Compare Lidocaine vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lidoderm (Lidocaine)

Prescription only

Pamelor (Nortriptyline)

Prescription only
Treats nerve pain.

Lidoderm (Lidocaine) patches work well by releasing a local anesthetic into the skin and relieving pain by targeting damaged nerves.

4.2/ 5 average rating with 18 reviewsforLidocaine
Improves your mood.

Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

4.0/ 5 average rating with 19 reviewsforPamelor
Upsides
  • Lidoderm (Lidocaine) can treat pain better for people who can't take oral pain medications due to allergies or bad side effects.
  • Has been shown to relieve nerve pain due to shingles for up to 12 hours at a time.
  • Patches can be cut into smaller pieces to best fit the areas of skin they need to be used on.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
Downsides
  • Can cause skin irritation after using it the first time, but for most people it's mild and goes away in a few minutes or hours.
  • Used patches contain enough medicine to be dangerous to children and pets, so store and dispose of the patches in a safe place out of their reach.
  • Might not be the best choice if you've had allergic reactions to numbing medications (local anesthetics) in the past.
  • Even though only small amounts of Lidoderm (Lidocaine) are absorbed into the body through the skin, if you're taking medications that treat arrhythmias, Lidoderm (Lidocaine) can affect how they work.
  • Patches shouldn't be left on for more than 12 hours, used on very large areas of skin, or covered with a heating pad.
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
Used for
Dosage forms
  • Cream, gel, or ointment
  • Jelly
  • Spray
  • Topical solution
  • Patch
  • Pill
  • Liquid
Price
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Reviews
18 reviews so far
67%
saidit'sworth it
72%
saiditworked well
22%
saidit'sa big hassle

Have you used Lidoderm (Lidocaine)?

Leave a review
19 reviews so far
79%
saidit'sworth it
79%
saiditworked well
21%
saidit'sa big hassle

Have you used Pamelor (Nortriptyline)?

Leave a review
Side effects
The Lidoderm (Lidocaine) FDA package insert doesn’t have numbers about how common side effects are.
The Pamelor (Nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Overdose
    • Use of heating pad on skin
    • Applying patch to red, irritated or broken skin
    • Leaving patch on for more than 12 hours
    • Using patch on a very large area
    • Older age and lower body weight
    • Liver disease
  • Serious allergic reaction
    • Allergy to numbing medications (local anesthetics)
  • Accidental poisoning
    • Not disposing of Lidoderm (Lidocaine) correctly
    • Children and pets can reach medication
  • Eye irritation
    • Not washing hands after touching or applying Lidoderm (Lidocaine)
  • Skin reactions
    • Applying Lidoderm (Lidocaine) to warm skin
    • Covering patch with wrap or heating pad
  • Heart problems
    • History of heart problems
    • Using Lidoderm (Lidocaine) with drugs to treat irregular heartbeat
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Low blood pressure
    • Age 65 years or older
  • Withdrawal
    • Stopping Pamelor (Nortriptyline) suddenly
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Heart problems
    • History of heart disease
    • Older age
    • Electrolyte imbalance
See more detailed risks and warnings
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Disclaimer: We don't provide medical advice. If you think you might have a medical emergency, call your doctor or 911 immediately.