Compare Lisinopril vs. Zestoretic

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(Lisinopril)

Zestoretic
(Lisinopril / Hydrochlorothiazide)

Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.164201183431953Lisinopril
Reviews for Zestril (Lisinopril)
61%
of people (All ages) say Zestril (Lisinopril) is worth it
51%
say it works well
13%
say it's a big hassle
676 reviews
Have you used Zestril (Lisinopril)?
Worth itNot sureNot worth it
Reviews for Zestoretic (Lisinopril / Hydrochlorothiazide)
51%
10% vs. Zestril (Lisinopril)
40%
11% vs. Zestril (Lisinopril)
17%
4% vs. Zestril (Lisinopril)
294 reviews
Have you used Zestoretic (Lisinopril / Hydrochlorothiazide)?
Worth itNot sureNot worth it
Side effects
LisinoprilZestoretic
  • Dizziness 7%
  • Headache 4%
  • Cough 3%
  • Diarrhea 2%
  • Chest pain 2%
  • Fatigue 2%
  • Upper respiratory infection 1%
More Lisinopril side effects »
  • Dizziness 6%
  • Headache 3%
  • Cough 3%
  • Fatigue 3%
  • Orthostatic effects 2%
  • Muscle weakness 1%
  • Diarrhea 1%
More Zestoretic side effects »
How it works
LisinoprilZestoretic
Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Lisinopril/hydrochlorothiazide is a combination medicine. Lisinopril (an ACE inhibitor) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.
Type of medication
LisinoprilZestoretic
Antihypertensive
ACE inhibitor
Prescription only
Antihypertensive
ACE inhibitor
Diuretic
Prescription only
Available as
LisinoprilZestoretic
  • Pill
  • Pill
Used for (click to learn more)
LisinoprilZestoretic
Risk factors for serious side effects
LisinoprilZestoretic
  • Women of childbearing age
    • African descent
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    Detailed Zestril (Lisinopril) risks & warnings »
    • Women of childbearing age
    • African descent
    • People requiring high flux dialysis
    • History of kidney disease
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
      Detailed Zestoretic (Lisinopril / Hydrochlorothiazide) risks & warnings »
      Pregnancy

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Kidneys and liver
      LisinoprilZestoretic
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Requires routine blood tests to check kidney function.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Requires routine blood tests to check kidney function.
      • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause severe allergic reactions, including death, to patients who required certain types of kidney dialysis. Talk to your prescriber if you are undergoing dialysis to discuss possible alternative medications.
      • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
      Upsides and benefits
      LisinoprilZestoretic
      • A first-choice blood pressure treatment for many people.
      • Lowers the risk of heart attack and stroke.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
      • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
      • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
      Downsides and risks
      LisinoprilZestoretic
      • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
      • Requires a yearly blood test to see how the medicine is affecting your body.
      • Not safe to use if you're pregnant.
      • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
      • Makes you urinate more often.
      • Doesn't work as well in people with severe kidney problems.
      • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
      • Requires a yearly blood test to see how the medicine is affecting your body.
      • Not safe to use if you're pregnant.
      Tips from our pharmacists for people taking the medication
      LisinoprilZestoretic
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
      • Requires routine blood tests to check kidney function.
      • Don't take it if you're pregnant.
      • Makes you urinate more often, so avoid taking it at bedtime.
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
      • Requires routine blood tests to check kidney function.
      • Don't take it if you're pregnant.
      Learn more
      More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Zestril (Lisinopril)?
      Worth itNot sureNot worth it
      More about ZestoreticSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Zestoretic (Lisinopril / Hydrochlorothiazide)?
      Worth itNot sureNot worth it