Compare Lexapro vs. Anafranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lexapro
(escitalopram)

Anafranil
(clomipramine)

Improves mood and helps you relax. Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions. However, it might not be a good choice if you have liver or heart problems.Helps with your actions. Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.
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Coupons for Lexapro
Best available price for 30 (10mg) tablets of lexapro
Coupons for Anafranil
Best available price for 60 (50mg) capsules of clomipramine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.89Lexapro
Reviews for Lexapro
61%
of people (All ages) say Lexapro is worth it
48%
say it works well
15%
say it's a big hassle
1063 reviews
Have you used Lexapro (escitalopram)?
Worth itNot sureNot worth it

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Have you used Anafranil (clomipramine)?
Worth itNot sureNot worth it
Side effects
LexaproAnafranil
  • Nausea 8%
  • Sleep difficulty 5%
  • Problems with ejaculation 9%
  • Diarrhea 3%
  • Dry mouth 1%
  • Drowsiness 4%
  • Runny nose 1%
  • Fatigue 3%
  • Dizziness 2%
  • Flu-like symptoms 1%
More Lexapro side effects »
  • Dry mouth 67%
  • Tremor 52%
  • Dizziness 40%
  • Drowsiness 38%
  • Headache 11%
  • Constipation 36%
  • Ejaculation failure 40%
  • Fatigue 21%
More Anafranil side effects »
How it works
LexaproAnafranil
Lexapro (escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin in the brain which regulates mood.Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.
Type of medication
LexaproAnafranil
Prescription onlyPrescription only
Available as
LexaproAnafranil
  • Pill
  • Liquid
  • Pill
Used for
LexaproAnafranil
Risk factors for serious side effects
LexaproAnafranil
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Lexapro (escitalopram) suddenly
  • Taking blood thinners
  • Bipolar disorder
Detailed Lexapro (escitalopram) risks & warnings »
  • Age 24 years or younger
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Using other medications that affect serotonin
  • History of seizure
Detailed Anafranil (clomipramine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
LexaproAnafranil
  • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
No interactions related info.
Food
LexaproAnafranil
No food related info.
  • Take it with food and/or at bedtime to decrease the potential side effects.
Sleep
LexaproAnafranil
No sleep related info.
  • Can help you sleep.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
Weight
LexaproAnafranil
  • Can cause a small weight gain of 1-5 pounds.
No weight related info.
Upsides and benefits
LexaproAnafranil
  • Effective at relieving depression and anxiety symptoms.
  • Lowers the likelihood that your depression will come back.
  • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
Downsides and risks
LexaproAnafranil
  • Can cause a small weight gain of 1-5 pounds.
  • Lexapro (escitalopram) is not a good option if you have heart or liver problems.
  • The first antidepressant you try might not always work, so you may need to try a few different medicines until you find one that works for you.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
Tips from our pharmacists for people taking the medication
LexaproAnafranil
  • Don't suddenly stop taking DRUG NAME. Talk to your doctor about how to slowly go down in your dose to avoid withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Like other SSRI medications, it could take up to 8 weeks to see the full effects of Lexapro (escitalopram).
  • Take Lexapro (escitalopram) in the morning since it can keep you up if you take it at night.
  • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
  • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
Learn more
More about LexaproSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lexapro (escitalopram)?
Worth itNot sureNot worth it
More about AnafranilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Anafranil (clomipramine)?
Worth itNot sureNot worth it