Compare Lisinopril vs. Digoxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Improves heart pumping. Digoxin is a good backup for treating heart failure symptoms, but it doesn't, by itself, lower your risk of death.
How it works
Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Digoxin helps your heart work more efficiently. It makes your heart pump slower and stronger, which helps it get more blood and oxygen out to your body and organs.
Type of medication
ACE inhibitor
Prescription only
Prescription only
Available as
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Zestril (Lisinopril)
of people say Zestril (Lisinopril) is worth it
say it works well
say it's a big hassle
Reviews for Lanoxin (Digoxin)
+3% vs. Zestril (Lisinopril)
8% vs. Zestril (Lisinopril)
18% vs. Zestril (Lisinopril)
Side effects
  • Dizziness 7%
  • Headache 4%
  • Cough 3%
  • Diarrhea 2%
  • Chest pain 2%
  • Fatigue 2%
  • Upper respiratory infection 1%
More Lisinopril side effects »
  • Dizziness 1%
  • Side effects requiring hospitalization 1%
  • Nausea 1%
  • Death 1%
More Digoxin side effects »
Risk factors for serious side effects
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Zestril (Lisinopril) risks & warnings »
    • History of heart problems
    • Drug interactions
    • Wolff-Parkinson-White syndrome
    • Low body weight, advanced age, impaired renal function, electrolyte imbalances
    • Overactive or underactive thyroid
    • Aspirin allergy
    • Electrocardioversion
    Detailed Lanoxin (Digoxin) risks & warnings »
    Pregnancy category
    No specific alcohol-related info.No specific alcohol-related info.
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires routine blood tests to check kidney function.
    No specific kidneys and liver-related info.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.No specific sleep-related info.
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    • A first-choice blood pressure treatment for many people.
    • Lowers the risk of heart attack and stroke.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    • Used for some abnormal heart rhythms, and for heart failure that can't be controlled by other medications.
    • Relieves shortness of breath, and makes it easier to be active without having symptoms.
    • In studies, Digoxin lowered the risk of having to be admitted to the hospital for worsening heart failure.
    Downsides and risks
    • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    • For heart failure, relieves symptoms, but does not lower the risk of death. That's why it's usually used together with other heart failure medicines that do lower the risk of death.
    • Requires blood tests, especially during the first few weeks of treatment.
    Tips from our pharmacists for people taking the medication
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    • Take it at the same time every day.
    • Drink plenty of water while taking this medicine.
    • Requires routine blood tests to make sure you have the right amount of Digoxin in your body.
    • Tell your doctor about other medicines you're taking to avoid drug interactions.
    Learn more
    More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
    More about DigoxinSide effectsReviews & ratingsAlternativesFDA package insert