Compare chlordiazepoxide / amitriptyline vs. Anafranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats anxiety and depression.

While Limbitrol (chlordiazepoxide / amitriptyline) as a combination can be used to treat both anxiety and depression, other medicines are considered first choice because chlordiazepoxide can be potentially addicting.

Helps with your actions.

Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.

Upsides
  • Limbitrol (chlordiazepoxide / amitriptyline) is available as a generic.
  • Limbitrol (chlordiazepoxide / amitriptyline) works faster than amitriptyline alone.
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
Downsides
  • Limbitrol (chlordiazepoxide / amitriptyline) is only available in certain strengths, so it can be difficult to customize a dose that treats both anxiety and depression.
  • Limbitrol (chlordiazepoxide / amitriptyline) contains chlordiazepoxide, which can be potentially addicting.
  • You might not notice any changes in your mood until you've been taking Limbitrol (chlordiazepoxide / amitriptyline) for several weeks.
  • Amitriptyline alone is considered a better treatment for anxiety and depression than Limbitrol (chlordiazepoxide / amitriptyline).
  • Other medicines are considered first choice for treating anxiety and depression over Limbitrol (chlordiazepoxide / amitriptyline).
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
Used for
  • Anxiety and depression
Dosage forms
  • Pill
  • Pill
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Reviews
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
The Limbitrol (chlordiazepoxide / amitriptyline) FDA package insert doesn’t have numbers about how common side effects are.
109possible side effects
  • Dry mouth
    84%
  • Somnolence
    54%
  • Tremor
    54%
  • Dizziness
    54%
  • Headache
    52%
  • Constipation
    47%
  • Ejaculation failure
    42%
  • Fatigue
    39%
  • Nausea
    33%
  • Increased sweating
    28%
  • Insomnia
    25%
  • Dyspepsia
    22%
  • Anorexia
    22%
  • Libido change
    21%
  • Any side effect
    20%
  • Impotence
    20%
  • Nervousness
    18%
  • Weight increase
    18%
  • Abnormal vision
    18%
  • Pharyngitis
    14%
  • Micturition disorder
    14%
  • Myoclonus
    13%
  • Diarrhea
    13%
  • Myalgia
    13%
  • Abdominal pain
    13%
  • Rhinitis
    12%
  • Dysmenorrhea
    12%
  • Increased appetite
    11%
  • Digestive system complaints, mainly nausea and vomiting
    10%
  • Paresthesia
    9%
  • Memory impairment
    9%
  • Anxiety
    9%
  • Sleep disorder
    9%
  • Rash
    8%
  • Flushing
    8%
  • Taste perversion
    8%
  • Twitching
    7%
  • Vomiting
    7%
  • Chest pain
    7%
  • Allergy
    7%
  • Weight decrease
    7%
  • Bronchospasm
    7%
  • Urinary retention
    7%
  • Pruritus
    6%
  • Flatulence
    6%
  • Postural hypotension
    6%
  • Sinusitis
    6%
  • Coughing
    6%
  • Urinary tract infection
    6%
  • Tinnitus
    6%
  • Back pain
    6%
  • Nervous system complaints, mainly somnolence
    5%
  • Impaired concentration
    5%
  • Depression
    5%
  • Tooth disorder
    5%
  • Hot flushes
    5%
  • Micturition frequency
    5%
  • Hypertonia
    4%
  • Fever
    4%
  • Palpitation
    4%
  • Tachycardia
    4%
  • Lactation (nonpuerperal)
    4%
  • Menstrual disorder
    4%
  • Pain
    4%
  • Otitis media
    4%
  • Psychosomatic disorder
    3%
  • Yawning
    3%
  • Confusion
    3%
  • Speech disorder
    3%
  • Abnormal dreaming
    3%
  • Agitation
    3%
  • Migraine
    3%
  • Abnormal lacrimation
    3%
  • Arthralgia
    3%
  • Depersonalization
    2%
  • Irritability
    2%
  • Emotional lability
    2%
  • Dermatitis
    2%
  • Acne
    2%
  • Dry skin
    2%
  • Gastrointestinal disorder
    2%
  • Dysphagia
    2%
  • Local edema
    2%
  • Chills
    2%
  • Epistaxis
    2%
  • Dysuria
    2%
  • Cystitis
    2%
  • Vaginitis
    2%
  • Leukorrhea
    2%
  • Breast enlargement
    2%
  • Mydriasis
    2%
  • Thirst
    2%
  • Panic reaction
    2%
  • Aggressive reaction
    2%
  • Paresis
    2%
  • Abnormal skin odor
    2%
  • Eructation
    2%
  • Ulcerative stomatitis
    2%
  • Asthenia
    2%
  • Halitosis
    2%
  • Syncope
    2%
  • Dyspnea
    2%
  • Laryngitis
    2%
  • Anisocoria
    2%
  • Blepharospasm
    2%
  • Ocular allergy
    2%
  • Vestibular disorder
    2%
  • Muscle weakness
    2%
  • Anemia
    2%
See more detailed side effects
Risks and risk factors
  • Higher risk of suicide
    • People under age 24
  • Breathing problems
  • Possible bipolar disorder
  • Vision changes
    • Glaucoma
  • Changes in heartbeat, heart attack, or stroke
    • Heart disease
  • Breathing problems
    • Alcohol
    • Taking narcotics, tranquilizers, or antihistamines
  • Drowsiness and sleepiness
    • Drinking alcohol or taking narcotics
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Seizure
    • History of seizure
    • Taking other medicines that increase seizure risk
    • Alcoholism
  • Withdrawal
    • Stopping Anafranil (Clomipramine) suddenly
  • Low blood pressure
    • Age 65 years or older
  • Heart problems
    • History of heart disease
    • Older age
    • Electrolyte imbalance
See more detailed risks and warnings