Compare Lisinopril vs. digoxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril (lisinopril)

Prescription only

Lanoxin (digoxin)

Prescription only
Lowers blood pressure.

Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.

3.8/ 5 average rating with 687 reviewsforLisinopril
Improves heart pumping.

Lanoxin (digoxin) is effective at treating heart failure symptoms, but it doesn't lower your risk of death compared to other heart failure medicines.

3.3/ 5 average rating with 70 reviewsfordigoxin
Upsides
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Very cheap drug, and comes available as a liquid for children over 6 years of age.
  • Lanoxin (digoxin) is used for abnormal heart rhythms, and for heart failure that can't be controlled by other medications.
  • Lanoxin (digoxin) does not need dose adjustments with people with liver problems.
  • Lanoxin (digoxin) is available in a generic form.
  • Lanoxin (digoxin) can be taken once daily.
Downsides
  • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Zestril (lisinopril) isn't safe to use if you're pregnant.
  • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
  • Lanoxin (digoxin) relieves heart failure symptoms, but doesn't lower your risk of death. It's usually used together with other medicines that help lower the risk of death in heart failure.
  • Use of Lanoxin (digoxin) requires blood tests, especially during the first few weeks of treatment to monitor drug level in the body.
  • If your blood levels of Lanoxin (digoxin) are too high, it can be life threatening.
  • Lanoxin (digoxin) is usually not an option for people with kidney problems.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
687 reviews so far
61%
saidit'sworth it
51%
saiditworked well
14%
saidit'sa big hassle

Have you used Zestril (lisinopril)?

Leave a review
70 reviews so far
64%
saidit'sworth it
43%
saiditworked well
31%
saidit'sa big hassle

Have you used Lanoxin (digoxin)?

Leave a review
Side effects
1possible side effects
  • Low blood pressure
    5%
See more detailed side effects
9possible side effects
  • Dizziness
    5%
  • Mental disturbances
    4%
  • Nausea
    3%
  • Diarrhea
    3%
  • Headache
    3%
  • Death
    3%
  • Increased heart rate
    2%
  • Vomiting
    2%
  • Rash
    2%
See more detailed side effects
Risks and risk factors
  • Harm to fetus
    • Women of childbearing age
  • Cough
  • Swelling of face and head
    • African descent
  • High potassium
    • Current kidney problems
    • Medicines that increase potassium
    • Use of salt substitutes
  • Worsening kidney problems
    • History of kidney problems
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
See more detailed risks and warnings
  • Irregular heartbeat
    • History of heart problems
    • Drug interactions
    • Wolff-Parkinson-White syndrome
  • Digoxin toxicity
    • Low body weight
    • Elderly (>65 years old)
    • Worsening kidney function
    • Electrolyte imbalances
  • Thyroid imbalance
    • Overactive or underactive thyroid
See more detailed risks and warnings