Compare Lexapro vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lexapro
(escitalopram)

Zoloft
(sertraline)

Improves mood and helps you relax. Lexapro (escitalopram) is good for treating depression and anxiety. It is less likely to cause side effects than and has fewer drug interactions. However, it might not be a good choice if you have liver or heart problems.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.
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Prices and coupon for 30 (10mg) tablets of escitalopram
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Prices and coupon for 30 (100mg) tablets of sertraline
Reviews & ratings
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4.89Lexapro
Reviews for Lexapro (escitalopram)
61%
of people (All ages) say Lexapro (escitalopram) is worth it
48%
say it works well
15%
say it's a big hassle
1063 reviews
Have you used Lexapro (escitalopram)?
Worth itNot sureNot worth it
Reviews for Zoloft (sertraline)
59%
-2% worse vs. Lexapro (escitalopram)
41%
-7% worse vs. Lexapro (escitalopram)
15%
Same vs. Lexapro (escitalopram)
1472 reviews
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it
Side effects
LexaproZoloft
  • Nausea 8%
  • Sleep difficulty 5%
  • Problems with ejaculation 9%
  • Diarrhea 3%
  • Dry mouth 1%
  • Drowsiness 4%
  • Runny nose 1%
  • Fatigue 3%
  • Dizziness 2%
  • Flu-like symptoms 1%
More Lexapro side effects »
  • Nausea 10%
  • Diarrhea/loose stools 6%
  • Sleep difficulty 2%
  • Mouth dry 7%
  • Fatigue 10%
  • Dizziness 2%
  • Feeling unwell 2%
  • Indigestion 4%
  • Loss of appetite 5%
  • Lower sex drive 2%
More Zoloft side effects »
How it works
LexaproZoloft
Lexapro (escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin in the brain which regulates mood.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.
Type of medication
LexaproZoloft
Prescription only
Prescription only
Available as
LexaproZoloft
  • Pill
  • Liquid
  • Pill
  • Liquid
Used for
LexaproZoloft
Risk factors for serious side effects
LexaproZoloft
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Lexapro (escitalopram) suddenly
  • Taking blood thinners
    • Bipolar disorder
    Detailed Lexapro (escitalopram) risks & warnings »
    • Under 24 years old
    • Interactions with other medications
        • Stopping Zoloft (Sertraline) suddenly
        • Taking with blood-thinning drugs
        • Elderly
        • Taking with diuretic medications
        Detailed Zoloft (sertraline) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Interactions
        LexaproZoloft
        • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
        • It interacts with St. John's Wort and Tryptophan.
        Sex
        LexaproZoloft
        No sex related info.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        Sleep
        LexaproZoloft
        No sleep related info.
        • Causes less drowsiness than other antidepressants.
        • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
        Weight
        LexaproZoloft
        • Can cause a small weight gain of 1-5 pounds.
        No weight related info.
        Upsides and benefits
        LexaproZoloft
        • Effective at relieving depression and anxiety symptoms.
        • Lowers the likelihood that your depression will come back.
        • Lexapro (escitalopram) has less drug interactions than other similar antidepressants and might cause fewer side effects.
        • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
        • Causes less drowsiness than other antidepressants.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        LexaproZoloft
        • Can cause a small weight gain of 1-5 pounds.
        • Lexapro (escitalopram) is not a good option if you have heart or liver problems.
        • The first antidepressant you try might not always work, so you may need to try a few different medicines until you find one that works for you.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • More likely to cause diarrhea than other antidepressants.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        LexaproZoloft
        • Don't suddenly stop taking DRUG NAME. Talk to your doctor about how to slowly go down in your dose to avoid withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • Like other SSRI medications, it could take up to 8 weeks to see the full effects of Lexapro (escitalopram).
        • Take Lexapro (escitalopram) in the morning since it can keep you up if you take it at night.
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • It interacts with St. John's Wort and Tryptophan.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about LexaproSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Lexapro (escitalopram)?
        Worth itNot sureNot worth it
        More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Zoloft (sertraline)?
        Worth itNot sureNot worth it