Compare Lisinopril vs. Benicar

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(lisinopril)

Benicar
(olmesartan)

Lowers blood pressure. Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Benicar (Olmesartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.
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Prices and coupon for 30 (20mg) tablets of lisinopril
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Prices and coupon for 30 (20mg) tablets of olmesartan
Reviews & ratings
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Filter group. All currently selected
5.17Lisinopril
Reviews for Zestril (lisinopril)
61%
of people (All ages) say Zestril (lisinopril) is worth it
51%
say it works well
14%
say it's a big hassle
687 reviews
Have you used Zestril (lisinopril)?
Worth itNot sureNot worth it
Reviews for Benicar (olmesartan)
65%
+4% better vs. Zestril (lisinopril)
63%
+12% better vs. Zestril (lisinopril)
12%
+2% better vs. Zestril (lisinopril)
118 reviews
Have you used Benicar (olmesartan)?
Worth itNot sureNot worth it
Side effects
LisinoprilBenicar
  • Headache 4%
  • Dizziness 4%
  • Cough 3%
  • Low blood pressure 4%
  • Chest pain 2%
  • Kidney damage 10%
  • Fainting 7%
  • High potassium 6%
More Lisinopril side effects »
  • Dizziness 2%
More Benicar side effects »
How it works
LisinoprilBenicar
Zestril (lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Benicar (Olmesartan) is an angiotensin receptor blocker (ARB). It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
Type of medication
LisinoprilBenicar
Prescription only
Prescription only
Available as
LisinoprilBenicar
  • Pill
  • Liquid
  • Pill
Used for
LisinoprilBenicar
Risk factors for serious side effects
LisinoprilBenicar
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicines that increase potassium
    • Use of salt substitutes
    • History of kidney problems
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
    Detailed Zestril (lisinopril) risks & warnings »
      • African descent
      • Current kidney problems
      • Medicine that increase potassium
      • Use of salt substitute
        Detailed Benicar (olmesartan) risks & warnings »
        Pregnancy

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Kidneys and liver
        LisinoprilBenicar
        • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
        • You'll need to have blood tests done to check your kidney function.
        • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
        • Requires routine blood tests to check kidney function.
        Weight
        LisinoprilBenicar
        No weight related info.
        • Benicar (Olmesartan) has been reported to cause severe diarrhea and weight loss unexplained by other causes. Stay hydrated and notify your doctor if you continue to have more than 3-4 loose stools a day.
        Upsides and benefits
        LisinoprilBenicar
        • A first-choice blood pressure treatment for many people.
        • Lowers the risk of heart attack and stroke.
        • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
        • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
        • Very cheap drug, and comes available as a liquid for children over 6 years of age.
        • A first-choice blood pressure treatment for many people.
        • Lowers the risk of heart attack and stroke.
        • Similar to ACE inhibitors (like Lisinopril), with fewer side effects like cough and swelling.
        • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
        • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
        Downsides and risks
        LisinoprilBenicar
        • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
        • Requires a yearly blood test to see how the medicine is affecting your body.
        • Zestril (lisinopril) isn't safe to use if you're pregnant.
        • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
        • Requires a yearly blood test to see how the medicine is affecting your body.
        • Not safe to use if you're pregnant.
        • Not available in less expensive generic form.
        Tips from our pharmacists for people taking the medication
        LisinoprilBenicar
        • Can cause dizziness the first few days you're taking it.
        • Check your blood pressure about 1 week after starting Zestril (lisinopril), and tell your doctor if it hasn't improved.
        • Let your doctor know about any dizziness, tiredness, cough, or throat irritation that doesn't go away.
        • You'll need to have blood tests done to check your kidney function.
        • Don't take Zestril (lisinopril) if you're pregnant.
        • Can cause dizziness in the first few days.
        • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
        • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
        • Requires routine blood tests to check kidney function.
        • Don't take it if you're pregnant.
        Learn more
        More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Zestril (lisinopril)?
        Worth itNot sureNot worth it
        More about BenicarSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Benicar (olmesartan)?
        Worth itNot sureNot worth it