Compare Lexapro vs. Wellbutrin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lexapro
(Escitalopram)

Wellbutrin
(Bupropion)

Improves mood and helps you relax. Lexapro (Escitalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood. Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.89Lexapro
Reviews for Lexapro (Escitalopram)
61%
of people (All ages) say Lexapro (Escitalopram) is worth it
48%
say it works well
15%
say it's a big hassle
1063 reviews
Have you used Lexapro (Escitalopram)?
Worth itNot sureNot worth it
Reviews for Wellbutrin (Bupropion)
60%
-1% worse vs. Lexapro (Escitalopram)
40%
-8% worse vs. Lexapro (Escitalopram)
13%
+2% better vs. Lexapro (Escitalopram)
1164 reviews
Have you used Wellbutrin (Bupropion)?
Worth itNot sureNot worth it
Side effects
LexaproWellbutrin
  • Nausea 8%
  • Ejaculation disorder 9%
  • Sleep difficulty 5%
  • Diarrhea 3%
  • Dry mouth 1%
  • Drowsiness 4%
  • Inflammation inside the nose 1%
  • Dizziness 2%
  • Flu-like symptomsa-like symptoms 1%
  • Sweating increased 3%
More Lexapro side effects »
  • Agitation 10%
  • Dry mouth 10%
  • Headache/migraine 4%
  • Constipation 9%
  • Nausea/vomiting 4%
  • Excessive sweating 7%
  • Dizziness 6%
  • Tremor 13%
  • Sleep difficulty 3%
More Wellbutrin side effects »
How it works
LexaproWellbutrin
Lexapro (Escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Wellbutrin (Bupropion) is an atypical antidepressant. Researchers don't know exactly how it works, but it seems to change dopamine and norepinephrine activity in the brain, which regulate mood.
Type of medication
LexaproWellbutrin
Prescription only
Prescription only
Available as
LexaproWellbutrin
  • Pill
  • Liquid
  • Pill
  • Extended release
Used for
LexaproWellbutrin
Risk factors for serious side effects
LexaproWellbutrin
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Lexapro (Escitalopram) suddenly
  • Higher dose
  • History of heart problems
  • History of liver problems
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Lexapro (Escitalopram) risks & warnings »
    • Age 24 years or younger
    • History of depression
    • History of bipolar disorder
    • At risk for bipolar disorder
    • Withdrawing from nicotine
    • History of seizures
    • Alcoholism
    • Eating disorder
    • Higher dose
    • Drug interactions
    • History of bipolar disorder
    • At risk for bipolar disorder
    • Current kidney problems
    • Current liver problems
      Detailed Wellbutrin (Bupropion) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Alcohol
      LexaproWellbutrin
      No alcohol related info.
      • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
      Food
      LexaproWellbutrin
      • Take with food to avoid upset stomach.
      No food related info.
      Kidneys and liver
      LexaproWellbutrin
      • Not a good option for you if you have heart or liver problems.
      • Wellbutrin (Bupropion) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent increased risk for side effects.
      Sex
      LexaproWellbutrin
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      No sex related info.
      Weight
      LexaproWellbutrin
      • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
      • It's less likely to cause weight gain than other antidepressants.
      Upsides and benefits
      LexaproWellbutrin
      • Effective at relieving depression and anxiety symptoms.
      • Lowers relapse rates of depression.
      • Causes less sleepiness than some other antidepressants.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      • Effective at relieving depression symptoms.
      • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
      • Can be taken with other antidepressants to counteract their sexual side effects.
      • Has some stimulant effects, so it can be energizing.
      • Can help with ADHD symptoms.
      • Also used to suppress appetite and help you quit smoking.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      Downsides and risks
      LexaproWellbutrin
      • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
      • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
      • Can cause an irregular heartbeat if you take a high dose (20 mg a day, or more).
      • Not a good option for you if you have heart or liver problems.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
      • The first antidepressant you try doesn't always work, and might have side effects you really don't like. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
      • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
      • Generally not as good as other antidepressants for people who have anxiety.
      • It's less likely to cause weight gain than other antidepressants.
      • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
      • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Tips from our pharmacists for people taking the medication
      LexaproWellbutrin
      • Take with food to avoid upset stomach.
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • Wellbutrin (Bupropion) makes you energized, so take it in the morning to avoid difficulty sleeping later that night.
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • There are no sexual side effects from this medication.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • The extended-release tablet shell can show up unchanged in your stool, but don't worry since the medication was still absorbed by your body.
      Learn more
      More about LexaproSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Lexapro (Escitalopram)?
      Worth itNot sureNot worth it
      More about WellbutrinSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Wellbutrin (Bupropion)?
      Worth itNot sureNot worth it