Compare chlordiazepoxide / amitriptyline vs. desipramine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Limbitrol
(chlordiazepoxide / amitriptyline)

Norpramin
(desipramine)

Treats anxiety and depression. While Limbitrol (chlordiazepoxide / amitriptyline) as a combination can be used to treat both anxiety and depression, other medicines are considered first choice because chlordiazepoxide can be potentially addicting.Stabilizes your mood. Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Best available price for 30 (10mg/25mg) tablets of chlordiazepoxide / amitriptyline
Coupons for desipramine
Best available price for 30 (25mg) tablets of desipramine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Limbitrol (chlordiazepoxide / amitriptyline)
Not enough review data. Review it!
of people (All ages) say Limbitrol (chlordiazepoxide / amitriptyline) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Limbitrol (chlordiazepoxide / amitriptyline)?
Worth itNot sureNot worth it
Reviews for Norpramin (desipramine)
Not enough review data. Review it!
Same vs. Limbitrol (chlordiazepoxide / amitriptyline)
Not enough review data. Review it!
Same vs. Limbitrol (chlordiazepoxide / amitriptyline)
Not enough review data. Review it!
Same vs. Limbitrol (chlordiazepoxide / amitriptyline)
Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it
Side effects
chlordiazepoxide / amitriptylinedesipramine

The chlordiazepoxide / amitriptyline FDA package insert doesn’t have numbers about how common side effects are.

More about chlordiazepoxide / amitriptyline side effects »

The desipramine FDA package insert doesn’t have numbers about how common side effects are.

More about desipramine side effects »
How it works
chlordiazepoxide / amitriptylinedesipramine
Limbitrol (chlordiazepoxide / amitriptyline) is a combination of 2 medicines. Chlordiazepoxide is a benzodiazepine, and it calms activity in a part of the brain responsible for emotional responses. Amitriptyline is a tricyclic antidepressant, and it raises the amount of norepinephrine and serotonin in the brain, which can improve mood.Norpramin (desipramine) is a tricyclic antidepressant. It increases the amount of norepinephrine and serotonin in the brain, two chemicals that regulate mood.
Type of medication
chlordiazepoxide / amitriptylinedesipramine
Prescription only
Prescription only
Available as
chlordiazepoxide / amitriptylinedesipramine
  • Pill
  • Pill
Used for
chlordiazepoxide / amitriptylinedesipramine
  • Anxiety And Depression
Risk factors for serious side effects
chlordiazepoxide / amitriptylinedesipramine
  • People under age 24
  • Glaucoma
  • Heart disease
  • Alcohol
  • Taking narcotics, tranquilizers, or antihistamines
Detailed Limbitrol (chlordiazepoxide / amitriptyline) risks & warnings »
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Norpramin (desipramine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
chlordiazepoxide / amitriptylinedesipramine
  • Don't drink alcohol or take any narcotics while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can slow your breathing.
  • Don't drink alcohol or take narcotics, tranquilizers, or antihistamines if you're taking Limbitrol (chlordiazepoxide / amitriptyline). This can slow down your breathing. Talk to your doctor if this is a problem.
No alcohol related info.
Sleep
chlordiazepoxide / amitriptylinedesipramine
  • Limbitrol (chlordiazepoxide / amitriptyline) can make you sleepy and unable to focus, so don't drive or do anything requiring concentration for a few hours after taking it until you know how it affects you. This can be worse if you drink alcohol or take narcotics.
No sleep related info.
Upsides and benefits
chlordiazepoxide / amitriptylinedesipramine
  • Limbitrol (chlordiazepoxide / amitriptyline) is available as a generic.
  • Limbitrol (chlordiazepoxide / amitriptyline) works faster than amitriptyline alone.
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
Downsides and risks
chlordiazepoxide / amitriptylinedesipramine
  • Limbitrol (chlordiazepoxide / amitriptyline) is only available in certain strengths, so it can be difficult to customize a dose that treats both anxiety and depression.
  • Limbitrol (chlordiazepoxide / amitriptyline) contains chlordiazepoxide, which can be potentially addicting.
  • You might not notice any changes in your mood until you've been taking Limbitrol (chlordiazepoxide / amitriptyline) for several weeks.
  • Amitriptyline alone is considered a better treatment for anxiety and depression than Limbitrol (chlordiazepoxide / amitriptyline).
  • Other medicines are considered first choice for treating anxiety and depression over Limbitrol (chlordiazepoxide / amitriptyline).
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
Tips from our pharmacists for people taking the medication
chlordiazepoxide / amitriptylinedesipramine
  • Don't drink alcohol or take any narcotics while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can slow your breathing.
  • If you've taken Limbitrol (chlordiazepoxide / amitriptyline) for an extended amount of time, don't stop taking it suddenly without talking to your doctor first. It can be very dangerous.
  • Don't drive or do anything requiring concentration while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can make you sleepy. This can be worse if you drink alcohol or take narcotics.
  • You might not notice changes in your mood until you've taken Limbitrol (chlordiazepoxide / amitriptyline) for at least a few weeks.
  • If you're being switched to Limbitrol (chlordiazepoxide / amitriptyline) from a group of medicines called monoamine oxidase inhibitors (MAOI), you should wait at least 14 days before you start.
  • Don't drive or do anything requiring concentration until you know how Norpramin (desipramine) affects you since it can make you feel sleepy.
  • Talk to your doctor right away if your mood suddenly darkens and you want to hurt yourself while taking Norpramin (desipramine).
  • If you're being switched to Norpramin (desipramine) from monoamine oxidase inhibitors, you'll need to wait 2 weeks before you can start it.
  • Don't stop taking Norpramin (desipramine) suddenly without talking to your doctor first.
Learn more
More about chlordiazepoxide / amitriptylineSide effectsAlternativesFDA package insert
Have you used Limbitrol (chlordiazepoxide / amitriptyline)?
Worth itNot sureNot worth it
More about desipramineSide effectsAlternativesFDA package insert
Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it