Compare Lisinopril vs. Prazosin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(Lisinopril)

Minipress
(Prazosin)

Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure and makes it easier to urinate. Prazosin is used mostly to make urination easier for men with an enlarged prostate, but it can cause dizziness.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.164201183431953Lisinopril
Reviews for Zestril (Lisinopril)
61%
of people say Zestril (Lisinopril) is worth it
51%
say it works well
13%
say it's a big hassle
Reviews for Minipress (Prazosin)
43%
18% vs. Zestril (Lisinopril)
28%
23% vs. Zestril (Lisinopril)
15%
2% vs. Zestril (Lisinopril)
Side effects
LisinoprilPrazosin
  • Dizziness 7%
  • Headache 4%
  • Cough 3%
  • Diarrhea 2%
  • Chest pain 2%
  • Fatigue 2%
  • Upper respiratory infection 1%
More Lisinopril side effects »

The Prazosin FDA package insert doesn’t have numbers about how common side effects are.

More about Prazosin side effects »
How it works
LisinoprilPrazosin
Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Prazosin is a selective alpha blocker. It lowers blood pressure by relaxing blood vessels. It also relaxes the urethra and prostate, which makes it easier to urinate.
Type of medication
LisinoprilPrazosin
Antihypertensive
ACE inhibitor
Prescription only
Antihypertensive
Alpha blocker
Prescription only
Available as
LisinoprilPrazosin
  • Pill
  • Pill
Used for (click to learn more)
LisinoprilPrazosin
Risk factors for serious side effects
LisinoprilPrazosin
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Zestril (Lisinopril) risks & warnings »
    • Age 65 years or older
    Detailed Minipress (Prazosin) risks & warnings »
    Pregnancy category
    LisinoprilPrazosin
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.
    • Take with food or at bedtime to avoid side effects.
    Kidneys and liver
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires routine blood tests to check kidney function.
    No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.
    • Helps people with PTSD get better sleep with fewer, less-intense nightmares.
    • Can cause drowsiness, headache, dizziness, and nausea.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    LisinoprilPrazosin
    • A first-choice blood pressure treatment for many people.
    • Lowers the risk of heart attack and stroke.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
    • Makes urination easier in men with an enlarged prostate.
    • Helps people with PTSD get better sleep with fewer, less-intense nightmares.
    Downsides and risks
    LisinoprilPrazosin
    • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    • Not the best medicine to lower blood pressure by itself.
    • Likely to cause orthostatic hypotension. This means dizziness when you change positions (like standing up) because your blood pressure doesn't adjust quickly enough.
    • Not preferred for people 65 years or older.
    Tips from our pharmacists for people taking the medication
    LisinoprilPrazosin
    • Can cause dizziness in the first few days.
    • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Can cause drowsiness, headache, dizziness, and nausea.
    • Take with food or at bedtime to avoid side effects.
    • If side effects don't go away, talk to your doctor about alternatives.
    • Recheck your blood pressure 1 week after starting this medicine.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    Learn more
    More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
    More about PrazosinSide effectsReviews & ratingsAlternativesFDA package insert