Compare Lisinopril vs. Zestoretic

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zestril
(lisinopril)

Zestoretic
(Lisinopril / Hydrochlorothiazide)

Lowers blood pressure. Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.Lowers blood pressure. Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.17Lisinopril
Reviews for Lisinopril
61%
of people (All ages) say Lisinopril is worth it
51%
say it works well
14%
say it's a big hassle
687 reviews
Have you used Zestril (lisinopril)?
Worth itNot sureNot worth it
Reviews for Zestoretic
51%
+10% better vs. Lisinopril
40%
+11% better vs. Lisinopril
17%
+3% better vs. Lisinopril
294 reviews
Have you used Zestoretic (Lisinopril / Hydrochlorothiazide)?
Worth itNot sureNot worth it
Side effects
LisinoprilZestoretic
  • Cough 3%
  • Headache 4%
  • Dizziness 4%
  • Chest pain 2%
  • Low blood pressure 4%
  • High potassium 6%
  • Fainting 7%
  • Kidney damage 10%
More Lisinopril side effects »
  • Upper Respiratory Infection 2%
  • Muscle Cramps 2%
  • Asthenia 1%
  • Paresthesia 2%
  • Orthostatic Effects 2%
  • Diarrhea 1%
  • Cough 3%
  • Fatigue 3%
  • Headache 3%
More Zestoretic side effects »
How it works
LisinoprilZestoretic
Zestril (lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.Lisinopril/hydrochlorothiazide is a combination medicine. Lisinopril (an ACE inhibitor) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.
Type of medication
LisinoprilZestoretic
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
LisinoprilZestoretic
  • Pill
  • Liquid
  • Pill
Used for
LisinoprilZestoretic
Risk factors for serious side effects
LisinoprilZestoretic
  • Women of childbearing age
  • African descent
  • Current kidney problems
  • Medicines that increase potassium
  • Use of salt substitutes
Detailed Zestril (lisinopril) risks & warnings »
  • Women of childbearing age
  • African descent
  • People requiring high flux dialysis
  • History of kidney disease
  • Current kidney problems
Detailed Zestoretic (Lisinopril / Hydrochlorothiazide) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
LisinoprilZestoretic
  • You'll need to have blood tests done to check your kidney function.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause severe allergic reactions, including death, to patients who required certain types of kidney dialysis. Talk to your prescriber if you are undergoing dialysis to discuss possible alternative medications.
  • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
  • Requires routine blood tests to check kidney function.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
Upsides and benefits
LisinoprilZestoretic
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Very cheap drug, and comes available as a liquid for children over 6 years of age.
  • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
  • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
Downsides and risks
LisinoprilZestoretic
  • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Zestril (lisinopril) isn't safe to use if you're pregnant.
  • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
  • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Makes you urinate more often.
  • Doesn't work as well in people with severe kidney problems.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
Tips from our pharmacists for people taking the medication
LisinoprilZestoretic
  • Can cause dizziness the first few days you're taking it.
  • Check your blood pressure about 1 week after starting Zestril (lisinopril), and tell your doctor if it hasn't improved.
  • Let your doctor know about any dizziness, tiredness, cough, or throat irritation that doesn't go away.
  • You'll need to have blood tests done to check your kidney function.
  • Don't take Zestril (lisinopril) if you're pregnant.
  • Makes you urinate more often, so avoid taking it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
Learn more
More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zestril (lisinopril)?
Worth itNot sureNot worth it
More about ZestoreticSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zestoretic (Lisinopril / Hydrochlorothiazide)?
Worth itNot sureNot worth it