Compare Lisinopril vs. spironolactone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril (lisinopril)

Prescription only
Lowers blood pressure.

Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.

5.2/ 7 average rating with 687 reviewsforLisinopril
Removes extra water from your body.

Aldactone (spironolactone) should be used with other medicines to get rid of excess fluid in your body, especially if you have heart failure.

Upsides
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Very cheap drug, and comes available as a liquid for children over 6 years of age.
  • Has a low risk of causing muscle problems from low potassium levels in your blood.
  • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
  • Can lower blood pressure.
  • Reduces the risk of death in people with heart failure.
Downsides
  • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Zestril (lisinopril) isn't safe to use if you're pregnant.
  • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
  • Aldactone (spironolactone) doesn't work well on its own. It should be used with another drug to help get rid of excess fluids.
  • Has many possible side effects, especially when higher doses are used.
  • Can increase the risk of tumor growth.
  • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price near you
$4
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Lowest price near you
$4
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Reviews
687 
61%
think this treatment is worth it
51%
think this treatment works well
14%
think this treatment is a hassle

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Side effects
1possible side effects
  • Low blood pressure
    5%
See more detailed side effects
The Aldactone (spironolactone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Harm to fetus

    Women of childbearing age

  • Swelling of face and head

    African descent

  • High potassium

    Current kidney problems

    ...and 2 more risk factors

  • Worsening kidney problems

    History of kidney problems

  • Low blood pressure

    Taking with alcohol

    ...and 1 more risk factors

See more detailed risks and warnings
  • Low blood pressure

    Taking with alcohol

    ...and 1 more risk factors

  • Heart problems from high potassium

    Current kidney problems

    ...and 2 more risk factors

See more detailed risks and warnings