Compare Lexapro vs. Wellbutrin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lexapro
(escitalopram)

Wellbutrin
(Bupropion)

Improves mood and helps you relax. Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions. However, it might not be a good choice if you have liver or heart problems.Improves mood. Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.89Lexapro
Reviews for Lexapro
61%
of people (All ages) say Lexapro is worth it
48%
say it works well
15%
say it's a big hassle
1063 reviews
Have you used Lexapro (escitalopram)?
Worth itNot sureNot worth it
Reviews for Wellbutrin
60%
+1% better vs. Lexapro
40%
+8% better vs. Lexapro
13%
-2% worse vs. Lexapro
1164 reviews
Have you used Wellbutrin (Bupropion)?
Worth itNot sureNot worth it
Side effects
LexaproWellbutrin
  • Abdominal pain 1%
  • Problems with orgasm 2%
  • Constipation 2%
  • Indigestion 2%
  • Decreased appetite 2%
  • Decrease libido 2%
  • Sinus infection 1%
  • Impotence 3%
  • Increased sweating 3%
  • Dizziness 2%
More Lexapro side effects »
  • Anxiety 2%
  • Decreased libido 1%
  • Gustatory disturbance 2%
  • Dyspepsia 1%
  • Hypotension 1%
  • Impaired sleep quality 2%
  • Sensory disturbance 1%
  • Appetite increase 2%
  • Palpitations 2%
More Wellbutrin side effects »
How it works
LexaproWellbutrin
Lexapro (escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin in the brain which regulates mood.Wellbutrin (Bupropion) is an atypical antidepressant. Researchers don't know exactly how it works, but it seems to change dopamine and norepinephrine activity in the brain, which regulate mood.
Type of medication
LexaproWellbutrin
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
LexaproWellbutrin
  • Pill
  • Liquid
  • Pill
  • Extended release
Used for
LexaproWellbutrin
Risk factors for serious side effects
LexaproWellbutrin
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Lexapro (escitalopram) suddenly
  • Taking blood thinners
  • Bipolar disorder
Detailed Lexapro (escitalopram) risks & warnings »
  • Age 24 years or younger
  • History of depression
  • History of bipolar disorder
  • At risk for bipolar disorder
  • Withdrawing from nicotine
Detailed Wellbutrin (Bupropion) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
LexaproWellbutrin
  • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
No interactions related info.
Alcohol
LexaproWellbutrin
No alcohol related info.
  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
Kidneys and liver
LexaproWellbutrin
No kidneys and liver related info.
  • Wellbutrin (Bupropion) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent increased risk for side effects.
Weight
LexaproWellbutrin
  • Can cause a small weight gain of 1-5 pounds.
  • It's less likely to cause weight gain than other antidepressants.
Upsides and benefits
LexaproWellbutrin
  • Effective at relieving depression and anxiety symptoms.
  • Lowers the likelihood that your depression will come back.
  • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
  • Effective at relieving depression symptoms.
  • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
  • Can be taken with other antidepressants to counteract their sexual side effects.
  • Has some stimulant effects, so it can be energizing.
  • Can help with ADHD symptoms.
  • Also used to suppress appetite and help you quit smoking.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
LexaproWellbutrin
  • Can cause a small weight gain of 1-5 pounds.
  • Lexapro (escitalopram) is not a good option if you have heart or liver problems.
  • The first antidepressant you try might not always work, so you may need to try a few different medicines until you find one that works for you.
  • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
  • Generally not as good as other antidepressants for people who have anxiety.
  • It's less likely to cause weight gain than other antidepressants.
  • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
  • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
LexaproWellbutrin
  • Don't suddenly stop taking DRUG NAME. Talk to your doctor about how to slowly go down in your dose to avoid withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Like other SSRI medications, it could take up to 8 weeks to see the full effects of Lexapro (escitalopram).
  • Take Lexapro (escitalopram) in the morning since it can keep you up if you take it at night.
  • Wellbutrin (Bupropion) makes you energized, so take it in the morning to avoid difficulty sleeping later that night.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • There are no sexual side effects from this medication.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • The extended-release tablet shell can show up unchanged in your stool, but don't worry since the medication was still absorbed by your body.
Learn more
More about LexaproSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lexapro (escitalopram)?
Worth itNot sureNot worth it
More about WellbutrinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Wellbutrin (Bupropion)?
Worth itNot sureNot worth it