Compare Lisinopril vs. Bisoprolol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(lisinopril)

Zebeta
(bisoprolol)

Lowers blood pressure. Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Zebeta (Bisoprolol) is usually given to people who have taken other blood pressure meds unsuccessfully or have recently had significant heart problems.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.17Lisinopril
Reviews for Lisinopril
61%
of people (All ages) say Lisinopril is worth it
51%
say it works well
14%
say it's a big hassle
687 reviews
Have you used Zestril (lisinopril)?
Worth itNot sureNot worth it
Reviews for Bisoprolol
67%
-6% worse vs. Lisinopril
61%
-10% worse vs. Lisinopril
28%
+14% better vs. Lisinopril
Have you used Zebeta (bisoprolol)?
Worth itNot sureNot worth it
Side effects
LisinoprilBisoprolol
  • Headache 4%
  • Dizziness 4%
  • Cough 3%
  • Low blood pressure 4%
  • Chest pain 2%
  • Kidney damage 10%
  • Fainting 7%
  • High potassium 6%
More Lisinopril side effects »

We haven’t found good data for Bisoprolol side effects.

FDA side effect reports for Bisoprolol »
How it works
LisinoprilBisoprolol
Zestril (lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Zebeta (Bisoprolol) is a selective beta blocker that works specifically on the heart. It lowers blood pressure by slowing down the heart and making it work less to pump.
Type of medication
LisinoprilBisoprolol
Prescription onlyPrescription only
Available as
LisinoprilBisoprolol
  • Pill
  • Liquid
  • Pill
Used for
LisinoprilBisoprolol
Risk factors for serious side effects
LisinoprilBisoprolol
  • Women of childbearing age
  • African descent
  • Current kidney problems
  • Medicines that increase potassium
  • Use of salt substitutes
Detailed Zestril (lisinopril) risks & warnings »
  • Diabetes
  • Coronary artery disease
  • Heart failure
  • Major surgery requiring anesthesia
Detailed Zebeta (bisoprolol) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
LisinoprilBisoprolol
  • You'll need to have blood tests done to check your kidney function.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
No kidneys and liver related info.
Upsides and benefits
LisinoprilBisoprolol
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Very cheap drug, and comes available as a liquid for children over 6 years of age.
  • Good for protecting the heart and lowering blood pressure if you've had a heart attack.
  • Available in a generic version.
  • Also comes in combination with other medications to lower blood pressure.
Downsides and risks
LisinoprilBisoprolol
  • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Zestril (lisinopril) isn't safe to use if you're pregnant.
  • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
  • This isn't a first choice medication to lower blood pressure.
  • You can't stop taking it suddenly, or else you're more likely to have a heart attack or other problems with your heart.
Tips from our pharmacists for people taking the medication
LisinoprilBisoprolol
  • Can cause dizziness the first few days you're taking it.
  • Check your blood pressure about 1 week after starting Zestril (lisinopril), and tell your doctor if it hasn't improved.
  • Let your doctor know about any dizziness, tiredness, cough, or throat irritation that doesn't go away.
  • You'll need to have blood tests done to check your kidney function.
  • Don't take Zestril (lisinopril) if you're pregnant.
  • Zebeta (Bisoprolol) can make you feel dizzy the first few days you take it, so be careful driving and quickly standing up until you know how your body reacts to it.
  • Don't stop taking it suddenly without talking to your doctor.
  • If you have diabetes, Zebeta (Bisoprolol) can make it difficult to tell if your blood sugar is low.
  • Can cause headache, fatigue, and make you more likely to get colds or the flu.
Learn more
More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zestril (lisinopril)?
Worth itNot sureNot worth it
More about BisoprololSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zebeta (bisoprolol)?
Worth itNot sureNot worth it