Compare Lisinopril vs. Lopressor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(Lisinopril)

Lopressor
(Metoprolol Tartrate)

Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure and controls heart rate. Lopressor (Metoprolol Tartrate) is good for controlling chest pain and treating heart failure and heart attack. You have to take it with food, and you can't miss doses.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.17Lisinopril
Reviews for Zestril (Lisinopril)
61%
of people (All ages) say Zestril (Lisinopril) is worth it
51%
say it works well
14%
say it's a big hassle
687 reviews
Have you used Zestril (Lisinopril)?
Worth itNot sureNot worth it
Reviews for Lopressor (Metoprolol Tartrate)
62%
+1% better vs. Zestril (Lisinopril)
47%
-4% worse vs. Zestril (Lisinopril)
15%
-1% worse vs. Zestril (Lisinopril)
464 reviews
Have you used Lopressor (Metoprolol Tartrate)?
Worth itNot sureNot worth it
Side effects
LisinoprilLopressor
  • Headache 4%
  • Dizziness 3%
  • Cough 3%
  • Diarrhea 1%
  • Fatigue 2%
  • Infection 2%
  • Low blood pressure 4%
  • Chest pain 2%
More Lisinopril side effects »
  • Tiredness 10%
  • Dizziness 10%
  • Low mood disorder 5%
  • Diarrhea 5%
  • Itching 5%
  • Shortness of breath 3%
  • Abnormally slow heartbeat 3%
  • Low blood pressure 4%
More Lopressor side effects »
How it works
LisinoprilLopressor
Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Lopressor (Metoprolol Tartrate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
LisinoprilLopressor
Prescription only
Prescription only
Available as
LisinoprilLopressor
  • Pill
  • Pill
Used for
LisinoprilLopressor
Risk factors for serious side effects
LisinoprilLopressor
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Zestril (Lisinopril) risks & warnings »
    • Diabetes
      • Coronary artery disease
      • Heart failure
      • Major surgery requiring anesthesia
      • History of asthma
      Detailed Lopressor (Metoprolol Tartrate) risks & warnings »
      Pregnancy

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      LisinoprilLopressor
      No food related info.
      • Take it with food.
      Kidneys and liver
      LisinoprilLopressor
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Requires routine blood tests to check kidney function.
      No kidneys and liver related info.
      Upsides and benefits
      LisinoprilLopressor
      • A first-choice blood pressure treatment for many people.
      • Lowers the risk of heart attack and stroke.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
      • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
      • A first-choice treatment for heart failure. May prevent long-term heart damage.
      • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
      Downsides and risks
      LisinoprilLopressor
      • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
      • Requires a yearly blood test to see how the medicine is affecting your body.
      • Not safe to use if you're pregnant.
      • Metoprolol tartrate is the immediate release version of Toprol XL. You have to take Metoprolol tartrate with food for it to work best. (On the other hand, you can take Toprol XL any time.)
      • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
      • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
      • Can hide symptoms of low blood sugar if you're diabetic.
      • You can't miss doses. Stopping Metoprolol tartrate suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      Tips from our pharmacists for people taking the medication
      LisinoprilLopressor
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
      • Requires routine blood tests to check kidney function.
      • Don't take it if you're pregnant.
      • Take it with food.
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Can cause fatigue and headache.
      • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
      • Don't stop taking this medicine suddenly.
      • This is the immediate release version. It also comes as an extended release form: Toprol XL (metoprolol succinate).
      Learn more
      More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Zestril (Lisinopril)?
      Worth itNot sureNot worth it
      More about LopressorSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Lopressor (Metoprolol Tartrate)?
      Worth itNot sureNot worth it