Compare Lexapro vs. Anafranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lexapro (escitalopram)

Prescription only

Anafranil (Clomipramine)

Prescription only
Improves mood and helps you relax.

Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions. However, it might not be a good choice if you have liver or heart problems.

4.9/ 7 average rating with 1063 reviewsforLexapro
Helps with your actions.

Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.

Upsides
  • Effective at relieving depression and anxiety symptoms.
  • Lowers the likelihood that your depression will come back.
  • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
Downsides
  • Can cause a small weight gain of 1-5 pounds.
  • Lexapro (escitalopram) is not a good option if you have heart or liver problems.
  • The first antidepressant you try might not always work, so you may need to try a few different medicines until you find one that works for you.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price near you
$9.9
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Lowest price near you
$176.64
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Reviews
1063 
61%
think this treatment is worth it
48%
think this treatment works well
15%
think this treatment is a hassle

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Side effects
10possible side effects
  • Headache
    24%
  • Nausea
    18%
  • Problems ejaculating
    14%
  • Sleepiness
    13%
  • Insomnia
    12%
  • Dry mouth
    9%
  • Diarrhea
    8%
  • Fatigue
    8%
  • Decreased libido
    7%
  • Problems with orgasm
    6%
See more detailed side effects
8possible side effects
  • Dry mouth
    84%
  • Somnolence
    54%
  • Tremor
    54%
  • Dizziness
    54%
  • Headache
    52%
  • Constipation
    47%
  • Ejaculation failure
    42%
  • Fatigue
    39%
See more detailed side effects
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Withdrawal

    Stopping Lexapro (escitalopram) suddenly

  • Increased bleeding

    Taking blood thinners

  • Uncovering of bipolar disorder

    Bipolar disorder

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Seizure

    History of seizure

    ...and 2 more risk factors

  • Withdrawal

    Stopping Anafranil (Clomipramine) suddenly

  • Low blood pressure

    Age 65 years or older

  • Heart problems

    History of heart disease

    ...and 2 more risk factors

See more detailed risks and warnings