Lodine vs. Acetaminophen with codeine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Tylenol #3
(Acetaminophen / Codeine)

Coming soon.Treats mild to moderate pain. Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
How it works
Coming soon.Tylenol #3 (Acetaminophen / Codeine) is a combination pain medicine. Codeine is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
Coming soon.
Pain reliever
Acetaminophen (APAP)
Prescription only
Available as
  • Pill
  • Extended release
  • Pill
  • Liquid
Used for (click to learn more)
  • Juvenile rheumatoid arthritis Osteoarthritis Pain Rheumatoid arthritis
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Tylenol #3 (Acetaminophen / Codeine)
+53% vs. Lodine (Etodolac)
+24% vs. Lodine (Etodolac)
+8% vs. Lodine (Etodolac)
Side effects

We haven’t found good data for Lodine side effects.

FDA side effect reports for Lodine »

The Acetaminophen with codeine FDA package insert doesn’t have numbers about how common side effects are.

More about Acetaminophen with codeine side effects »
Risk factors for serious side effects
Coming soon.Coming soon.
Pregnancy category
No specific alcohol-related info.
  • Avoid alcohol.
No specific food-related info.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
No specific sex-related info.No specific sex-related info.
No specific sleep-related info.No specific sleep-related info.
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Coming soon.
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relieve for mild to moderate pain to improve quality of life.
  • Good for as-needed pain and control.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides and risks
Coming soon.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Tips from our pharmacists for people taking the medication
Coming soon.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Starts working in 30 minutes.
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Can make you dizzy or drowsy.
  • Avoid activities need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
  • Don't take more than instructed to prevent liver damage.
  • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
  • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
Learn more
More about LodineSide effectsReviews & ratingsFDA package insert
More about Acetaminophen with codeineSide effectsReviews & ratingsAlternativesFDA package insert