Compare Lithium vs. Seroquel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lithobid (Lithium)

Prescription only

Seroquel (quetiapine)

Prescription only
Stabilizes mood.

Lithobid (Lithium) is the most effective long-term treatment for bipolar disorder, but it comes with a lot of side effects, so it can be difficult to take.

Helps control your thoughts and mood.

Seroquel (quetiapine) is a effective at treating schizophrenia, mania, and depression but it can cause weight gain and high blood glucose levels.

5.0/ 7 average rating with 250 reviewsforSeroquel
  • A first-line, long-term treatment for bipolar disorder. Effective at stabilizing mood and preventing relapse.
  • For manic episodes (acute mania), more effective when taken together with an antipsychotic medicine.
  • The only drug proven (so far) to lower the risk of suicide, possibly because it lowers aggressiveness and impulsivity.
  • Seroquel (quetiapine) is effective at relieving psychotic symptoms and manic episodes.
  • Seroquel (quetiapine) has fewer side effects than most antipsychotic medications.
  • Seroquel (quetiapine) is less likely to cause heart problems compared to some other antipsychotics.
  • Seroquel (quetiapine) is also the least likely to cause Extrapyramidal Symptoms (EPS) – a movement disorder that causes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Has many short- and long-term side effects.
  • The dose for it to work well is very close to the amount that causes overdose, so you have to be careful, watch out for symptoms, and get help immediately if you accidentally take too much.
  • Probably not safe if you have kidney problems.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
  • Seroquel (quetiapine) has a moderate to high risk of weight gain, elevated cholesterol and/or blood sugar compared to other antipsychotics.
  • You might need routine blood tests to check how Seroquel (quetiapine) is affecting your body.
Used for
Dosage forms
  • Pill
  • Extended release
  • Oral solution
  • Pill
  • Extended release
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Side effects
The Lithobid (Lithium) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Drowsiness
  • Dry mouth
  • Headache
  • Weakness
  • Constipation
  • Dizziness
  • Tremor
  • Stomach pain
  • Low blood pressure
  • Agitation
See more detailed side effects
Risks and warnings
  • Overdose

    Low sodium

    ...and 2 more risk factors

  • Driving impairment


    ...and 1 more risk factors

  • Reduced kidney function

    Long-term use

See more detailed risks and warnings
  • Higher risk of death

    Elderly patients with dementia-related psychosis

  • Suicidal thoughts or behavior

    Children, adolescents, and young adults (<24 years old)

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Metabolic changes (increased blood sugar, high cholesterol and weight gain)

    People with diabetes

    ...and 1 more risk factors

See more detailed risks and warnings