Compare Lisinopril vs. Aldactone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(Lisinopril)

Aldactone
(Spironolactone)

Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Removes extra water from your body. Aldactone (Spironolactone) is helpful when added to another diuretic to get rid of excess fluid in your body. Doesn't work well on its own.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.164201183431953Lisinopril
Reviews for Zestril (Lisinopril)
61%
of people say Zestril (Lisinopril) is worth it
51%
say it works well
13%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
LisinoprilAldactone
  • Dizziness 7%
  • Headache 4%
  • Cough 3%
  • Diarrhea 2%
  • Chest pain 2%
  • Fatigue 2%
  • Upper respiratory infection 1%
More Lisinopril side effects »

We haven’t found good data for Aldactone side effects.

FDA side effect reports for Aldactone »
How it works
LisinoprilAldactone
Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Aldactone (Spironolactone) is a potassium-sparing diuretic that blocks aldosterone (a hormone) and helps the kidney get rid of excess fluids in your body.
Type of medication
LisinoprilAldactone
Antihypertensive
ACE inhibitor
Prescription only
Antihypertensive
Diuretic
Prescription only
Available as
LisinoprilAldactone
  • Pill
  • Pill
Used for (click to learn more)
LisinoprilAldactone
Risk factors for serious side effects
LisinoprilAldactone
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Zestril (Lisinopril) risks & warnings »
      • Taking with alcohol
      • Taking other medicines that make you less alert
      • Current kidney problems
      • Medicine that increase potassium
      • Use of salt substitute
        Detailed Aldactone (Spironolactone) risks & warnings »
        Pregnancy category
        LisinoprilAldactone
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
        • Requires routine blood tests to check kidney function.
        • Needs to have blood tests done to monitor electrolyte levels and kidney function.
        • Aldactone (Spironolactone) can increase the amount of potassium in your body. High potassium can cause heart problems. Baseline and routine blood tests are needed to monitor your potassium and kidney function.
        Sex
        No specific sex-related info.
        • You can have breast pain/swelling, irregular periods (women), or trouble with sexual performance.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        LisinoprilAldactone
        • A first-choice blood pressure treatment for many people.
        • Lowers the risk of heart attack and stroke.
        • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
        • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
        • Has a low risk of causing muscle problems due to low potassium levels in your blood.
        • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
        • Can lower blood pressure.
        • Reduces the risk of death in people with heart failure.
        Downsides and risks
        LisinoprilAldactone
        • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
        • Requires a yearly blood test to see how the medicine is affecting your body.
        • Not safe to use if you're pregnant.
        • Not very good at getting rid of excess fluids on its own. Should be used with another drug to help get rid of excess fluids.
        • Has many possible side effects, especially when higher doses are used.
        • Can increase the risk of tumor growth.
        • Needs to have blood tests done to monitor electrolyte levels and kidney function.
        Tips from our pharmacists for people taking the medication
        LisinoprilAldactone
        • Can cause dizziness in the first few days.
        • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
        • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
        • Requires routine blood tests to check kidney function.
        • Don't take it if you're pregnant.
        • Can make you dizzy or cause trouble concentrating, so be careful using it until you know how the medicine affects you.
        • Don't use supplements or salt substitutes that are high in potassium.
        • You can have breast pain/swelling, irregular periods (women), or trouble with sexual performance.
        • Tell your doctor about any muscle weakness, skin changes, red or black tarry stool.
        • Can take 2 to 3 days to see full diuretic effects and 2 to 3 weeks to see blood pressure lowering effects.
        Learn more
        More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
        More about AldactoneSide effectsReviews & ratingsAlternativesFDA package insert