Compare Lexapro vs. nefazodone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lexapro (escitalopram)

Prescription only

Serzone (nefazodone)

Prescription only
Improves mood and helps you relax.

Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions. However, it might not be a good choice if you have liver or heart problems.

4.9/ 7 average rating with 1063 reviewsforLexapro
Treats depression.

Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.

Upsides
  • Effective at relieving depression and anxiety symptoms.
  • Lowers the likelihood that your depression will come back.
  • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
  • Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
  • Serzone (nefazodone) is available in generic.
Downsides
  • Can cause a small weight gain of 1-5 pounds.
  • Lexapro (escitalopram) is not a good option if you have heart or liver problems.
  • The first antidepressant you try might not always work, so you may need to try a few different medicines until you find one that works for you.
  • While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
  • Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
  • It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
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$9.9
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Reviews
1063 
61%
think this treatment is worth it
48%
think this treatment works well
15%
think this treatment is a hassle

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Side effects
10possible side effects
  • Headache
    24%
  • Nausea
    18%
  • Problems ejaculating
    14%
  • Sleepiness
    13%
  • Insomnia
    12%
  • Dry mouth
    9%
  • Diarrhea
    8%
  • Fatigue
    8%
  • Decreased libido
    7%
  • Problems with orgasm
    6%
See more detailed side effects
10possible side effects
  • Headache
    36%
  • Dry mouth
    25%
  • Sleepiness
    25%
  • Nausea
    22%
  • Dizziness
    17%
  • Constipation
    14%
  • Weakness
    11%
  • Trouble sleeping
    11%
  • Lightheadedness
    10%
  • Indigestion
    9%
See more detailed side effects
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Withdrawal

    Stopping Lexapro (escitalopram) suddenly

  • Increased bleeding

    Taking blood thinners

  • Uncovering of bipolar disorder

    Bipolar disorder

See more detailed risks and warnings
  • Higher risk of suicide

    People under age 24

  • Low blood pressure

    Taking medicine for high blood pressure

  • Seizures

    History of seizures

  • Lower heart rate

    History of heart attack or heart disease

    ...and 1 more risk factors

See more detailed risks and warnings