Compare Lisinopril vs. Losartan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(Lisinopril)

Cozaar
(Losartan)

Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Cozaar (Losartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.17Lisinopril
Reviews for Zestril (Lisinopril)
61%
of people (All ages) say Zestril (Lisinopril) is worth it
51%
say it works well
14%
say it's a big hassle
687 reviews
Have you used Zestril (Lisinopril)?
Worth itNot sureNot worth it
Reviews for Cozaar (Losartan)
57%
-4% worse vs. Zestril (Lisinopril)
48%
-3% worse vs. Zestril (Lisinopril)
16%
-2% worse vs. Zestril (Lisinopril)
535 reviews
Have you used Cozaar (Losartan)?
Worth itNot sureNot worth it
Side effects
LisinoprilLosartan
  • Headache 4%
  • Dizziness 3%
  • Cough 3%
  • Diarrhea 1%
  • Fatigue 2%
  • Infection 2%
  • Low blood pressure 4%
  • Chest pain 2%
More Lisinopril side effects »
  • Upper respiratory infection 1%
  • Dizziness 1%
  • Back pain 1%
  • Nasal congestion 1%
  • Urinary tract infection 6%
  • Diarrhea 5%
  • Muscle weakness/fatiguea/fatigue 4%
  • Low red blood cells 3%
  • Low blood sugar 4%
  • Back pain 2%
More Losartan side effects »
How it works
LisinoprilLosartan
Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Cozaar (Losartan) is an angiotensin receptor blocker (ARB). It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
Type of medication
LisinoprilLosartan
Prescription only
Prescription only
Available as
LisinoprilLosartan
  • Pill
  • Pill
Used for
LisinoprilLosartan
Risk factors for serious side effects
LisinoprilLosartan
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Zestril (Lisinopril) risks & warnings »
    • Women of childbearing age
    • Concurrent liver disease
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Cozaar (Losartan) risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Kidneys and liver
    LisinoprilLosartan
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires routine blood tests to check kidney function.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires routine blood tests to check kidney function.
    Upsides and benefits
    LisinoprilLosartan
    • A first-choice blood pressure treatment for many people.
    • Lowers the risk of heart attack and stroke.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    • A first-choice blood pressure treatment for many people.
    • Lowers the risk of heart attack and stroke.
    • Similar to ACE inhibitors (like Lisinopril), with fewer side effects like cough and swelling.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    Downsides and risks
    LisinoprilLosartan
    • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    Tips from our pharmacists for people taking the medication
    LisinoprilLosartan
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    Learn more
    More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zestril (Lisinopril)?
    Worth itNot sureNot worth it
    More about LosartanSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Cozaar (Losartan)?
    Worth itNot sureNot worth it