Compare Lisinopril vs. Avapro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(lisinopril)

Avapro
(irbesartan)

Lowers blood pressure. Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Avapro (irbesartan) is a good blood pressure-lowering medicine that protects your kidneys and has few side effects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.17Lisinopril
Reviews for Lisinopril
61%
of people (All ages) say Lisinopril is worth it
51%
say it works well
14%
say it's a big hassle
687 reviews
Have you used Zestril (lisinopril)?
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Have you used Avapro (irbesartan)?
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Side effects
LisinoprilAvapro
  • Headache 4%
  • Dizziness 4%
  • Cough 3%
  • Low blood pressure 4%
  • Chest pain 2%
  • Kidney damage 10%
  • Fainting 7%
  • High potassium 6%
More Lisinopril side effects »
  • Fatigue 1%
  • Diarrhea 1%
  • Heartburn 1%
More Avapro side effects »
How it works
LisinoprilAvapro
Zestril (lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Avapro (irbesartan) is an angiotensin receptor blocker (ARB). It lowers blood pressure by blocking a chemical that tightens the blood vessels. This allows more blood and oxygen to get to your heart and other organs.
Type of medication
LisinoprilAvapro
Prescription onlyPrescription only
Available as
LisinoprilAvapro
  • Pill
  • Liquid
  • Pill
Used for
LisinoprilAvapro
Risk factors for serious side effects
LisinoprilAvapro
  • Women of childbearing age
  • African descent
  • Current kidney problems
  • Medicines that increase potassium
  • Use of salt substitutes
Detailed Zestril (lisinopril) risks & warnings »
  • Women of childbearing age
  • History of kidney problems
  • African descent
  • Current kidney problems
  • Using medicines that increase potassium
Detailed Avapro (irbesartan) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
LisinoprilAvapro
  • You'll need to have blood tests done to check your kidney function.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Avapro (irbesartan) can hurt your kidneys. If you already have kidney damage, Avapro (irbesartan) could make it worse. Your doctor will do regular blood tests to check your kidneys, usually before you start Avapro (irbesartan), and at least once a year while you're still on it.
  • You'll need to have blood tests done regularly since Avapro (irbesartan) can affect your kidneys and potassium levels.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
Upsides and benefits
LisinoprilAvapro
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Very cheap drug, and comes available as a liquid for children over 6 years of age.
  • Avapro (irbesartan) lowers your risk of heart attack and stroke.
  • It works similar to ACE inhibitors (like lisinopril), but it doesn't have the same side effects like coughing and facial swelling.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • It's recommended for people with heart failure since it lowers the risk of death and further damage to your heart.
  • Available in generic, and available with hydrochlorothiazide as a combination tablet.
Downsides and risks
LisinoprilAvapro
  • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Zestril (lisinopril) isn't safe to use if you're pregnant.
  • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
  • You'll need to get yearly blood tests while taking Avapro (irbesartan) to see how it is affecting your body.
  • It's not safe to use Avapro (irbesartan) if you're pregnant.
  • Avapro (irbesartan) can cause the level of potassium in your blood to go up.
  • You'll need to get medical help if you notice any unusual swelling around your head and neck.
  • Can't be used in children under 18.
Tips from our pharmacists for people taking the medication
LisinoprilAvapro
  • Can cause dizziness the first few days you're taking it.
  • Check your blood pressure about 1 week after starting Zestril (lisinopril), and tell your doctor if it hasn't improved.
  • Let your doctor know about any dizziness, tiredness, cough, or throat irritation that doesn't go away.
  • You'll need to have blood tests done to check your kidney function.
  • Don't take Zestril (lisinopril) if you're pregnant.
  • Avapro (irbesartan) can make you feel a little dizzy for the first few days.
  • You'll need to have blood tests done regularly since Avapro (irbesartan) can affect your kidneys and potassium levels.
  • Don't eat a lot of foods that are high in potassium or use salt substitutes that contain potassium.
  • Tell your doctor about any dizziness or muscle weakness that doesn't go away after the first few days.
  • Don't take Avapro (irbesartan) if you're pregnant.
Learn more
More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zestril (lisinopril)?
Worth itNot sureNot worth it
More about AvaproSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Avapro (irbesartan)?
Worth itNot sureNot worth it