Compare Lisinopril vs. Nifedipine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(lisinopril)

Procardia
(nifedipine)

Lowers blood pressure. Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure and controls heart rate. Nifedipine works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding grapefruit. You can't miss doses, and you might get persistent swelling.
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Coupons for Lisinopril
Best available price for 30 (20mg) tablets of lisinopril
Coupons for Nifedipine
Best available price for 90 (10mg) capsules of nifedipine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.17Lisinopril
Reviews for Zestril (lisinopril)
61%
of people (All ages) say Zestril (lisinopril) is worth it
51%
say it works well
14%
say it's a big hassle
687 reviews
Have you used Zestril (lisinopril)?
Worth itNot sureNot worth it
Reviews for Procardia (nifedipine)
42%
-19% worse vs. Zestril (lisinopril)
31%
-20% worse vs. Zestril (lisinopril)
46%
-32% worse vs. Zestril (lisinopril)
Have you used Procardia (nifedipine)?
Worth itNot sureNot worth it
Side effects
LisinoprilNifedipine
  • Headache 4%
  • Dizziness 4%
  • Cough 3%
  • Low blood pressure 4%
  • Chest pain 2%
  • Kidney damage 10%
  • Fainting 7%
  • High potassium 6%
More Lisinopril side effects »
  • Dizziness, lightheadedness, giddiness 12%
  • Flushing 17%
  • Headache 3%
  • Weakness 2%
  • Nausea, heartburn 3%
  • Muscle cramps, tremor 5%
  • Leg or ankle swelling 6%
  • Nervousness, mood changes 3%
  • Heart pounding or racing sensation 2%
  • Dyspnea, cough, wheezing 3%
More Nifedipine side effects »
How it works
LisinoprilNifedipine
Zestril (lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Nifedipine is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.
Type of medication
LisinoprilNifedipine
Prescription only
Prescription only
Available as
LisinoprilNifedipine
  • Pill
  • Liquid
  • Pill
  • Extended release
Used for
LisinoprilNifedipine
Risk factors for serious side effects
LisinoprilNifedipine
  • Women of childbearing age
  • African descent
  • Current kidney problems
  • Medicines that increase potassium
  • Use of salt substitutes
Detailed Zestril (lisinopril) risks & warnings »
  • Taking anti-inflammatories, acid reducers in the stomach, anticholinergics, laxatives, levothyroxine
  • History of intestinal surgery
  • Taking beta-blockers
  • Severe coronary artery disease.
  • History of cirrhosis
Detailed Procardia (nifedipine) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
LisinoprilNifedipine
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • You'll need to have blood tests done to check your kidney function.
  • Reports of liver damage have occurred while on this medication, especially if you have had cirrhosis. Your doctor will monitor your liver on a regular basis. Tell your doctor if you or your caregivers/family notice your skin or the whites of your eyes are becoming yellower, pain in your abdomen, or sudden confusion.
Upsides and benefits
LisinoprilNifedipine
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Very cheap drug, and comes available as a liquid for children over 6 years of age.
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • You can take it alone or with other medicines to help lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Treats certain abnormal heart rhythms.
Downsides and risks
LisinoprilNifedipine
  • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Zestril (lisinopril) isn't safe to use if you're pregnant.
  • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Nifedipine than men.
  • You can't miss doses. Stopping Nifedipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Not a good medication for you if you love grapefruit. It can make Nifedipine have a stronger effect on your blood pressure.
Tips from our pharmacists for people taking the medication
LisinoprilNifedipine
  • Can cause dizziness the first few days you're taking it.
  • Check your blood pressure about 1 week after starting Zestril (lisinopril), and tell your doctor if it hasn't improved.
  • Let your doctor know about any dizziness, tiredness, cough, or throat irritation that doesn't go away.
  • You'll need to have blood tests done to check your kidney function.
  • Don't take Zestril (lisinopril) if you're pregnant.
  • Can cause dizziness or headaches in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can cause face flushing and ankle or foot swelling.
  • Avoid grapefruit while taking this medicine.
  • Your doctor might do routine blood tests to check your liver function.
Learn more
More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zestril (lisinopril)?
Worth itNot sureNot worth it
More about NifedipineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Procardia (nifedipine)?
Worth itNot sureNot worth it