Compare Lisinopril vs. Toprol XL

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(lisinopril)

Toprol XL
(metoprolol succinate)

Lowers blood pressure. Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure and controls heart rate. Toprol XL (metoprolol succinate) is good for controlling chest pain, treating heart failure, and heart attack. It has the added benefit of being taken once a day.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for
Prices and coupon for 30 (20mg) tablets of lisinopril
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.17Lisinopril
Reviews for Zestril (lisinopril)
61%
of people (All ages) say Zestril (lisinopril) is worth it
51%
say it works well
14%
say it's a big hassle
687 reviews
Have you used Zestril (lisinopril)?
Worth itNot sureNot worth it
Reviews for Toprol XL (metoprolol succinate)
60%
-1% worse vs. Zestril (lisinopril)
54%
+3% better vs. Zestril (lisinopril)
13%
+1% better vs. Zestril (lisinopril)
164 reviews
Have you used Toprol XL (metoprolol succinate)?
Worth itNot sureNot worth it
Side effects
LisinoprilToprol XL
  • Headache 4%
  • Dizziness 4%
  • Cough 3%
  • Low blood pressure 4%
  • Chest pain 2%
  • Kidney damage 10%
  • Fainting 7%
  • High potassium 6%
More Lisinopril side effects »
  • Tiredness 10%
  • Dizziness 10%
  • Low mood disorder 5%
  • Skin rash and itching 5%
  • Diarrhea 5%
  • Shortness of breath 3%
  • Slower heartbeat 3%
  • Dizziness/balance problems 1%
More Toprol XL side effects »
How it works
LisinoprilToprol XL
Zestril (lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Toprol XL (metoprolol succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
LisinoprilToprol XL
Prescription only
Prescription only
Available as
LisinoprilToprol XL
  • Pill
  • Liquid
  • Extended release
Used for
LisinoprilToprol XL
Risk factors for serious side effects
LisinoprilToprol XL
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicines that increase potassium
    • Use of salt substitutes
    • History of kidney problems
    • Taking with alcohol
    • Taking other medicines that lower your blood pressure
    Detailed Zestril (lisinopril) risks & warnings »
    • Sudden discontinuation of medicine
    • Coronary artery disease
    • Diabetes
    • Hyperthyroidsim
    • Heart failure
    • Major surgery requiring anesthesia
    • History of asthma
    • History of COPD
    Detailed Toprol XL (metoprolol succinate) risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Kidneys and liver
    LisinoprilToprol XL
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • You'll need to have blood tests done to check your kidney function.
    No kidneys and liver related info.
    Upsides and benefits
    LisinoprilToprol XL
    • A first-choice blood pressure treatment for many people.
    • Lowers the risk of heart attack and stroke.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    • Very cheap drug, and comes available as a liquid for children over 6 years of age.
    • A first-choice treatment to prevent chest pain (angina). It makes attacks less frequent and helps you be more active without having chest pain.
    • Toprol XL (metoprolol succinate) is a first-choice treatment for heart failure since it may prevent long-term heart damage.
    • It's also a first-choice for heart attack treatment since it lowers the risk of death during and after a heart attack.
    • Toprol XL (metoprolol succinate) is the extended release version of metoprolol tartrate and only needs to be taken once a day.
    • It's available as a generic and is relatively cheap.
    Downsides and risks
    LisinoprilToprol XL
    • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Zestril (lisinopril) isn't safe to use if you're pregnant.
    • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
    • Taking a beta blocker can make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some this may not go away.
    • It's not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
    • Toprol XL (metoprolol succinate) can hide symptoms of low blood sugar if you have diabetes.
    • You can't miss doses. Stopping Toprol XL (metoprolol succinate) suddenly can cause your blood pressure to go up quickly, which increases your risk of heart attack and stroke.
    Tips from our pharmacists for people taking the medication
    LisinoprilToprol XL
    • Can cause dizziness the first few days you're taking it.
    • Check your blood pressure about 1 week after starting Zestril (lisinopril), and tell your doctor if it hasn't improved.
    • Let your doctor know about any dizziness, tiredness, cough, or throat irritation that doesn't go away.
    • You'll need to have blood tests done to check your kidney function.
    • Don't take Zestril (lisinopril) if you're pregnant.
    • Toprol XL (metoprolol succinate) cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine and let your doctor know if it hasn't improved.
    • It can make you feel tired or give you headaches.
    • Can hide symptoms of low blood sugar, so be careful taking this if you have diabetes.
    • Don't stop taking this medicine suddenly.
    • This is the extended-release version, but it also comes in an immediate-release form, metoprolol tartrate.
    Learn more
    More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zestril (lisinopril)?
    Worth itNot sureNot worth it
    More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Toprol XL (metoprolol succinate)?
    Worth itNot sureNot worth it