Compare Lisinopril vs. Prazosin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril (lisinopril)

Prescription only

Minipress (Prazosin)

Prescription only
Lowers blood pressure.

Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.

3.8/ 5 average rating with 687 reviewsforLisinopril
Lowers blood pressure and makes it easier to urinate.

Prazosin is used mostly to make urination easier for men with an enlarged prostate, but it can cause dizziness.

3.0/ 5 average rating with 48 reviewsforPrazosin
Upsides
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Very cheap drug, and comes available as a liquid for children over 6 years of age.
  • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
  • Makes urination easier in men with an enlarged prostate.
  • Helps people with PTSD get better sleep with fewer, less-intense nightmares.
Downsides
  • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Zestril (lisinopril) isn't safe to use if you're pregnant.
  • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
  • Not the best medicine to lower blood pressure by itself.
  • Likely to cause orthostatic hypotension. This means dizziness when you change positions (like standing up) because your blood pressure doesn't adjust quickly enough.
  • Not preferred for people 65 years or older.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
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Reviews
687 reviews so far
61%
saidit'sworth it
51%
saiditworked well
14%
saidit'sa big hassle

Have you used Zestril (lisinopril)?

Leave a review
48 reviews so far
46%
saidit'sworth it
29%
saiditworked well
15%
saidit'sa big hassle

Have you used Minipress (Prazosin)?

Leave a review
Side effects
1possible side effects
  • Low blood pressure
    5%
See more detailed side effects
7possible side effects
  • Dizziness
    10%
  • Headache
    8%
  • Drowsiness
    8%
  • Lack of energy
    7%
  • Weakness
    7%
  • Palpitations
    5%
  • Nausea
    5%
See more detailed side effects
Risks and risk factors
  • Harm to fetus
    • Women of childbearing age
  • Cough
  • Swelling of face and head
    • African descent
  • High potassium
    • Current kidney problems
    • Medicines that increase potassium
    • Use of salt substitutes
  • Worsening kidney problems
    • History of kidney problems
  • Low blood pressure
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
See more detailed risks and warnings
  • Low blood pressure (orthostatic hypotension)
    • Age 65 years or older
See more detailed risks and warnings