Compare Lodine vs. Norco

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lodine
(etodolac)

Norco
(hydrocodone / acetaminophen)

Coming soon.Treats moderate to severe pain. Norco (Hydrocodone / Acetaminophen) is a good option to treat pain as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
Reviews & ratings
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Have you used Lodine (etodolac)?
Worth itNot sureNot worth it
Reviews for Norco
67%
-37% worse vs. Lodine
44%
-24% worse vs. Lodine
13%
+3% better vs. Lodine
1194 reviews
Have you used Norco (hydrocodone / acetaminophen)?
Worth itNot sureNot worth it
Side effects
LodineNorco

We haven’t found good data for Lodine side effects.

FDA side effect reports for Lodine »

The Norco FDA package insert doesn’t have numbers about how common side effects are.

More about Norco side effects »
How it works
LodineNorco
Coming soon.Norco (Hydrocodone / Acetaminophen) is a combination pain medicine. Hydrocodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
LodineNorco
Prescription only
Available as
LodineNorco
  • Pill
  • Extended release
  • Pill
  • Oral solution
Used for
LodineNorco
  • Juvenile Rheumatoid Arthritis Osteoarthritis Pain Rheumatoid Arthritis
Risk factors for serious side effects
LodineNorco
    Coming soon.
    • Current liver disease
    • Taking with alcohol
    • Taking other medicines with acetaminophen
    • Age 65 or greater
    • Higher dose
    Detailed Norco (hydrocodone / acetaminophen) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    LodineNorco
    No alcohol related info.
    • Avoid alcohol.
    Food
    LodineNorco
    No food related info.
    • Take it with food to lower the chance of an upset stomach.
    Kidneys and liver
    LodineNorco
    No kidneys and liver related info.
    • The acetaminophen component in Norco (Hydrocodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Norco (Hydrocodone / Acetaminophen) can cause serious harm to your liver. You may develop life-threatening liver problems that need a liver transplant. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Norco (Hydrocodone / Acetaminophen).
    • Don't take more than instructed to prevent liver damage.
    Pain
    LodineNorco
    No pain related info.
    • This is a combination pain medication. It contains both an opioid medicine and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain. Starts working in 30 minutes and pain relief lasts 4 to 6 hours.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    • Combination pain medicine with an opiod component (hydrocodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    Sleep
    LodineNorco
    No sleep related info.
    • Can help you fall asleep easier.
    • Dizziness and drowsiness is common.
    Upsides and benefits
    LodineNorco
    Coming soon
    • Combination pain medicine with an opiod component (hydrocodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relief for moderate to severe pain to improve quality of life.
    • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
    • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    Downsides and risks
    LodineNorco
    Coming soon
    • Dizziness and drowsiness is common.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Norco if you need.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • The non-opioid part of Norco, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    Tips from our pharmacists for people taking the medication
    LodineNorco
    Coming soon
    • This is a combination pain medication. It contains both an opioid medicine and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain. Starts working in 30 minutes and pain relief lasts 4 to 6 hours.
    • Can make you dizzy or drowsy. Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time and at the lowest dose possible, to lower your chance of becoming addicted.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    Learn more
    More about LodineSide effectsReviews & ratingsFDA package insert
    Have you used Lodine (etodolac)?
    Worth itNot sureNot worth it
    More about NorcoSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Norco (hydrocodone / acetaminophen)?
    Worth itNot sureNot worth it