Compare Levaquin vs. Keflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Levaquin (levofloxacin)

Prescription only

Keflex (cephalexin)

Prescription only
Treats bacterial infections.

Levaquin (levofloxacin) effectively treats different types of bacterial infections, but it is relatively more expensive than some of its alternatives.

4.4/ 7 average rating with 90 reviewsforLevaquin
Treats bacterial infections.

Keflex (cephalexin) is good for treating many bacterial infections, and is available as a generic.

5.1/ 7 average rating with 686 reviewsforKeflex
Upsides
  • Available as a generic medicine.
  • Liquid form of Levaquin (levofloxacin) is available for those with trouble swallowing.
  • Treats a variety of bacterial infections.
  • Take only once a day.
  • Can take pill form with or without food.
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Can be taken with or without food.
  • Generally few side effects compared with other antibiotics.
Downsides
  • People with diabetes need to check their blood sugar levels regularly while taking Levaquin (levofloxacin).
  • Can't take Levaquin (levofloxacin) at the same time as antacids or vitamins.
  • Levaquin (levofloxacin) can increase your skin's sensitivity to sunlight and make you more likely to get a rash.
  • Relatively more expensive compared to similar alternatives.
  • Associated with serious and some potentially life-threatening side effects.
  • Can cause diarrhea.
  • You may need to take Keflex (cephalexin) 2 to 4 times a day, which can be hard to remember.
  • If you're allergic to penicillins or other antibiotics, you might not be able to take this medicine.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
Price
Lowest price near you
$4
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Lowest price near you
$9.27
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Reviews
90 
53%
think this treatment is worth it
40%
think this treatment works well
31%
think this treatment is a hassle

Have you used Levaquin (levofloxacin)?

Leave a review
686 
64%
think this treatment is worth it
48%
think this treatment works well
14%
think this treatment is a hassle

Have you used Keflex (cephalexin)?

Leave a review
Side effects
The Levaquin (levofloxacin) FDA package insert doesn’t have numbers about how common side effects are.
The Keflex (cephalexin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Tendon rupture and inflammation

    People over age 60

    ...and 2 more risk factors

  • Myasthenia gravis

    Those with a history of myasthenia gravis

  • Changes in mood and behavior

    Those with a history of depression

  • Effects on heartbeat

    Those with a history of heart rhythm problems

    ...and 2 more risk factors

See more detailed risks and warnings
  • New infections while taking Keflex (cephalexin)

    Weakened immune system

    ...and 1 more risk factors

  • Allergic reaction

    History of penicillin or cephalosporin allergies

See more detailed risks and warnings