Compare Lexapro vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lexapro
(escitalopram)

Oleptro
(Trazodone)

Improves mood and helps you relax. Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions. However, it might not be a good choice if you have liver or heart problems.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.89Lexapro
Reviews for Lexapro
61%
of people (All ages) say Lexapro is worth it
48%
say it works well
15%
say it's a big hassle
1063 reviews
Have you used Lexapro (escitalopram)?
Worth itNot sureNot worth it
Reviews for Oleptro
73%
-12% worse vs. Lexapro
49%
-1% worse vs. Lexapro
24%
+9% better vs. Lexapro
Have you used Oleptro (Trazodone)?
Worth itNot sureNot worth it
Side effects
LexaproOleptro
  • Abdominal pain 1%
  • Problems with orgasm 2%
  • Constipation 2%
  • Indigestion 2%
  • Decreased appetite 2%
  • Decrease libido 2%
  • Sinus infection 1%
  • Impotence 3%
  • Increased sweating 3%
  • Dizziness 2%
More Lexapro side effects »
  • Incoordination 2%
  • Ejaculation disorders 2%
  • Decreased libido 2%
  • Hypotension 4%
  • Diarrhea 3%
  • Syncope 4%
  • Musculoskeletal Aches/Pains 2%
  • Tremors 1%
  • Weight Gain 3%
More Oleptro side effects »
How it works
LexaproOleptro
Lexapro (escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin in the brain which regulates mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
LexaproOleptro
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
LexaproOleptro
  • Pill
  • Liquid
  • Pill
  • Extended release
Used for
LexaproOleptro
Risk factors for serious side effects
LexaproOleptro
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Lexapro (escitalopram) suddenly
  • Taking blood thinners
  • Bipolar disorder
Detailed Lexapro (escitalopram) risks & warnings »
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
Detailed Oleptro (Trazodone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
LexaproOleptro
  • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
No interactions related info.
Weight
LexaproOleptro
  • Can cause a small weight gain of 1-5 pounds.
No weight related info.
Upsides and benefits
LexaproOleptro
  • Effective at relieving depression and anxiety symptoms.
  • Lowers the likelihood that your depression will come back.
  • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
LexaproOleptro
  • Can cause a small weight gain of 1-5 pounds.
  • Lexapro (escitalopram) is not a good option if you have heart or liver problems.
  • The first antidepressant you try might not always work, so you may need to try a few different medicines until you find one that works for you.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
LexaproOleptro
  • Don't suddenly stop taking DRUG NAME. Talk to your doctor about how to slowly go down in your dose to avoid withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Like other SSRI medications, it could take up to 8 weeks to see the full effects of Lexapro (escitalopram).
  • Take Lexapro (escitalopram) in the morning since it can keep you up if you take it at night.
  • Makes you sleepy. Take at bedtime.
  • Can cause temporary dry mouth and upset stomach.
  • Seek medical attention for unwanted, persistent erection.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about LexaproSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lexapro (escitalopram)?
Worth itNot sureNot worth it
More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oleptro (Trazodone)?
Worth itNot sureNot worth it