Compare Lisinopril vs. spironolactone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(lisinopril)

Aldactone
(spironolactone)

Lowers blood pressure. Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Removes extra water from your body. Aldactone (spironolactone) should be used with other medicines to get rid of excess fluid in your body, especially if you have heart failure.
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Prices and coupon for 30 (20mg) tablets of lisinopril
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Prices and coupon for 30 (25mg) tablets of spironolactone
Reviews & ratings
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5.17Lisinopril
Reviews for Zestril (lisinopril)
61%
of people (All ages) say Zestril (lisinopril) is worth it
51%
say it works well
14%
say it's a big hassle
687 reviews
Have you used Zestril (lisinopril)?
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Have you used Aldactone (spironolactone)?
Worth itNot sureNot worth it
Side effects
Lisinoprilspironolactone
  • Headache 4%
  • Dizziness 4%
  • Cough 3%
  • Low blood pressure 4%
  • Chest pain 2%
  • Kidney damage 10%
  • Fainting 7%
  • High potassium 6%
More Lisinopril side effects »

The spironolactone FDA package insert doesn’t have numbers about how common side effects are.

More about spironolactone side effects »
How it works
Lisinoprilspironolactone
Zestril (lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Aldactone (spironolactone) is a potassium-sparing diuretic that blocks aldosterone (a hormone) and helps the kidney get rid of excess fluids in your body.
Type of medication
Lisinoprilspironolactone
Prescription only
Prescription only
Available as
Lisinoprilspironolactone
  • Pill
  • Liquid
  • Pill
Used for
Lisinoprilspironolactone
Risk factors for serious side effects
Lisinoprilspironolactone
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicines that increase potassium
    • Use of salt substitutes
    • History of kidney problems
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
    Detailed Zestril (lisinopril) risks & warnings »
      • Taking with alcohol
      • Taking other medicines that lower your blood pressure
      • Current kidney problems
      • Taking other medicines that increase potassium
      • Use of salt substitutes
        Detailed Aldactone (spironolactone) risks & warnings »
        Pregnancy

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Kidneys and liver
        Lisinoprilspironolactone
        • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
        • You'll need to have blood tests done to check your kidney function.
        • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
        Pain
        Lisinoprilspironolactone
        No pain related info.
        • It can cause breast pain/swelling, irregular periods (women), or trouble with sexual performance.
        Upsides and benefits
        Lisinoprilspironolactone
        • A first-choice blood pressure treatment for many people.
        • Lowers the risk of heart attack and stroke.
        • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
        • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
        • Very cheap drug, and comes available as a liquid for children over 6 years of age.
        • Has a low risk of causing muscle problems from low potassium levels in your blood.
        • More useful when taken with another diuretic that'll also help your body get rid of extra fluids.
        • Can lower blood pressure.
        • Reduces the risk of death in people with heart failure.
        Downsides and risks
        Lisinoprilspironolactone
        • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
        • Requires a yearly blood test to see how the medicine is affecting your body.
        • Zestril (lisinopril) isn't safe to use if you're pregnant.
        • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
        • Aldactone (spironolactone) doesn't work well on its own. It should be used with another drug to help get rid of excess fluids.
        • Has many possible side effects, especially when higher doses are used.
        • Can increase the risk of tumor growth.
        • You'll need to have blood tests done regularly since Aldactone (spironolactone) can affect your potassium levels and kidneys.
        Tips from our pharmacists for people taking the medication
        Lisinoprilspironolactone
        • Can cause dizziness the first few days you're taking it.
        • Check your blood pressure about 1 week after starting Zestril (lisinopril), and tell your doctor if it hasn't improved.
        • Let your doctor know about any dizziness, tiredness, cough, or throat irritation that doesn't go away.
        • You'll need to have blood tests done to check your kidney function.
        • Don't take Zestril (lisinopril) if you're pregnant.
        • Can make you dizzy or cause trouble concentrating, so be careful using it until you know how the medicine affects you.
        • Don't use supplements or salt substitutes that are high in potassium.
        • It can cause breast pain/swelling, irregular periods (women), or trouble with sexual performance.
        • Tell your doctor about any muscle weakness, skin changes, and red or black tarry stool.
        • You will urinate more often within 2 to 3 days, and will have lower blood pressure in 2 to 3 weeks.
        Learn more
        More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Zestril (lisinopril)?
        Worth itNot sureNot worth it
        More about spironolactoneSide effectsAlternativesFDA package insert
        Have you used Aldactone (spironolactone)?
        Worth itNot sureNot worth it