnia.
                    • Makes your skin more sensitive to the sun.
                    • Has to be taken with plenty of liquids.
                    • May cause birth defects.
                    • Can cause diarrhea.
                    Tips from our pharmacists for people taking the medication
                    LevaquinBactrim
                    • If you notice pain in your Achilles tendons, contact your doctor.
                    • Wear sunscreen if you're going to be out in the sun.
                    • Take the medication exactly how the doctor tells you to.
                    • Take this medication with plenty of fluids.
                    • Space out any medications containing aluminum, magnesium or zinc by at least 2 hours.
                    • Can cause changes in taste, headaches and insomnia.
                    • Can cause diarrhea, nausea or vomiting.
                    • Take this medication exactly how your doctor tells you to.
                    • Can make your skin more sensitive to the sun.
                    • Drink plenty of liquids when taking the medication.
                    • Can cause rash.
                    • Can cause diarrhea, nausea or vomiting.
                    Learn more
                    More about LevaquinSide effectsReviews & ratingsAlternativesFDA package insert
                    More about BactrimSide effectsReviews & ratingsAlternativesFDA package insert