Compare Lisinopril vs. Catapres

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(lisinopril)

Catapres
(clonidine)

Lowers blood pressure. Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Catapres (Clonidine) is a good addition if you need more than one medicine to control your blood pressure, but it has a lot of side effects. You can't miss doses.
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Coupons for Lisinopril
Best available price for 30 (20mg) tablets of lisinopril
Coupons for Catapres
Best available price for 60 (0.1mg) tablets of clonidine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.17Lisinopril
Reviews for Lisinopril
61%
of people (All ages) say Lisinopril is worth it
51%
say it works well
14%
say it's a big hassle
687 reviews
Have you used Zestril (lisinopril)?
Worth itNot sureNot worth it
Reviews for Catapres
42%
+19% better vs. Lisinopril
33%
+18% better vs. Lisinopril
35%
+21% better vs. Lisinopril
Have you used Catapres (clonidine)?
Worth itNot sureNot worth it
Side effects
LisinoprilCatapres
  • Headache 4%
  • Dizziness 4%
  • Cough 3%
  • Low blood pressure 4%
  • Chest pain 2%
  • Kidney damage 10%
  • Fainting 7%
  • High potassium 6%
More Lisinopril side effects »
  • Redness/itching / pruritis 26%
  • Dry mouth 25%
  • Drowsiness 12%
  • Skin blistering 7%
  • Fatigue 6%
  • Headache 5%
  • Skin or nail darkening 5%
  • Allergic contact sensitization 5%
  • Burning 3%
  • Lack of energy 3%
More Catapres side effects »
How it works
LisinoprilCatapres
Zestril (lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Catapres (Clonidine) is an alpha-2 agonist. It works in the brain to tell your blood vessels to relax, and it lowers the activity of certain stress hormones. This lowers blood pressure.
Type of medication
LisinoprilCatapres
Prescription onlyPrescription only
Available as
LisinoprilCatapres
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Patch
Used for
LisinoprilCatapres
Risk factors for serious side effects
LisinoprilCatapres
  • Women of childbearing age
  • African descent
  • Current kidney problems
  • Medicines that increase potassium
  • Use of salt substitutes
Detailed Zestril (lisinopril) risks & warnings »
  • Sudden discontinuation of medicine
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 years or older
  • Using other medicine(s) that slows the heart
Detailed Catapres (clonidine) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
LisinoprilCatapres
  • You'll need to have blood tests done to check your kidney function.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
No kidneys and liver related info.
Sleep
LisinoprilCatapres
No sleep related info.
  • Can cause drowsiness, headache, dizziness, and dry mouth.
Upsides and benefits
LisinoprilCatapres
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Very cheap drug, and comes available as a liquid for children over 6 years of age.
  • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
  • Available in a weekly patch for people that aren't good at taking medicine by mouth.
  • Works in the brain, so it can help treat some nervous system and psychiatric conditions.
  • Under the brand name Kapvay, it's used to treat ADHD in children and teenagers.
Downsides and risks
LisinoprilCatapres
  • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Zestril (lisinopril) isn't safe to use if you're pregnant.
  • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
  • Has a lot of side effects compared to other blood pressure-lowering medicine because it works in the brain.
  • The pill form can make some people sleepy, dizzy, and have dry mouth.
  • You can't miss doses. Stopping Clonidine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
Tips from our pharmacists for people taking the medication
LisinoprilCatapres
  • Can cause dizziness the first few days you're taking it.
  • Check your blood pressure about 1 week after starting Zestril (lisinopril), and tell your doctor if it hasn't improved.
  • Let your doctor know about any dizziness, tiredness, cough, or throat irritation that doesn't go away.
  • You'll need to have blood tests done to check your kidney function.
  • Don't take Zestril (lisinopril) if you're pregnant.
  • Usually taken together with other medicines for better blood pressure control.
  • Can cause drowsiness, headache, dizziness, and dry mouth.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • If side effects don't go away, talk to your doctor about alternatives.
  • The weekly patch form can have fewer side effects.
  • Don't stop taking this medicine suddenly.
  • Extended release tablet also used to treat ADHD.
Learn more
More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zestril (lisinopril)?
Worth itNot sureNot worth it
More about CatapresSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Catapres (clonidine)?
Worth itNot sureNot worth it