Compare Lexapro vs. nefazodone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lexapro
(escitalopram)

Serzone
(nefazodone)

Improves mood and helps you relax. Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions. However, it might not be a good choice if you have liver or heart problems.Treats depression. Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.89Lexapro
Reviews for Lexapro
61%
of people (All ages) say Lexapro is worth it
48%
say it works well
15%
say it's a big hassle
1063 reviews
Have you used Lexapro (escitalopram)?
Worth itNot sureNot worth it

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Have you used Serzone (nefazodone)?
Worth itNot sureNot worth it
Side effects
Lexapronefazodone
  • Nausea 8%
  • Insomnia 5%
  • Problems with ejaculation 9%
  • Diarrhea 3%
  • Dry Mouth 1%
  • Somnolence 4%
  • Runny nose 1%
  • Fatigue 3%
  • Dizziness 2%
  • Flu-like symptoms 1%
More Lexapro side effects »
  • Headache 3%
  • Sleepiness 11%
  • Dry mouth 12%
  • Nausea 10%
  • Dizziness 12%
  • Constipation 6%
  • Weakness 6%
  • Trouble sleeping 2%
  • Lightheadedness 7%
  • Indigestion 2%
More nefazodone side effects »
How it works
Lexapronefazodone
Lexapro (escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin in the brain which regulates mood.Serzone (nefazodone) is a serotonin reuptake inhibitor. Serzone (nefazodone) raises the amount of serotonin in the brain, which helps to regulate your mood.
Type of medication
Lexapronefazodone
Prescription onlyPrescription only
Available as
Lexapronefazodone
  • Pill
  • Liquid
  • Pill
Used for
Lexapronefazodone
Risk factors for serious side effects
Lexapronefazodone
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Lexapro (escitalopram) suddenly
  • Taking blood thinners
  • Bipolar disorder
Detailed Lexapro (escitalopram) risks & warnings »
  • People under age 24
  • Taking medicine for high blood pressure
  • History of seizures
  • History of heart attack or heart disease
  • Medicines that slow the heartbeat
Detailed Serzone (nefazodone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
Lexapronefazodone
  • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
Pain
Lexapronefazodone
No pain related info.
  • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.
Weight
Lexapronefazodone
  • Can cause a small weight gain of 1-5 pounds.
No weight related info.
Upsides and benefits
Lexapronefazodone
  • Effective at relieving depression and anxiety symptoms.
  • Lowers the likelihood that your depression will come back.
  • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
  • Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
  • Serzone (nefazodone) is available in generic.
Downsides and risks
Lexapronefazodone
  • Can cause a small weight gain of 1-5 pounds.
  • Lexapro (escitalopram) is not a good option if you have heart or liver problems.
  • The first antidepressant you try might not always work, so you may need to try a few different medicines until you find one that works for you.
  • While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
  • Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
  • It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
Tips from our pharmacists for people taking the medication
Lexapronefazodone
  • Don't suddenly stop taking DRUG NAME. Talk to your doctor about how to slowly go down in your dose to avoid withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Like other SSRI medications, it could take up to 8 weeks to see the full effects of Lexapro (escitalopram).
  • Take Lexapro (escitalopram) in the morning since it can keep you up if you take it at night.
  • You may not notice any changes in your mood until you've taken Serzone (nefazodone) for at least 2 weeks. The full effects may not happen for at least 2 to 3 months.
  • Don't drive or do anything requiring concentration until you know how Serzone (nefazodone) affects you because it can make you feel dizzy.
  • If you forget a dose of Serzone (nefazodone), take it as soon as you remember. If it's time for your next dose, don't take 2 doses at the same time to make up for the missed dose.
  • Store Serzone (nefazodone) in your pantry away from heat, light, and moisture.
  • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.
Learn more
More about LexaproSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lexapro (escitalopram)?
Worth itNot sureNot worth it
More about nefazodoneSide effectsAlternativesFDA package insert
Have you used Serzone (nefazodone)?
Worth itNot sureNot worth it