Compare Lidocaine vs. Topamax

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Qudexy Xr

Treats nerve pain. Lidoderm (Lidocaine) patches work well by releasing a local anesthetic into the skin and relieving pain by targeting damaged nerves.Prevents seizures and migraine headaches. Qudexy Xr (Topiramate) is useful for preventing seizures and migraines, and doesn't require blood tests while you're on it.
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Reviews & ratings
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Reviews for Qudexy Xr (Topiramate)
6% vs. Lidoderm (Lidocaine)
15% vs. Lidoderm (Lidocaine)
13% vs. Lidoderm (Lidocaine)
Side effects

The Lidocaine FDA package insert doesn’t have numbers about how common side effects are.

More about Lidocaine side effects »
  • Tingling sensation 45%
  • Slowed-down thinking and movements 19%
  • Dizziness 17%
  • Drowsiness 17%
  • Fatigue 17%
  • Change in taste 14%
  • Difficulty with concentration/attention 13%
  • Nervousness 12%
  • Difficulty with memory 11%
  • Vision abnormal 11%
More Topamax side effects »
How it works
Lidoderm (Lidocaine) is a local anesthetic. It absorbs into your skin where it targets damaged nerves and relieves burning pain.Qudexy Xr (Topiramate) is an antiepileptic. Researchers don't know exactly how it works, but it seems to affect multiple parts of the brain to control seizures and migraines.
Type of medication
Local anestheticPrescription only
AnticonvulsantPrescription only
Available as
  • Cream, gel, or ointment
  • Jelly
  • Spray
  • Topical solution
  • Patch
  • Pill
  • Extended release capsule
Used for (click to learn more)
Risk factors for serious side effects
  • Use of heating pad on skin
  • Applying patch to red, irritated or broken skin
  • Leaving patch on for more than 12 hours
  • Using patch on a very large area
  • Older age and lower body weight
  • Liver disease
  • Allergy to numbing medications (local anesthetics)
  • Not disposing of Lidoderm (Lidocaine) correctly
  • Children and pets can reach medication
  • Not washing hands after touching or applying Lidoderm (Lidocaine)
  • Applying Lidoderm (Lidocaine) to warm skin
  • Covering patch with wrap or heating pad
  • History of heart problems
  • Using Lidoderm (Lidocaine) with drugs to treat irregular heartbeat
Detailed Lidoderm (Lidocaine) risks & warnings »
  • History of depression
    • Children
    • History of metabolic disorders
    • People also taking Depakote
    • Low-carb diet
    • Dehydration
    • Drug interactions
      • Stopping Qudexy Xr (Topiramate) suddenly
      Detailed Qudexy Xr (Topiramate) risks & warnings »
      Pregnancy category
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      No specific alcohol-related info.No specific alcohol-related info.
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.
      • A few people will get kidney stones.
      • Qudexy Xr (Topiramate) may increase your risk for kidney stones. Stay well-hydrated to lower your risk.
      No specific sex-related info.No specific sex-related info.
      No specific sleep-related info.No specific sleep-related info.
      No specific weight-related info.
      • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
      Upsides and benefits
      • Lidoderm (Lidocaine) can treat pain better for people who can't take oral pain medications due to allergies or bad side effects.
      • Has been shown to relieve nerve pain due to shingles for up to 12 hours at a time.
      • Patches can be cut into smaller pieces to best fit the areas of skin they need to be used on.
      • Used on its own or with other antiepileptic medicines to lower the frequency of seizures, especially for people with tonic-clonic or partial seizures, or Lennox-Gestaut syndrome.
      • Helpful in preventing frequent migraine headaches.
      • Doesn't need routine blood tests.
      Downsides and risks
      • Can cause skin irritation after using it the first time, but for most people it's mild and goes away in a few minutes or hours.
      • Used patches contain enough medicine to be dangerous to children and pets, so store and dispose of the patches in a safe place out of their reach.
      • Might not be the best choice if you've had allergic reactions to numbing medications (local anesthetics) in the past.
      • Even though only small amounts of Lidoderm (Lidocaine) are absorbed into the body through the skin, if you're taking medications that treat arrhythmias, Lidoderm (Lidocaine) can affect how they work.
      • Patches shouldn't be left on for more than 12 hours, used on very large areas of skin, or covered with a heating pad.
      • Can cause sleepiness, speech problems, tingling sensations, and weight loss.
      • A few people will get kidney stones.
      • Not safe to use if you're pregnant.
      Tips from our pharmacists for people taking the medication
      • Starts working with the first dose, but full effects can take longer.
      • Remove the protective lining on the patch before applying the patch to unbroken skin.
      • Leave the patch on for up to 12 hours during a 24 hour period.
      • You can cut the patches to create a custom fit for the area of skin you need to apply it to.
      • Don't place any tight wraps or heating pads over the patch while it's on.
      • Make sure not to touch your eyes after touching the patch. Always wash your hands after putting it on or taking it off.
      • For the first week, avoid activities that require you to be alert.
      • Don't use if pregnant.
      • Can cause tingling skin sensations and reduced appetite.
      • Report any confusion, decreased sweating, fever, or changes in behavior or vision.
      • Takes 3 to 4 weeks to feel full effects on mood.
      Learn more
      More about LidocaineSide effectsReviews & ratingsAlternativesFDA package insert
      More about TopamaxSide effectsReviews & ratingsAlternativesFDA package insert