Compare Lisinopril vs. Bisoprolol

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Zebeta (Bisoprolol) is usually given to people who have taken other blood pressure meds unsuccessfully or have recently had significant heart problems.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Zestril (Lisinopril)
of people say Zestril (Lisinopril) is worth it
say it works well
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
  • Dizziness 7%
  • Headache 4%
  • Cough 3%
  • Diarrhea 2%
  • Chest pain 2%
  • Fatigue 2%
  • Upper respiratory infection 1%
More Lisinopril side effects »

We haven’t found good data for Bisoprolol side effects.

FDA side effect reports for Bisoprolol »
How it works
Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Zebeta (Bisoprolol) is a selective beta blocker that works specifically on the heart. It lowers blood pressure by slowing down the heart and making it work less to pump.
Type of medication
ACE inhibitor
Prescription only
Beta blocker
Prescription only
Available as
  • Pill
  • Pill
Used for (click to learn more)
Risk factors for serious side effects
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Zestril (Lisinopril) risks & warnings »
    • Diabetes
      • Coronary artery disease
      • Heart failure
      • Major surgery requiring anesthesia
      Detailed Zebeta (Bisoprolol) risks & warnings »
      Pregnancy category
      No specific alcohol-related info.No specific alcohol-related info.
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Requires routine blood tests to check kidney function.
      No specific kidneys and liver-related info.
      No specific sex-related info.No specific sex-related info.
      No specific sleep-related info.No specific sleep-related info.
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      • A first-choice blood pressure treatment for many people.
      • Lowers the risk of heart attack and stroke.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
      • Good for protecting the heart and lowering blood pressure if you've had a heart attack.
      • Available in a generic version.
      • Also comes in combination with other medications to lower blood pressure.
      Downsides and risks
      • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
      • Requires a yearly blood test to see how the medicine is affecting your body.
      • Not safe to use if you're pregnant.
      • This isn't a first choice medication to lower blood pressure.
      • You can't stop taking it suddenly, or else you're more likely to have a heart attack or other problems with your heart.
      Tips from our pharmacists for people taking the medication
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
      • Requires routine blood tests to check kidney function.
      • Don't take it if you're pregnant.
      • Zebeta (Bisoprolol) can make you feel dizzy the first few days you take it, so be careful driving and quickly standing up until you know how your body reacts to it.
      • Don't stop taking it suddenly without talking to your doctor.
      • If you have diabetes, Zebeta (Bisoprolol) can make it difficult to tell if your blood sugar is low.
      • Can cause headache, fatigue, and make you more likely to get colds or the flu.
      Learn more
      More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
      More about BisoprololSide effectsReviews & ratingsAlternativesFDA package insert