Compare Lisinopril vs. Digoxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(lisinopril)

Lanoxin
(digoxin)

Lowers blood pressure. Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Improves heart pumping. Digoxin is a good backup for treating heart failure symptoms, but it doesn't, by itself, lower your risk of death.
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Coupons for Lisinopril
Best available price for 30 (20mg) tablets of lisinopril
Coupons for Digoxin
Best available price for 30 (125mcg) tablets of digoxin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.17Lisinopril
Reviews for Zestril (lisinopril)
61%
of people (All ages) say Zestril (lisinopril) is worth it
51%
say it works well
14%
say it's a big hassle
687 reviews
Have you used Zestril (lisinopril)?
Worth itNot sureNot worth it
Reviews for Lanoxin (digoxin)
64%
+3% better vs. Zestril (lisinopril)
43%
-8% worse vs. Zestril (lisinopril)
31%
-17% worse vs. Zestril (lisinopril)
Have you used Lanoxin (digoxin)?
Worth itNot sureNot worth it
Side effects
LisinoprilDigoxin
  • Headache 4%
  • Dizziness 4%
  • Cough 3%
  • Low blood pressure 4%
  • Chest pain 2%
  • Kidney damage 10%
  • Fainting 7%
  • High potassium 6%
More Lisinopril side effects »
  • Any side effect 20%
  • Dizziness 1%
  • Mental disturbances 4%
  • Nausea 1%
  • Diarrhea 3%
  • Death 1%
  • Side effects requiring hospitalization 1%
  • Abnormally fast heart beat 2%
  • Vomiting 2%
More Digoxin side effects »
How it works
LisinoprilDigoxin
Zestril (lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Digoxin helps your heart work more efficiently. It makes your heart pump slower and stronger, which helps it get more blood and oxygen out to your body and organs.
Type of medication
LisinoprilDigoxin
Prescription only
Prescription only
Available as
LisinoprilDigoxin
  • Pill
  • Liquid
  • Pill
  • Liquid
Used for
LisinoprilDigoxin
Risk factors for serious side effects
LisinoprilDigoxin
  • Women of childbearing age
  • African descent
  • Current kidney problems
  • Medicines that increase potassium
  • Use of salt substitutes
Detailed Zestril (lisinopril) risks & warnings »
  • History of heart problems
  • Drug interactions
  • Wolff-Parkinson-White syndrome
  • Low body weight, advanced age, impaired renal function, electrolyte imbalances
  • Overactive or underactive thyroid
Detailed Lanoxin (digoxin) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
LisinoprilDigoxin
No interactions related info.
  • Tell your doctor about other medicines you're taking to avoid drug interactions.
Kidneys and liver
LisinoprilDigoxin
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • You'll need to have blood tests done to check your kidney function.
No kidneys and liver related info.
Upsides and benefits
LisinoprilDigoxin
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Very cheap drug, and comes available as a liquid for children over 6 years of age.
  • Used for some abnormal heart rhythms, and for heart failure that can't be controlled by other medications.
  • Relieves shortness of breath, and makes it easier to be active without having symptoms.
  • In studies, Digoxin lowered the risk of having to be admitted to the hospital for worsening heart failure.
Downsides and risks
LisinoprilDigoxin
  • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Zestril (lisinopril) isn't safe to use if you're pregnant.
  • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
  • For heart failure, relieves symptoms, but does not lower the risk of death. That's why it's usually used together with other heart failure medicines that do lower the risk of death.
  • Requires blood tests, especially during the first few weeks of treatment.
Tips from our pharmacists for people taking the medication
LisinoprilDigoxin
  • Can cause dizziness the first few days you're taking it.
  • Check your blood pressure about 1 week after starting Zestril (lisinopril), and tell your doctor if it hasn't improved.
  • Let your doctor know about any dizziness, tiredness, cough, or throat irritation that doesn't go away.
  • You'll need to have blood tests done to check your kidney function.
  • Don't take Zestril (lisinopril) if you're pregnant.
  • Take it at the same time every day.
  • Drink plenty of water while taking this medicine.
  • Requires routine blood tests to make sure you have the right amount of Digoxin in your body.
  • Tell your doctor about other medicines you're taking to avoid drug interactions.
Learn more
More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zestril (lisinopril)?
Worth itNot sureNot worth it
More about DigoxinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lanoxin (digoxin)?
Worth itNot sureNot worth it