Compare Lexapro vs. nefazodone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lexapro (escitalopram)

Prescription only

Serzone (nefazodone)

Prescription only
Improves mood and helps you relax.

Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions. However, it might not be a good choice if you have liver or heart problems.

3.6/ 5 average rating with 1063 reviewsforLexapro
Treats depression.

Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.

Upsides
  • Effective at relieving depression and anxiety symptoms.
  • Lowers the likelihood that your depression will come back.
  • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
  • Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
  • Serzone (nefazodone) is available in generic.
Downsides
  • Can cause a small weight gain of 1-5 pounds.
  • Lexapro (escitalopram) is not a good option if you have heart or liver problems.
  • The first antidepressant you try might not always work, so you may need to try a few different medicines until you find one that works for you.
  • While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
  • Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
  • It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
No pricing information available
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Reviews
1063 reviews so far
61%
saidit'sworth it
48%
saiditworked well
15%
saidit'sa big hassle

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Side effects
25possible side effects
  • Headache
    24%
  • Nausea
    18%
  • Problems ejaculating
    14%
  • Sleepiness
    13%
  • Insomnia
    12%
  • Dry mouth
    9%
  • Diarrhea
    8%
  • Fatigue
    8%
  • Decreased libido
    7%
  • Problems with orgasm
    6%
  • Constipation
    5%
  • Flu-like symptoms
    5%
  • Increased sweating
    4%
  • Indigestion
    3%
  • Vomiting
    3%
  • Neck/shoulder pain
    3%
  • Abnormal dreams
    3%
  • Decrease appetite
    3%
  • Lack of energy
    3%
  • Tingling or burning in the hands/feet
    2%
  • Abdominal pain
    2%
  • Flatulence
    2%
  • Toothache
    2%
  • Yawning
    2%
  • Menstrual disorder
    2%
See more detailed side effects
42possible side effects
  • Headache
    36%
  • Dry mouth
    25%
  • Sleepiness
    25%
  • Nausea
    22%
  • Dizziness
    17%
  • Constipation
    14%
  • Weakness
    11%
  • Trouble sleeping
    11%
  • Lightheadedness
    10%
  • Indigestion
    9%
  • Blurry vision
    9%
  • Infection
    8%
  • Diarrhea
    8%
  • Confusion
    7%
  • Blind spots in vision
    7%
  • Sore throat
    6%
  • Increased appetite
    5%
  • Changes in blood pressure
    4%
  • Memory problems
    4%
  • Tingling or prickling sensation
    4%
  • Flushing
    4%
  • Flu
    3%
  • Swelling in the arms and legs
    3%
  • Abnormal dreams
    3%
  • Decreased concentration
    3%
  • Increased cough
    3%
  • Chills
    2%
  • Fever
    2%
  • Low blood pressure
    2%
  • Itching
    2%
  • Skin rashes
    2%
  • Nausea and vomiting
    2%
  • Trouble controlling movements
    2%
  • Coordination problems
    2%
  • Slowing of movement or speech
    2%
  • Tremor
    2%
  • Ringing in the ears
    2%
  • Changes in taste
    2%
  • Frequent urination
    2%
  • Urinary tract infection
    2%
  • Problems emptying bladder
    2%
  • Vaginal discharge, itching, and pain
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Withdrawal
    • Stopping Lexapro (escitalopram) suddenly
  • Increased bleeding
    • Taking blood thinners
  • Sexual problems
  • Uncovering of bipolar disorder
    • Bipolar disorder
See more detailed risks and warnings
  • Higher risk of suicide
    • People under age 24
  • Liver failure
  • Low blood pressure
    • Taking medicine for high blood pressure
  • Possible bipolar disorder
  • Seizures
    • History of seizures
  • Lower heart rate
    • History of heart attack or heart disease
    • Medicines that slow the heartbeat
See more detailed risks and warnings