Compare Lodine vs. Naproxen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lodine
(Etodolac)

Aleve
(Naproxen)

Coming soon.Relieves pain, fever, and inflammation. Aleve (Naproxen) works well for mild to moderate pain and inflammation, and it lasts longer than other NSAIDs.
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Reviews & ratings
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Have you used Lodine (Etodolac)?
Worth itNot sureNot worth it
Reviews for Aleve (Naproxen)
78%
+48% better vs. Lodine (Etodolac)
48%
+28% better vs. Lodine (Etodolac)
5%
+5% better vs. Lodine (Etodolac)
978 reviews
Have you used Aleve (Naproxen)?
Worth itNot sureNot worth it
Side effects
LodineNaproxen

We haven’t found good data for Lodine side effects.

FDA side effect reports for Lodine »

The Naproxen FDA package insert doesn’t have numbers about how common side effects are.

More about Naproxen side effects »
How it works
LodineNaproxen
Coming soon.Aleve (Naproxen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.
Type of medication
LodineNaproxen
Prescription or OTC
Available as
LodineNaproxen
  • Pill
  • Extended release
  • Pill
  • Delayed release tablet
  • Liquid
Used for
LodineNaproxen
  • Juvenile Rheumatoid Arthritis Osteoarthritis Pain Rheumatoid Arthritis
Risk factors for serious side effects
LodineNaproxen
Coming soon.
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Hemophilia
  • von Willebrand's disease
  • Low blood platelet count
  • Taking anticoagulant medications
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • Women of childbearing age
Detailed Aleve (Naproxen) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
LodineNaproxen
No food related info.
  • It needs to be taken with food to avoid getting an upset stomach.
  • Take it with a meal or a snack to prevent an upset stomach.
Kidneys and liver
LodineNaproxen
No kidneys and liver related info.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Aleve (Naproxen) is an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Aleve (Naproxen) for any amount of time.
Pain
LodineNaproxen
No pain related info.
  • Works well to relieve pain, swelling, and fevers.
  • Starts relieving pain in 30 to 60 minutes.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
Upsides and benefits
LodineNaproxen
Coming soon
  • Works well to relieve pain, swelling, and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Lasts longer than Ibuprofen, so you can take it less often.
  • Aleve (Naproxen) works as well as Aspirin and Indomethacin to treat arthritis pain, and causes fewer stomach problems.
  • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
Downsides and risks
LodineNaproxen
Coming soon
  • It needs to be taken with food to avoid getting an upset stomach.
  • Can't be taken by pregnant women.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
Tips from our pharmacists for people taking the medication
LodineNaproxen
Coming soon
  • Starts relieving pain in 30 to 60 minutes.
  • Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
Learn more
More about LodineSide effectsReviews & ratingsFDA package insert
Have you used Lodine (Etodolac)?
Worth itNot sureNot worth it
More about NaproxenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aleve (Naproxen)?
Worth itNot sureNot worth it