Compare Lisinopril vs. Norvasc

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(Lisinopril)

Norvasc
(Amlodipine)

Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Norvasc (Amlodipine) works well to lower blood pressure and prevent chest pain. You can't miss doses, and you might get persistent swelling.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.164201183431953Lisinopril
Reviews for Zestril (Lisinopril)
61%
of people (All ages) say Zestril (Lisinopril) is worth it
51%
say it works well
13%
say it's a big hassle
676 reviews
Have you used Zestril (Lisinopril)?
Worth itNot sureNot worth it
Reviews for Norvasc (Amlodipine)
59%
2% vs. Zestril (Lisinopril)
50%
1% vs. Zestril (Lisinopril)
14%
1% vs. Zestril (Lisinopril)
435 reviews
Have you used Norvasc (Amlodipine)?
Worth itNot sureNot worth it
Side effects
LisinoprilNorvasc
  • Dizziness 7%
  • Headache 4%
  • Cough 3%
  • Diarrhea 2%
  • Chest pain 2%
  • Fatigue 2%
  • Upper respiratory infection 1%
More Lisinopril side effects »
  • Swelling due to excess fluid 10%
  • Fatigue 2%
  • Nausea 1%
  • Dizziness 1%
More Norvasc side effects »
How it works
LisinoprilNorvasc
Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Norvasc (Amlodipine) is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.
Type of medication
LisinoprilNorvasc
Antihypertensive
ACE inhibitor
Prescription only
Antihypertensive
Calcium channel blocker
Prescription only
Available as
LisinoprilNorvasc
  • Pill
  • Pill
Used for (click to learn more)
LisinoprilNorvasc
Risk factors for serious side effects
LisinoprilNorvasc
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Zestril (Lisinopril) risks & warnings »
    • Age 65 years or older
    • History of heart problems
    • Liver disease
    • History of blood vessel disease
    • History of heart failure
    • History of kidney disease
    • Obesity
    Detailed Norvasc (Amlodipine) risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    LisinoprilNorvasc
    No interactions related info.
    • Interacts with the cholesterol medicine Simvastatin.
    Kidneys and liver
    LisinoprilNorvasc
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires routine blood tests to check kidney function.
    • Might not be a good choice if you have liver disease.
    • Your body uses your liver to break down Norvasc (Amlodipine) and remove it from your blood. If you have liver disease you may not be able to remove Norvasc (Amlodipine) as quickly from your blood as someone with a healthy liver. You should increase the dose of Norvasc (Amlodipine) slowly and watch closely for how it is working in your body. Increasing the dose slowly will lower your chances of having side effects.
    Pain
    LisinoprilNorvasc
    No pain related info.
    • Worsening heart pain or increased risk of heart attack is possible when you first start taking Norvasc (Amlodipine). This can also happen after you increase the dose of Norvasc (Amlodipine). Notify your doctor immediately if you experience any heart pain, radiating jaw pain, crushing chest pain, or persistent racing heartbeat.
    Upsides and benefits
    LisinoprilNorvasc
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    • A first-choice blood pressure treatment for many people.
    • Lowers the risk of heart attack and stroke.
    • Calcium channel blockers work especially well for African Americans to lower blood pressure.
    • Prevents heart-related chest pain (angina) if you take it regularly.
    • Each dose lasts longer than other calcium channel blockers, which keeps blood pressure consistent without big ups and downs.
    • Particularly good at lowering systolic blood pressure (the top number), so it's a good option for older people who can commonly get high blood pressure only in the top number.
    • A first-choice blood pressure treatment for many people.
    • Lowers the risk of heart attack and stroke.
    Downsides and risks
    LisinoprilNorvasc
    • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
    • Women are more likely to have side effects (especially swelling) from Amlodipine than men.
    • Some people might experience flushing with this medication.
    • You can't miss doses. Stopping Amlodipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
    • If you have severe heart disease, using Amlodipine might increase your risk of chest pain or heart attack during the time right after starting the medication or raising the dosage.
    • Might not be a good choice if you have liver disease.
    Tips from our pharmacists for people taking the medication
    LisinoprilNorvasc
    • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Interacts with the cholesterol medicine Simvastatin.
    • Can cause ankle or foot swelling.
    • Can cause gum overgrowth. Ask your dentist to check for this side effect.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    Learn more
    More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zestril (Lisinopril)?
    Worth itNot sureNot worth it
    More about NorvascSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Norvasc (Amlodipine)?
    Worth itNot sureNot worth it