Compare Lexapro vs. Cymbalta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lexapro
(Escitalopram)

Cymbalta
(Duloxetine)

Improves mood and helps you relax. Lexapro (Escitalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.832985386221294Lexapro
Reviews for Lexapro (Escitalopram)
59%
of people say Lexapro (Escitalopram) is worth it
46%
say it works well
15%
say it's a big hassle
Reviews for Cymbalta (Duloxetine)
59%
Same vs. Lexapro (Escitalopram)
49%
+3% vs. Lexapro (Escitalopram)
24%
9% vs. Lexapro (Escitalopram)
Side effects
LexaproCymbalta
  • Ejaculation disorder 12%
  • Ejaculation disorder (primarily ejaculatory delay) 11%
  • Sleep difficulty 10%
  • Nausea 10%
  • Diarrhea 9%
  • Headache 7%
  • Drowsiness 6%
  • Fatigue 6%
  • Dizziness 5%
  • Lower sex drive 5%
More Lexapro side effects »
  • Nausea 15%
  • Dry mouth 8%
  • Drowsiness 8%
  • Constipation 7%
  • Somnolencee 7%
  • Decreased appetite 7%
  • Fatigued 6%
  • Sleep difficulty 5%
  • Dizziness 4%
  • Fatigue 4%
More Cymbalta side effects »
How it works
LexaproCymbalta
Lexapro (Escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.
Type of medication
LexaproCymbalta
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Available as
LexaproCymbalta
  • Pill
  • Liquid
  • Extended release
Used for (click to learn more)
LexaproCymbalta
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

After 4 weeks using Start and Lexapro (Escitalopram), here’s how much better people feel.

After 4 weeks using Start and Cymbalta (Duloxetine), here’s how much better people feel.

Risk factors for serious side effects
LexaproCymbalta
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Lexapro (Escitalopram) suddenly
  • Higher dose
  • History of heart problems
  • History of liver problems
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Lexapro (Escitalopram) risks & warnings »
    • Age 24 years or younger
    • Using other medications that affect serotonin
    • Stopping Cymbalta (Duloxetine) suddenly
    • History of high blood pressure
    • Taking other blood-thinning drugs
      • History of bipolar disorder
      • At risk for bipolar disorder
      Detailed Cymbalta (Duloxetine) risks & warnings »
      Pregnancy category
      LexaproCymbalta
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      • Take with food to avoid upset stomach.
      • Take with food to avoid upset stomach.
      Kidneys and liver
      No specific kidneys and liver-related info.
      • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
      Sex
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • Lexapro (Escitalopram) can cause lower sex drive or difficulty having an orgasm. If the problem persists after the first 2 to 3 months, you can talk to your doctor about alternative antidepressants or performance-enhancing medications.
      • Cymbalta (Duloxetine) can cause lower sex drive or difficulty having an orgasm. If the problem persists after the first 2 to 3 months, you can talk to your doctor about alternative antidepressants or performance-enhancing medications.
      Sleep
      • Stopping Lexapro (Escitalopram) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3 days of stopping the medication, and go away within 1 to 2 weeks. Work with your doctor to gradually reduce your dose.
      • Stopping Cymbalta (Duloxetine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3 days of stopping the medication, and go away within 1 to 2 weeks. Work with your doctor to gradually reduce your dose.
      Weight
      • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
      No specific weight-related info.
      Upsides and benefits
      LexaproCymbalta
      • Lowers relapse rates of depression.
      • Causes less sleepiness than some other antidepressants.
      • Effective at relieving depression and anxiety symptoms.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      • Lowers relapse rates for depression.
      • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
      • Effective at relieving depression and anxiety symptoms.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      Downsides and risks
      LexaproCymbalta
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
      • Can cause an irregular heartbeat if you take a high dose (20 mg a day, or more).
      • Not a good option for you if you have heart or liver problems.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
      • The first antidepressant you try doesn't always work, and might have side effects you really don't like. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
      • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
      • Not the best option for people with high blood pressure.
      • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Tips from our pharmacists for people taking the medication
      LexaproCymbalta
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Take with food to avoid upset stomach.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
      • Stop taking slowly to avoid withdrawal symptoms.
      • Take with food to avoid upset stomach.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      Learn more
      More about LexaproSide effectsReviews & ratingsAlternativesFDA package insert
      More about CymbaltaSide effectsReviews & ratingsAlternativesFDA package insert