Compare Lodine vs. Acetaminophen With Codeine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Lodine
(Etodolac)

Tylenol #3
(Acetaminophen / Codeine)

Coming soon.Treats mild to moderate pain. Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
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Reviews & ratings
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Have you used Lodine (Etodolac)?
Worth itNot sureNot worth it
Reviews for Tylenol #3 (Acetaminophen / Codeine)
69%
+39% vs. Lodine (Etodolac)
41%
+21% vs. Lodine (Etodolac)
9%
+1% vs. Lodine (Etodolac)
581 reviews
Have you used Tylenol #3 (Acetaminophen / Codeine)?
Worth itNot sureNot worth it
Side effects
LodineAcetaminophen With Codeine

We haven’t found good data for Lodine side effects.

FDA side effect reports for Lodine »

The Acetaminophen With Codeine FDA package insert doesn’t have numbers about how common side effects are.

More about Acetaminophen With Codeine side effects »
How it works
LodineAcetaminophen With Codeine
Coming soon.Tylenol #3 (Acetaminophen / Codeine) is a combination pain medicine. Codeine is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
LodineAcetaminophen With Codeine
Coming soon.
Pain reliever
Acetaminophen (APAP)
Opioid
Prescription only
Available as
LodineAcetaminophen With Codeine
  • Pill
  • Extended release
  • Pill
  • Liquid
Used for (click to learn more)
LodineAcetaminophen With Codeine
  • Juvenile rheumatoid arthritis Osteoarthritis Pain Rheumatoid arthritis
Risk factors for serious side effects
LodineAcetaminophen With Codeine
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
LodineAcetaminophen With Codeine
No alcohol related info.
  • Avoid alcohol.
Food
LodineAcetaminophen With Codeine
No food related info.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
LodineAcetaminophen With Codeine
No kidneys and liver related info.
  • Don't take more than instructed to prevent liver damage.
Pain
LodineAcetaminophen With Codeine
No pain related info.
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Good for as-needed pain and control.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
Sleep
LodineAcetaminophen With Codeine
No sleep related info.
  • Can help you fall asleep easier.
  • Dizziness and drowsiness is common, but your body may adjust.
Upsides and benefits
LodineAcetaminophen With Codeine
Coming soon
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relieve for mild to moderate pain to improve quality of life.
  • Good for as-needed pain and control.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides and risks
LodineAcetaminophen With Codeine
Coming soon
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Tips from our pharmacists for people taking the medication
LodineAcetaminophen With Codeine
Coming soon
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Starts working in 30 minutes.
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Can make you dizzy or drowsy.
  • Avoid activities need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
  • Don't take more than instructed to prevent liver damage.
  • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
  • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
Learn more
More about LodineSide effectsReviews & ratingsFDA package insert
Have you used Lodine (Etodolac)?
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More about Acetaminophen With CodeineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol #3 (Acetaminophen / Codeine)?
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