Compare Lisinopril vs. Benicar

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(Lisinopril)

Benicar
(Olmesartan)

Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Benicar (Olmesartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.164201183431953Lisinopril
Reviews for Zestril (Lisinopril)
61%
of people say Zestril (Lisinopril) is worth it
51%
say it works well
13%
say it's a big hassle
Reviews for Benicar (Olmesartan)
66%
+5% vs. Zestril (Lisinopril)
63%
+12% vs. Zestril (Lisinopril)
13%
Same vs. Zestril (Lisinopril)
Side effects
LisinoprilBenicar
  • Dizziness 7%
  • Headache 4%
  • Cough 3%
  • Diarrhea 2%
  • Chest pain 2%
  • Fatigue 2%
  • Upper respiratory infection 1%
More Lisinopril side effects »
  • Dizziness 2%
More Benicar side effects »
How it works
LisinoprilBenicar
Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Benicar (Olmesartan) is an angiotensin receptor blocker (ARB). It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
Type of medication
LisinoprilBenicar
Antihypertensive
ACE inhibitor
Prescription only
Antihypertensive
Angiotensin receptor blocker
Prescription only
Available as
LisinoprilBenicar
  • Pill
  • Pill
Used for (click to learn more)
LisinoprilBenicar
Risk factors for serious side effects
LisinoprilBenicar
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Zestril (Lisinopril) risks & warnings »
      • African descent
      • Current kidney problems
      • Medicine that increase potassium
      • Use of salt substitute
        Detailed Benicar (Olmesartan) risks & warnings »
        Pregnancy category
        LisinoprilBenicar
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
        • Requires routine blood tests to check kidney function.
        • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
        • Requires routine blood tests to check kidney function.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.
        • Benicar (Olmesartan) has been reported to cause severe diarrhea and weight loss unexplained by other causes. Stay hydrated and notify your doctor if you continue to have more than 3-4 loose stools a day.
        Upsides and benefits
        LisinoprilBenicar
        • A first-choice blood pressure treatment for many people.
        • Lowers the risk of heart attack and stroke.
        • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
        • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
        • Similar to ACE inhibitors (like Lisinopril), with fewer side effects like cough and swelling.
        • A first-choice blood pressure treatment for many people.
        • Lowers the risk of heart attack and stroke.
        • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
        • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
        Downsides and risks
        LisinoprilBenicar
        • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
        • Requires a yearly blood test to see how the medicine is affecting your body.
        • Not safe to use if you're pregnant.
        • Not available in less expensive generic form.
        • Requires a yearly blood test to see how the medicine is affecting your body.
        • Not safe to use if you're pregnant.
        Tips from our pharmacists for people taking the medication
        LisinoprilBenicar
        • Can cause dizziness in the first few days.
        • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
        • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
        • Requires routine blood tests to check kidney function.
        • Don't take it if you're pregnant.
        • Can cause dizziness in the first few days.
        • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
        • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
        • Requires routine blood tests to check kidney function.
        • Don't take it if you're pregnant.
        Learn more
        More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
        More about BenicarSide effectsReviews & ratingsAlternativesFDA package insert