Compare chlordiazepoxide / amitriptyline vs. Anafranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Limbitrol
(chlordiazepoxide / amitriptyline)

Anafranil
(clomipramine)

Treats anxiety and depression. While Limbitrol (chlordiazepoxide / amitriptyline) as a combination can be used to treat both anxiety and depression, other medicines are considered first choice because chlordiazepoxide can be potentially addicting.Helps with your actions. Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.
Reviews & ratings
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Have you used Limbitrol (chlordiazepoxide / amitriptyline)?
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Side effects
chlordiazepoxide / amitriptylineAnafranil

The chlordiazepoxide / amitriptyline FDA package insert doesn’t have numbers about how common side effects are.

More about chlordiazepoxide / amitriptyline side effects »
  • Dry mouth 67%
  • Tremor 52%
  • Dizziness 40%
  • Drowsiness 38%
  • Headache 11%
  • Constipation 36%
  • Ejaculation failure 40%
  • Fatigue 21%
More Anafranil side effects »
How it works
chlordiazepoxide / amitriptylineAnafranil
Limbitrol (chlordiazepoxide / amitriptyline) is a combination of 2 medicines. Chlordiazepoxide is a benzodiazepine, and it calms activity in a part of the brain responsible for emotional responses. Amitriptyline is a tricyclic antidepressant, and it raises the amount of norepinephrine and serotonin in the brain, which can improve mood.Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.
Type of medication
chlordiazepoxide / amitriptylineAnafranil
Prescription onlyPrescription only
Available as
chlordiazepoxide / amitriptylineAnafranil
  • Pill
  • Pill
Used for
chlordiazepoxide / amitriptylineAnafranil
  • Anxiety And Depression
Risk factors for serious side effects
chlordiazepoxide / amitriptylineAnafranil
  • People under age 24
  • Glaucoma
  • Heart disease
  • Alcohol
  • Taking narcotics, tranquilizers, or antihistamines
Detailed Limbitrol (chlordiazepoxide / amitriptyline) risks & warnings »
  • Age 24 years or younger
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Using other medications that affect serotonin
  • History of seizure
Detailed Anafranil (clomipramine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
chlordiazepoxide / amitriptylineAnafranil
  • Don't drink alcohol or take narcotics, tranquilizers, or antihistamines if you're taking Limbitrol (chlordiazepoxide / amitriptyline). This can slow down your breathing. Talk to your doctor if this is a problem.
  • Don't drink alcohol or take any narcotics while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can slow your breathing.
No alcohol related info.
Food
chlordiazepoxide / amitriptylineAnafranil
No food related info.
  • Take it with food and/or at bedtime to decrease the potential side effects.
Sleep
chlordiazepoxide / amitriptylineAnafranil
  • Limbitrol (chlordiazepoxide / amitriptyline) can make you sleepy and unable to focus, so don't drive or do anything requiring concentration for a few hours after taking it until you know how it affects you. This can be worse if you drink alcohol or take narcotics.
  • Can help you sleep.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
Upsides and benefits
chlordiazepoxide / amitriptylineAnafranil
  • Limbitrol (chlordiazepoxide / amitriptyline) is available as a generic.
  • Limbitrol (chlordiazepoxide / amitriptyline) works faster than amitriptyline alone.
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
Downsides and risks
chlordiazepoxide / amitriptylineAnafranil
  • Limbitrol (chlordiazepoxide / amitriptyline) is only available in certain strengths, so it can be difficult to customize a dose that treats both anxiety and depression.
  • Limbitrol (chlordiazepoxide / amitriptyline) contains chlordiazepoxide, which can be potentially addicting.
  • You might not notice any changes in your mood until you've been taking Limbitrol (chlordiazepoxide / amitriptyline) for several weeks.
  • Amitriptyline alone is considered a better treatment for anxiety and depression than Limbitrol (chlordiazepoxide / amitriptyline).
  • Other medicines are considered first choice for treating anxiety and depression over Limbitrol (chlordiazepoxide / amitriptyline).
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
Tips from our pharmacists for people taking the medication
chlordiazepoxide / amitriptylineAnafranil
  • Don't drink alcohol or take any narcotics while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can slow your breathing.
  • If you've taken Limbitrol (chlordiazepoxide / amitriptyline) for an extended amount of time, don't stop taking it suddenly without talking to your doctor first. It can be very dangerous.
  • Don't drive or do anything requiring concentration while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can make you sleepy. This can be worse if you drink alcohol or take narcotics.
  • You might not notice changes in your mood until you've taken Limbitrol (chlordiazepoxide / amitriptyline) for at least a few weeks.
  • If you're being switched to Limbitrol (chlordiazepoxide / amitriptyline) from a group of medicines called monoamine oxidase inhibitors (MAOI), you should wait at least 14 days before you start.
  • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
  • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
Learn more
More about chlordiazepoxide / amitriptylineSide effectsAlternativesFDA package insert
Have you used Limbitrol (chlordiazepoxide / amitriptyline)?
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More about AnafranilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Anafranil (clomipramine)?
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